scholarly journals Lyme borreliosis: Europe-wide coordinated surveillance and action needed?

2006 ◽  
Vol 11 (25) ◽  
Author(s):  
R. Smith ◽  
J Takkinen ◽  
Collective Editorial team

Lyme borreliosis (Lyme disease) is an infection caused by the spirochete bacteria Borrelia burgdorferi

Author(s):  
L. P. Melnyk ◽  
L. A. Hryshchuk ◽  
M. Koziol–Montewka ◽  
P. S. Tabas ◽  
R. O. Klos

Background. Lyme disease has many clinical features similar tothose in sarcoidosis and tuberculosis. Epidemiological data in the world, in particular in Ukraine, proves the increase in Lyme borreliosis incidence. Ternopil region is endemic with Lyme borreliosis.Objective. The research was aimed to investigate the prevalence of infection with Borrelia burgdorferi and epidemiology features of borreliosis among the patients of Ternopil Regional TB Dispensary.Methods. In total, 29 patients were admitted to Departments of Differential Diagnostic, TB Therapy and TB Surgery of Ternopil Regional TB Dispensary in October 2016-January 2017. All the surveyed answered the questions of an integrated international questionnaire, where they noted the area and a number of tick bites, described the removal method, noted the survey for borreliosis pathogen and complaints after tick bites.Results. It was established that 5 respondents had a history of tick bites episodes, but only in one case the patient was examined of borreliosis. Tick bites were noticed in 3 patients with sarcoidosis and 1 with tuberculosis (TB) and exudative pleurisy, respectively.Conclusions. The absence of appeals for medical care, lack of sufficient information on Lyme borreliosis and disuse of preventive measures for tick bites by the interviewed patients of Ternopil regional TB dispensary departments proves the need of improvement of health education on Lyme borreliosis (LB) among this category of population. 24 (82.7%) of 29 respondents did not remember the tick bite. The symptoms of (LB) are similar to those in sarcoidosis and tuberculosis (pleural lesions, heart, joints, nervous system, skin), and the presence of tick bites gives the reasons to examine these patients of Borrelia burgdorferi senso lato.


1998 ◽  
Vol 66 (3) ◽  
pp. 1248-1251 ◽  
Author(s):  
Klaus Kurtenbach ◽  
Henna-Sisko Sewell ◽  
Nick H. Ogden ◽  
Sarah E. Randolph ◽  
Patricia A. Nuttall

ABSTRACT The sensitivity of Borrelia burgdorferi sensu lato to animal sera was analyzed. Complement-mediated borreliacidal effects were observed with particular combinations of host serum andBorrelia genospecies. The species-specific pattern of viability and/or lysis is highly consistent with the pattern of reservoir competence of hosts for B. burgdorferi sensu lato, suggesting a key role of complement in the global ecology of Lyme borreliosis.


2014 ◽  
Vol 63 (5) ◽  
pp. 674-684 ◽  
Author(s):  
Kerry L. Clark ◽  
Brian F. Leydet ◽  
Clifford Threlkeld

The present study investigated the cause of illness in human patients primarily in the southern USA with suspected Lyme disease based on erythema migrans-like skin lesions and/or symptoms consistent with early localized or late disseminated Lyme borreliosis. The study also included some patients from other states throughout the USA. Several PCR assays specific for either members of the genus Borrelia or only for Lyme group Borrelia spp. (Borrelia burgdorferi sensu lato), and DNA sequence analysis, were used to identify Borrelia spp. DNA in blood and skin biopsy samples from human patients. B. burgdorferi sensu lato DNA was found in both blood and skin biopsy samples from patients residing in the southern states and elsewhere in the USA, but no evidence of DNA from other Borrelia spp. was detected. Based on phylogenetic analysis of partial flagellin (flaB) gene sequences, strains that clustered separately with B. burgdorferi sensu stricto, Borrelia americana or Borrelia andersonii were associated with Lyme disease-like signs and symptoms in patients from the southern states, as well as from some other areas of the country. Strains most similar to B. burgdorferi sensu stricto and B. americana were found most commonly and appeared to be widely distributed among patients residing throughout the USA. The study findings suggest that human cases of Lyme disease in the southern USA may be more common than previously recognized and may also be caused by more than one species of B. burgdorferi sensu lato. This study provides further evidence that B. burgdorferi sensu stricto is not the only species associated with signs and/or symptoms consistent with Lyme borreliosis in the USA.


2007 ◽  
Vol 23 (5-6-2) ◽  
pp. 215-221
Author(s):  
S. Savic-Jevdjenic ◽  
Z. Grgic ◽  
B. Vidic ◽  
A. Petrovic

Lyme disease, or Lyme borreliosis can occur in domestic animals and in people, with no characteristic symptoms. That is why Lyme disease is often diagnosed and treated as some other disease. Clinical symptoms of this disease are not specific and they can look like a number of different diseases, which is why the disease is called - the great imitator. The reservoirs of the disease are ticks Ixodes ricinus. During the research from 2005 to 2007 it was established that the prevalence with Lyme borreliosis exists within the tick population. The objective of this paper is a survey of the presence of Lyme disease in different populations of different animal species (horses, cattle, sheep and dogs) in the region where the infection of ticks with Borrelia burgdorferi was established in the percentage of 25-28%. The methods used were the ones for the determination of Borrelia burgdorferi in ticks, with a dark field microscopy, and also the presence of antibodies against Borrelia burgdorferi was determinate with a complement fixation reaction, in the blood sera of horses, sheep, cattle and dogs. As the result it was found that the cause of Lyme disease, Borrelia burgdorferi is constantly present within the tick population. In examined horses and cattle the presence of antibodies against B. burgdorferi was not found, while in sheep and dogs, the presence of antibodies was found. Any seropositive animal, and also an infected tick, represents a danger for the human population and also for other animals, which are in the surrounding. Lyme disease is usually not mortal, but it can create a lot of problems leading to the decrease of production in domestic animals or an illness with clinical symptoms in humans, horses and dogs.


2021 ◽  
Author(s):  
Matthew K. Muramatsu ◽  
Jianli Zhou ◽  
Bryna L. Fitzgerald ◽  
Ranjit K. Deka ◽  
John T. Belisle ◽  
...  

Riboflavin is an essential micronutrient, but its transport and utilization has remained largely understudied among pathogenic spirochetes. Here we show that Borrelia burgdorferi , the zoonotic spirochete that causes Lyme disease, is able to import riboflavin via products of its rfuABCD -like operon as well as synthesize flavin mononucleotide and flavin adenine dinucleotide despite lacking canonical genes for their synthesis. Additionally, a mutant deficient in the rfuABCD -like operon is resistant to the antimicrobial effect of roseoflavin, a natural riboflavin analog, and is attenuated in a murine model of Lyme borreliosis. Our combined results indicate that not only are riboflavin and the maintenance of flavin pools essential for B. burgdorferi growth, but that flavin utilization and its downstream products (e.g., flavoproteins) may play a more prominent role in B. burgdorferi pathogenesis than previously appreciated.


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