The Growth of Herpesvirus mulatto in Human Fibroblast

1974 ◽  
Vol 32 ◽  
pp. 244-245
Author(s):  
Glennelle Washington ◽  
Philip P. McGrath ◽  
Peter R. Graze ◽  
Ivor Royston
Keyword(s):  
Rhesus Monkey ◽  
Microscopic Study ◽  
Electron Microscopic Study ◽  
Peripheral Blood ◽  
Human Fibroblast ◽  
Rhesus Monkeys ◽  
Human Fibroblasts ◽  
Electron Microscopic ◽  
Specific Antisera ◽  
Peripheral Blood Leucocytes

Herpes-like viruses were isolated from rhesus monkey peripheral blood leucocytes when co-cultivated with WI-38 cells. The virus was originally designated rhesus leucocyte-associated herpesvirus (LAHV) and subsequently called Herpesvirus mulatta (HVM). The original isolations were from juvenile rhesus monkeys shown to be free of antibody to rhesus cytomegalic virus. The virus could only be propagated in human or simian fibroblasts. Use of specific antisera developed from HVM showed no relationship between this virus and other herpesviruses. An electron microscopic study was undertaken to determine the morphology of Herpesvirus mulatta (HVM) in infected human fibroblasts.

Degeneration of Long-Term Fetal Neostriatal Allografts in the Rhesus Monkey: An Electron Microscopic Study

1993 ◽  
Vol 123 (2) ◽  
pp. 174-180 ◽  
Author(s):  
Gregory A. Helm ◽  
Patricia E. Palmer ◽  
Nathan E. Simmons ◽  
Charles G. DiPierro ◽  
James P. Bennett
Keyword(s):  
Rhesus Monkey ◽  
Microscopic Study ◽  
Electron Microscopic Study ◽  
Electron Microscopic

scholarly journals Splenic Erythroclasia: An Electron Microscopic Study of Hemoglobin H Disease

Blood ◽  
1968 ◽  
Vol 31 (6) ◽  
pp. 778-790 ◽  
Author(s):  
EMMA WENNBERG ◽  
LEON WEISS
Keyword(s):  
Microscopic Study ◽  
Electron Microscopic Study ◽  
Peripheral Blood ◽  
Major Portion ◽  
Electron Microscopic ◽  
Hemoglobin H Disease

Abstract This is an electron microscopic study of the spleen in a case of hemoglobin H disease. The patient showed evidence in the peripheral blood of marked erythrocyte fragmentation. The spleen acted upon the abnormal erythrocytes in two major ways: 1. The erythrocytes entered the sinus lumen simultaneously via two intercellular slits on opposite sides of a lining cell and then split into two sphered fragments (which lay free in the sinus lumen) and the long, thin connecting fragment (which was retained in the cordal compartment and phagocytized). 2. Small, dense, spherical portions of erythrocytes were retained in the cord while the major portion of the cell was released into the sinus lumen. This is suggestive of pitting of rigid intracellular precipitates. The erythrocytes emerged from their passage through the cords and maintained bizarre forms in the sinus lumen. It is possible that the contents of these cells may be partially gelated to account for this.11 This gelation is thought to largely underlie their behavior in their circulation through the spleen. Evidence of increased erythrocytic breakdown was found in the numerous large macrophages present in the cords.

Sign in / Sign up

Export Citation Format

Share Document