Lyme Borreliosis (Lyme Disease)

1993 ◽  
pp. 852-855
Author(s):  
Robert D. Leff
Keyword(s):  
Lyme Disease ◽  
Lyme Borreliosis

scholarly journals Diagnostic parameters of modified two-tier testing in European patients with early Lyme disease

2020 ◽  
Vol 39 (11) ◽  
pp. 2143-2152
Author(s):  
ME Baarsma ◽  
JFP Schellekens ◽  
BC Meijer ◽  
AH Brandenburg ◽  
T. Souilljee ◽  
...  
Keyword(s):  
General Practice ◽  
Lyme Disease ◽  
General Population ◽  
Lyme Borreliosis ◽  
Erythema Migrans ◽  
Diagnostic Parameters ◽  
Second Tier ◽  
Population Controls ◽  
Higher Sensitivity ◽  
Better Than

Abstract Modified two-tier testing (MTTT) for Lyme borreliosis (i.e. confirmation with an EIA instead of an immunoblot) has been shown to have improved sensitivity compared with standard two-tier testing (STTT) in samples from American patients, without losing specificity. The current study assesses the sensitivity and specificity of various algorithms of MTTT in European patients with erythema migrans (EM) as a model disease for early Lyme borreliosis, and in appropriate controls. Four different immunoassays were used in the first tier, followed by either an immunoblot or the C6-EIA, or were used as standalone single-tier test. These tests were performed on consecutively collected sera of 228 Dutch patients with physician-diagnosed EM in the setting of general practice, 231 controls from the general population, and 50 controls with potentially cross-reactive antibodies. All the variants of MTTT that were studied had significantly higher sensitivity compared with their equivalent STTT, while retaining comparable specificity. Within the MTTT algorithms, classifying equivocal results as positive yielded better diagnostic parameters than classifying equivocal results as negative. The best diagnostic parameters were found using the Enzygnost-2 assay in the first tier, followed by a C6-ELISA in the second tier (sensitivity 77.6%, 95% CI 71.7–82.9; specificity 96.1%, 95% CI 92.7–98.2). This algorithm performed significantly better than the equivalent STTT algorithm in terms of sensitivity (p < 0.001), while maintaining comparable specificity (population controls p = 0.617). Our results show that MTTT can be a useful tool for the serodiagnosis of European patients with early Lyme borreliosis.

scholarly journals Lyme borreliosis in the Netherlands: strong increase in GP consultations and hospital admissions in past 10 years

2006 ◽  
Vol 11 (25) ◽  
Author(s):  
A Hofhuis ◽  
J W van der Giessen ◽  
F Borgsteede ◽  
P R Wielinga ◽  
D W Notermans ◽  
...  
Keyword(s):  
Lyme Disease ◽  
The Netherlands ◽  
Lyme Borreliosis ◽  
Hospital Admissions ◽  
Strong Increase

Lyme borreliosis (Lyme disease) is not notifiable in the Netherlands

scholarly journals Lyme borreliosis: Europe-wide coordinated surveillance and action needed?

2006 ◽  
Vol 11 (25) ◽  
Author(s):  
R. Smith ◽  
J Takkinen ◽  
Collective Editorial team
Keyword(s):  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Lyme Borreliosis

Lyme borreliosis (Lyme disease) is an infection caused by the spirochete bacteria Borrelia burgdorferi

scholarly journals Lyme Borreliosis as Cause of Myocarditis: A Case Report and a Review of the Literature

2021 ◽  
Vol 07 (12) ◽  
Author(s):  
Yousra Serroukh ◽  
Keyword(s):  
Case Report ◽  
Lyme Disease ◽  
Lyme Borreliosis ◽  
Clinical Manifestations ◽  
Left Ventricular ◽  
Review Of The Literature ◽  
Conduction Disorders ◽  
Lyme Carditis ◽  
The Subject ◽  
Cardiac Manifestation

lyme borreliosis (LB) is the most common tick-born disease in the Northern Hemisphere. During early disseminated Lyme disease, cardiac manifestation can occur. including acute conduction disorders, atrioventricular block, acute myopericarditis or left ventricular dysfunction and rarely cardiomegaly or fatal pericarditis. We report a case of a patient with isolated Lyme myocarditis manifested by acute heart failure with atrial fibrillation and review of the literature on the subject. The interested of this case report is to show the need to acquire the reflex to think about a lyme carditis when patients in endemic areas come to attention with cardiovasculair symtoms, even in the absence of others concurerenr clinical manifestations of early lyme disease.

scholarly journals AWARENESS OF LYME BORRELIOSIS OF THE PATIENTS OF TERNOPIL REGIONAL TB DISPENSARY

2017 ◽  
Author(s):  
L. P. Melnyk ◽  
L. A. Hryshchuk ◽  
M. Koziol–Montewka ◽  
P. S. Tabas ◽  
R. O. Klos
Keyword(s):  
Nervous System ◽  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Lyme Borreliosis ◽  
Preventive Measures ◽  
Epidemiological Data ◽  
Sufficient Information ◽  
Tick Bites ◽  
The World ◽  
History Of

Background. Lyme disease has many clinical features similar tothose in sarcoidosis and tuberculosis. Epidemiological data in the world, in particular in Ukraine, proves the increase in Lyme borreliosis incidence. Ternopil region is endemic with Lyme borreliosis.Objective. The research was aimed to investigate the prevalence of infection with Borrelia burgdorferi and epidemiology features of borreliosis among the patients of Ternopil Regional TB Dispensary.Methods. In total, 29 patients were admitted to Departments of Differential Diagnostic, TB Therapy and TB Surgery of Ternopil Regional TB Dispensary in October 2016-January 2017. All the surveyed answered the questions of an integrated international questionnaire, where they noted the area and a number of tick bites, described the removal method, noted the survey for borreliosis pathogen and complaints after tick bites.Results. It was established that 5 respondents had a history of tick bites episodes, but only in one case the patient was examined of borreliosis. Tick bites were noticed in 3 patients with sarcoidosis and 1 with tuberculosis (TB) and exudative pleurisy, respectively.Conclusions. The absence of appeals for medical care, lack of sufficient information on Lyme borreliosis and disuse of preventive measures for tick bites by the interviewed patients of Ternopil regional TB dispensary departments proves the need of improvement of health education on Lyme borreliosis (LB) among this category of population. 24 (82.7%) of 29 respondents did not remember the tick bite. The symptoms of (LB) are similar to those in sarcoidosis and tuberculosis (pleural lesions, heart, joints, nervous system, skin), and the presence of tick bites gives the reasons to examine these patients of Borrelia burgdorferi senso lato.

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