Intracellular growth of some viruses of the pox group. An electron microscopic study of infected chick chorionic cells
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Sections of chorio-allantoic membranes fixed at intervals after infection with large doses of vaccinia virus showed almost homogeneous areas appearing in the cytoplasm after 4 hr.; these areas contained immature forms of virus which had a thin surface membrane and an eccentric ‘nucleoid’, and were surrounded by mitochondria. Mature forms of virus, having a larger central nucleus-like structure and a thicker cortex, were first found in areas of virus growth 10 hr. after inoculation. Similar immature and mature forms were found in cells infected with fowl-pox, myxomatosis and ectromelia viruses. It is concluded that the immature forms are of low infectivity or not infective.
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2004 ◽
Vol 64
(2)
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pp. 171-180
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1999 ◽
Vol 269
(3)
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pp. 183-185
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1974 ◽
Vol 32
◽
pp. 244-245