Friendships and romantic relationships are characterized by enduring concern for each other’s welfare. It is perhaps not surprising, then, that advice, a form of social support, is common, expected, and even desired in intimate relationships. While much of the research on advice samples from friendships and romantic relationships, the influence of the specific relational context is often overlooked. This chapter addresses this limitation with a synthesis of theory and research from relationship science. Specifically, it explores the potential contributions of interdependence theory (Kelley & Thibaut, 1978), relationship turbulence theory (Solomon, Knobloch, Theiss, & McLaren, 2016), attachment theory (Bowlby, 1969), and confirmation theory (Dailey, 2006) to understand how relationship cognitions affect advice outcomes. The chapter also discusses the intersections between these theories as applied to advice and shows how these theories can guide best practices of advising in close relationships.