scholarly journals dl-Methionine supplementation in a low-fishmeal diet affects the TOR/S6K pathway by stimulating ASCT2 amino acid transporter and insulin-like growth factor-I in the dorsal muscle of juvenile cobia (Rachycentron canadum) – CORRIGENDUM

2021 ◽  
pp. 1-1
Author(s):  
Yuanfa He ◽  
Shuyan Chi ◽  
Beiping Tan ◽  
Xiaohui Dong ◽  
Qihui Yang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Growth Factor ◽  
Amino Acid Transporter ◽  
Insulin Like Growth Factor ◽  
Rachycentron Canadum ◽  
Dorsal Muscle ◽  
Factor I ◽  
Methionine Supplementation ◽  
Growth Factor I ◽  
Acid Transporter

scholarly journals dl-Methionine supplementation in a low-fishmeal diet affects the TOR/S6K pathway by stimulating ASCT2 amino acid transporter and insulin-like growth factor-I in the dorsal muscle of juvenile cobia (Rachycentron canadum)

2019 ◽  
Vol 122 (07) ◽  
pp. 734-744 ◽  
Author(s):  
Yuanfa He ◽  
Shuyan Chi ◽  
Beiping Tan ◽  
Xiaohui Dong ◽  
Qihui Yang ◽  
...  
Keyword(s):  
Weight Gain ◽  
Amino Acid ◽  
Growth Factor ◽  
Mrna Levels ◽  
Insulin Like Growth Factor ◽  
Rachycentron Canadum ◽  
Dorsal Muscle ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I

AbstractAn 8-week feeding experiment was conducted to investigate the effects of dl-methionine (Met) supplementation in a low-fishmeal diet on growth, key gene expressions of amino acid transporters and target of rapamycin (TOR) pathway in juvenile cobia, Rachycentron canadum. Seven isonitrogenous and isolipidic diets were formulated, containing 0·72, 0·90, 1·00, 1·24, 1·41, 1·63 and 1·86 % Met. Weight gain and specific growth rates increased gradually with Met levels of up to 1·24 % and then decreased gradually. In dorsal muscle, mRNA levels of ASCT2 in the 1·00 % Met group were significantly up-regulated compared with 0·72, 1·63, and 1·86 %. The insulin-like growth factor-I (IGF-I) mRNA levels in the dorsal muscle of fish fed 1·00 and 1·24 % Met were higher than those in fish fed other Met levels. In addition, fish fed 1·24 % Met showed the highest mRNA levels of TOR and phosphorylation of TOR on Ser2448. The phosphorylation of ribosomal p70-S6 kinase (S6K) on Ser371 in the dorsal muscle of fish fed 1·86 % Met was higher than those in the 0·72 % group. In conclusion, straight broken-line analysis of weight gain rate against dietary Met level indicates that the optimal Met requirement for juvenile cobia is 1·24 % (of DM, or 2·71 % dietary protein). Met supplementation in a low-fishmeal diet increased cobia growth via a mechanism that can partly be attributed to Met’s ability to affect the TOR/S6K signalling pathway by enhancing ASCT2 and IGF-I transcription in cobia dorsal muscle.

Effects of insulin, insulin-like growth factor-I (IGF-I) and progesterone on glucose and amino acid uptake in Xenopus laevis oocytes

1991 ◽  
Vol 75 (2) ◽  
pp. 133-139 ◽  
Author(s):  
Pierre Hainaut ◽  
Aline Kowalski ◽  
Yannick Le Marchand-Brustel ◽  
Sophie Giorgetti ◽  
Nadine Gautier ◽  
...  
Keyword(s):  
Amino Acid ◽  
Growth Factor ◽  
Xenopus Laevis ◽  
Amino Acid Uptake ◽  
Xenopus Laevis Oocytes ◽  
Acid Uptake ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I

Effects of insulin-like growth factor-I on glucose metabolism and hepatic amino acid-N conversion in patients with liver cirrhosis

2001 ◽  
Vol 34 ◽  
pp. 13
Author(s):  
T. Grofte ◽  
J. Greisen ◽  
N.Kristian Aagaard ◽  
O. Schmidt ◽  
J.Sandahl Christiansen ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Amino Acid ◽  
Growth Factor ◽  
Glucose Metabolism ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

Direct infusion of a variant of insulin-like growth factor-I into the skin of sheep and effects on local blood flow, amino acid utilization and cell replication

1993 ◽  
Vol 139 (3) ◽  
pp. 463-472 ◽  
Author(s):  
P. M. Harris ◽  
B. W. McBride ◽  
M. P. Gurnsey ◽  
B. R. Sinclair ◽  
J. Lee
Keyword(s):  
Blood Flow ◽  
Amino Acid ◽  
Growth Factor ◽  
Amino Acid Uptake ◽  
Acid Uptake ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Amino Acid Utilization ◽  
Igf I ◽  
Growth Factor I

ABSTRACT In vivo effects of local infusion of a variant of insulin-like growth factor-I (IGF-I), long-R3-IGF-I, into the skin were investigated using six conscious sheep with food available ad libitum. An artery and vein on the abdominal flank of each animal, as well as the saphenous artery, were catheterized so that infusion of isotopically labelled amino acids, with or without IGF-I, could be used to determine amino acid uptake by arteriovenous difference in combination with blood flow determined by dye dilution. Measurements were made on each animal prior to IGF-I infusion, at hourly intervals for the 4 h of IGF-I infusion into the skin artery, then 2 and 4 h after IGF-I infusion ceased. Numbers of cells replicating in the bulbs of wool follicles in the IGF-I-infused area and in the skin on the contralateral side of each animal were measured after labelling with 5-bromo-2′-deoxyuridine. IGF-I caused a significant increase in the skin blood flow (P<0·05), utilization of oxygen (P<0·05), uptake of cysteine (P<0·05) and phenylalanine (P<0·001), and the rate of utilization of cysteine (P<0·05) for protein synthesis. IGF-I increased amino acid uptake regardless of whether the skin was in negative or positive amino acid balance prior to infusion. During the recovery period amino acid utilization by skin returned towards preinfusion levels. No effects of IGF-I were found on replicating cell numbers in the bulbs of wool follicles. Journal of Endocrinology (1993) 139, 463–472

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