Senile dementia of Lewy body type – clinical features and prevalence in neuropathological postmortems

1996 ◽  
pp. 161-170
Author(s):  
L. M. Drach ◽  
S. Wach ◽  
J. Bohl
Keyword(s):  
Clinical Features ◽  
Lewy Body ◽  
Senile Dementia ◽  
Body Type

Dementia with Lewy bodies

1998 ◽  
Vol 4 (6) ◽  
pp. 360-363 ◽  
Author(s):  
E. Jane Byrne
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lewy Body ◽  
Senile Dementia ◽  
Lewy Bodies ◽  
Lewy Body Dementia ◽  
Body Type ◽  
Clinical Criteria ◽  
Dementia Syndrome ◽  
Distinct Disease

Dementia with cortical Lewy bodies (LBD) was first described by Okazakiet alin 1961 and is now recognised as a relatively common cause of the dementia syndrome. The true prevalence of LBD is unknown. In post-mortem studies of patients diagnosed as having dementia in life, the mean frequency of Lewy body dementia is 12.5% (Byrne, 1997). Clinically diagnosed LBD (using operational clinical criteria) is found in 10–23% of patients presenting to, or in the care of, psychogeriatric services (Collertonet al, 1996). What is not yet certain is its nosological status; opinion is divided between regarding it as a variety of Alzheimer's disease (the Lewy body variant), a distinct disease (senile dementia of the Lewy body type) or a spectrum disorder related to both Parkinson's disease and to Alzheimer's disease (Byrne, 1992).

Cholinergic and Dopaminergic Activities in Senile Dementia of Lewy Body Type

1990 ◽  
Vol 4 (2) ◽  
pp. 87-95 ◽  
Author(s):  
Elaine K. Perry ◽  
Elizabeth Marshall ◽  
Robert H. Perry ◽  
Dorothy Irving ◽  
Carthage J. Smith ◽  
...  
Keyword(s):  
Lewy Body ◽  
Senile Dementia ◽  
Body Type

Associations of Psychotic Symptoms in Dementia Sufferers

1995 ◽  
Vol 167 (4) ◽  
pp. 537-540 ◽  
Author(s):  
Clive Ballard ◽  
Carol Bannister ◽  
Candida Graham ◽  
Femi Oyebode ◽  
Gordon Wilcock
Keyword(s):  
Visual Impairment ◽  
Life Events ◽  
Lewy Body ◽  
Senile Dementia ◽  
Psychotic Symptoms ◽  
Symptom Checklist ◽  
Visual Hallucinations ◽  
Body Type ◽  
Sensory Impairments ◽  
Single Category

BackgroundPsychotic symptoms in dementia have been considered as a single category which may have masked important associations. An exploratory analysis was undertaken to look separately at delusions, visual hallucinations and delusional misidentification.MethodPsychotic symptoms were assessed with the Burns' Symptom Checklist in 124 patients with DSM–III–R dementia.ResultsEighty-three (66.9%) patients had psychotic symptoms. Deafness and life events were associated with delusions and visual impairment was associated with visual hallucinations, while senile dementia of Lewy body type and older age were associated with both.ConclusionsDifferences are evident in the associations of delusions and visual hallucinations. Sensory impairments were associated with both symptoms.

Cholinergic and Dopaminergic Activities in Senile Dementia of Lewy Body Type

1990 ◽  
Vol 4 (2) ◽  
pp. 87-95 ◽  
Author(s):  
Elaine K. Perry ◽  
Elizabeth Marshall ◽  
Robert H. Perry ◽  
Dorothy Irving ◽  
Carthage J. Smith ◽  
...  
Keyword(s):  
Lewy Body ◽  
Senile Dementia ◽  
Body Type

Abnormally Phosphorylated Tau Protein in Senile Dementia of Lewy Body Type and Alzheimer Disease

1995 ◽  
Vol 9 (4) ◽  
pp. 218-222 ◽  
Author(s):  
C. Strong ◽  
B. H. Anderton ◽  
R. H. Perry ◽  
E. K. Perry ◽  
P. G. Ince ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Tau Protein ◽  
Lewy Body ◽  
Senile Dementia ◽  
Phosphorylated Tau ◽  
Body Type ◽  
Phosphorylated Tau Protein

A quantitative comparison of plaque types in Alzheimer's disease and senile dementia of the Lewy body type

1996 ◽  
Vol 91 (5) ◽  
pp. 526-529 ◽  
Author(s):  
Jeanette E. McKenzie ◽  
Richard J. Edwards ◽  
Stephen M. Gentleman ◽  
Paul G. Ince ◽  
Robert H. Perry ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lewy Body ◽  
Senile Dementia ◽  
Quantitative Comparison ◽  
Body Type ◽  
Senile Dementia Of The

The Clinical Diagnosis and Misdiagnosis of Senile Dementia of Lewy Body Type (SDLT)

1994 ◽  
Vol 165 (3) ◽  
pp. 324-332 ◽  
Author(s):  
I. G. Mckeith ◽  
A. F. Fairbairn ◽  
R. H. Perry ◽  
P. Thompson
Keyword(s):  
Clinical Diagnosis ◽  
Lewy Body ◽  
Senile Dementia ◽  
The Elderly ◽  
Clinical Syndrome ◽  
Body Type ◽  
External Criterion ◽  
Clinical Criteria ◽  
Diagnostic Categories ◽  
Neuropathological Diagnosis

BackgroundCurrent clinical classifications do not contain specific diagnostic categories for patients with senile dementia of the Lewy body type (SDLT), recently proposed as the second commonest neuropathological cause of dementia in the elderly. This study determines how existing clinical diagnosis systems label SDLT patients and suggests how such patients may be identified.MethodA range of clinical diagnostic criteria for dementia were applied to case notes of autopsy-confirmed SDLT (n = 20), dementia of Alzheimer type (DAT; n = 21) and multi-infarct dementia (MID; n = 9) patients who had received psychogeriatric assessment. The predictive validity of each set of clinical criteria was calculated against the external criterion of neuropathological diagnosis.ResultsMany SDLT patients erroneously met criteria for MID (35% with Hachinski scores ≥ 7) or for DAT (15% by NINCDS ‘probable AD’, 35% by DSM–III–R DAT and 50% by NINCDS ‘possible AD’). Up to 85% of SDLT cases could be correctly identified using recently published specific criteria.ConclusionsDLT usually has a discernible clinical syndrome and existing clinical classifications may need revision to diagnose correctly such patients.

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