Advancing articular cartilage repair through tissue engineering: from materials and cells to clinical translation

2015 ◽  
pp. 488-513
Author(s):  
Megan J. Farrell ◽  
Robert L. Mauck
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Cartilage Repair ◽  
Clinical Translation ◽  
Articular Cartilage Repair

Functional Tissue Engineering in Articular Cartilage Repair: Is There a Role for Electromagnetic Biophysical Stimulation?

2013 ◽  
Vol 19 (4) ◽  
pp. 353-367 ◽  
Author(s):  
Milena Fini ◽  
Stefania Pagani ◽  
Gianluca Giavaresi ◽  
Monica De Mattei ◽  
Alessia Ongaro ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Cartilage Repair ◽  
Articular Cartilage Repair ◽  
Functional Tissue Engineering ◽  
Functional Tissue

Cell-derived decellularized extracellular matrix scaffolds for articular cartilage repair

2020 ◽  
pp. 039139882095386
Author(s):  
Wenrun Zhu ◽  
Lu Cao ◽  
Chunfeng Song ◽  
Zhiying Pang ◽  
Haochen Jiang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Articular Cartilage ◽  
Cartilage Repair ◽  
Cell Attachment ◽  
Tissue Growth ◽  
Bioactive Molecules ◽  
Cartilage Tissue ◽  
Articular Cartilage Repair ◽  
Decellularized Extracellular Matrix

Articular cartilage repair remains a great clinical challenge. Tissue engineering approaches based on decellularized extracellular matrix (dECM) scaffolds show promise for facilitating articular cartilage repair. Traditional regenerative approaches currently used in clinical practice, such as microfracture, mosaicplasty, and autologous chondrocyte implantation, can improve cartilage repair and show therapeutic effect to some degree; however, the long-term curative effect is suboptimal. As dECM prepared by proper decellularization procedures is a biodegradable material, which provides space for regeneration tissue growth, possesses low immunogenicity, and retains most of its bioactive molecules that maintain tissue homeostasis and facilitate tissue repair, dECM scaffolds may provide a biomimetic microenvironment promoting cell attachment, proliferation, and chondrogenic differentiation. Currently, cell-derived dECM scaffolds have become a research hotspot in the field of cartilage tissue engineering, as ECM derived from cells cultured in vitro has many advantages compared with native cartilage ECM. This review describes cell types used to secrete ECM, methods of inducing cells to secrete cartilage-like ECM and decellularization methods to prepare cell-derived dECM. The potential mechanism of dECM scaffolds on cartilage repair, methods for improving the mechanical strength of cell-derived dECM scaffolds, and future perspectives on cell-derived dECM scaffolds are also discussed in this review.

Articular cartilage repair using allogeneic perichondrocyteseeded biodegradable porous polylactic acid (PLA): A tissue-engineering study

1995 ◽  
Vol 29 (9) ◽  
pp. 1147-1154 ◽  
Author(s):  
Constance R. Chu ◽  
Richard D. Coutts ◽  
Makoto Yoshioka ◽  
Frederick L. Harwood ◽  
Anna Z. Monosov ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Polylactic Acid ◽  
Cartilage Repair ◽  
Articular Cartilage Repair ◽  
Engineering Study

Donor Cell Fate in Tissue Engineering for Articular Cartilage Repair

2001 ◽  
Vol 389 ◽  
pp. 228-237 ◽  
Author(s):  
Roger V. Ostrander ◽  
Randal S. Goomer ◽  
William L. Tontz ◽  
Monti Khatod ◽  
Frederick L. Harwood ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Cell Fate ◽  
Cartilage Repair ◽  
Donor Cell ◽  
Articular Cartilage Repair

scholarly journals Hidrogeles de polimerización in situ para la regeneración de cartílago articular. [In-situ-forming hydrogels for articular cartilage repair]

2019 ◽  
Vol 84 (3) ◽  
pp. 296-308
Author(s):  
Francisco Rodríguez-Fontán ◽  
Cecilia Pascual-Garrido
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Cartilage Repair ◽  
Joint Surface ◽  
Articular Cartilage Repair ◽  
Tissue Scaffold ◽  
Chondral Lesions ◽  
Biomaterial Scaffold ◽  
Patient Reported

Una significativa cantidad de adultos jóvenes activos sufre lesiones condrales focales. Estas lesiones, si no se tratan, pueden progresar hacia la artrosis, que es una de las principales enfermedades musculoesqueléticas debilitantes y de gran carga económica que afectan a toda sociedad. Pese a los tratamientos quirúrgicos disponibles para la reparación de defectos condrales focales sintomáticos que mejoran la calidad de vida a mediano plazo, hay un mayor riesgo de progresión hacia la artrosis prematura. Los tratamientos biológicos (células madre, bioingeniería tisular) han avanzado a grandes pasos en los últimos años. La bioingeniería es un área que ha progresado en la regeneración de cartílago articular y que potencialmente podría progresar en el terreno de tratamientos articulares, promoviendo la regeneración y evitando la degeneración. Las células madre y los hidrogeles pueden proveer un tejido símil biológico de comportamiento dinámico-funcional equivalente que induce la regeneración tisular al ser degradado y reemplazado gradualmente. El abordaje consiste en colocar un hidrogel precursor o un biomaterial tridimensional impreso dentro del defecto condral por ocupar para inducir la regeneración. Esta revisión se focaliza en el uso actual y futuro de hidrogeles y bioimpresión tridimensional para la regeneración de cartílago articular en el tratamiento de lesiones condrales focales y proporciona datos preliminares de dos estudios piloto en animales. AbstractA significant number of young active adults are affected by focal chondral lesions. These lesions, if left untreated, will progress to osteoarthritis (OA). OA is one of the main debilitating musculoskeletal diseases and leads to a high economic and social burden. Despite surgical cartilage repair for focal chondral lesions, which improve patient-reported outcomes at short- and mid-term, there is a risk of early OA progression. Biological treatments (i.e., stem-cell therapy, bioengineering) have made great progress in the last years. Tissue engineering is an evolving field for articular cartilage repair which could potentially be used for the treatment of focal chondral lesions, promoting regeneration and preventing joint surface degeneration. Stem cells and hydrogels may provide a functional, dynamic and biologically equivalent tissue that promotes tissue regeneration while being gradually degraded and replaced. The standard approach to tissue engineering consists in delivering cells within a hydrogel or a three-dimensional printed biomaterial scaffold into the chondral lesion to induce regeneration. This review focuses on the current and future use of hydrogels and tissue scaffold bioprinting for the treatment of focal chondral lesions, and provides preliminary data from two pilot animal studies.

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