Insertion of miRNA125b-1 into immunoglobulin heavy chain gene locus mediated by V(D)J recombination in precursor B cell acute lymphoblastic leukemia

Abstract We studied the arrangement of the immunoglobulin heavy chain genes by Southern blot analysis of DNA freshly obtained from marrow blast cells of 14 children with T cell acute lymphoblastic leukemia (T-ALL) using probes to the C mu and JH gene segments: At least one of the C mu-gene alleles was rearranged in three cases. In two of these, one C mu gene had the germ-line configuration and one was rearranged, whereas both alleles were rearranged in the third case. In one case, a rearranged heavy chain gene hybridized to the C mu-region probe, but not to the JH probe, indicating that the entire JH region had been deleted. These results demonstrate that immunoglobulin heavy chain gene rearrangements are not restricted to B lineage lymphoproliferative diseases in humans.

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Clonal evolution as judged by immunoglobulin heavy chain gene rearrangements in relapsing precursor-B acute lymphoblastic leukemia

European Journal Of Haematology ◽

10.1111/j.1600-0609.1999.tb01765.x ◽

2009 ◽

Vol 63 (3) ◽

pp. 171-179 ◽

Cited By ~ 23

Author(s):

R. Rosenquist ◽

U. Thunberg ◽

A.-H. Li ◽

E. Forestier ◽

G. Lönnerholm ◽

...

Keyword(s):

Acute Lymphoblastic Leukemia ◽

Heavy Chain ◽

Lymphoblastic Leukemia ◽

Clonal Evolution ◽

Immunoglobulin Heavy Chain ◽

Chain Gene ◽

Gene Rearrangements ◽

Heavy Chain Gene ◽

Immunoglobulin Heavy Chain Gene

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Clinical significance of productive immunoglobulin heavy chain gene rearrangements in childhood acute lymphoblastic leukemia

Leukemia & Lymphoma ◽

10.3109/10428194.2011.582907 ◽

2011 ◽

Vol 52 (9) ◽

pp. 1751-1757 ◽

Cited By ~ 1

Author(s):

Katerina Katsibardi ◽

Maria Braoudaki ◽

Chrissa Papathanasiou ◽

Kalliopi Karamolegou ◽

Fotini Tzortzatou-Stathopoulou

Keyword(s):

Acute Lymphoblastic Leukemia ◽

Clinical Significance ◽

Heavy Chain ◽

Lymphoblastic Leukemia ◽

Immunoglobulin Heavy Chain ◽

Childhood Acute Lymphoblastic Leukemia ◽

Chain Gene ◽

Gene Rearrangements ◽

Heavy Chain Gene ◽

Immunoglobulin Heavy Chain Gene

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Rearrangement of immunoglobulin heavy chain genes in T cell acute lymphoblastic leukemia

Blood ◽

10.1182/blood.v65.3.725.bloodjournal653725 ◽

1985 ◽

Vol 65 (3) ◽

pp. 725-729

Author(s):

GR Kitchingman ◽

U Rovigatti ◽

AM Mauer ◽

S Melvin ◽

SB Murphy ◽

...

Keyword(s):

Acute Lymphoblastic Leukemia ◽

T Cell ◽

Heavy Chain ◽

Germ Line ◽

Lymphoblastic Leukemia ◽

Immunoglobulin Heavy Chain ◽

Chain Gene ◽

Heavy Chain Gene ◽

Cell Acute Lymphoblastic Leukemia ◽

Immunoglobulin Heavy Chain Genes

We studied the arrangement of the immunoglobulin heavy chain genes by Southern blot analysis of DNA freshly obtained from marrow blast cells of 14 children with T cell acute lymphoblastic leukemia (T-ALL) using probes to the C mu and JH gene segments: At least one of the C mu-gene alleles was rearranged in three cases. In two of these, one C mu gene had the germ-line configuration and one was rearranged, whereas both alleles were rearranged in the third case. In one case, a rearranged heavy chain gene hybridized to the C mu-region probe, but not to the JH probe, indicating that the entire JH region had been deleted. These results demonstrate that immunoglobulin heavy chain gene rearrangements are not restricted to B lineage lymphoproliferative diseases in humans.

Download Full-text