Late sino-nasal metastasis from follicular thyroid carcinoma

1994 ◽  
Vol 108 (11) ◽  
pp. 1010-1011 ◽  
Author(s):  
V. L. Cumberworth ◽  
A. Ohri ◽  
G. Morrissey ◽  
R. Stirling
Keyword(s):  
Thyroid Carcinoma ◽  
Nasal Cavity ◽  
Rare Case ◽  
Follicular Thyroid Carcinoma ◽  
Follicular Carcinoma ◽  
Diagnosis And Treatment ◽  
Primary Malignancy

AbstractWe report a rare case of metastasis of a follicular carcinoma of the thyroid to the sino-nasal cavity 12 years after diagnosis and treatment of the primary malignancy and review the literature of previously reported cases.

scholarly journals Choroidal Metastasis from Follicular Thyroid Carcinoma: A Rare Case Report

2018 ◽  
Vol 20 (2) ◽  
pp. 155
Author(s):  
Md Sunny Anam Chowdhury ◽  
Md Abdul Awal
Keyword(s):  
Case Report ◽  
Thyroid Carcinoma ◽  
Lymph Nodes ◽  
Distant Metastasis ◽  
Rare Case ◽  
Follicular Thyroid Carcinoma ◽  
Follicular Carcinoma ◽  
Choroidal Metastasis ◽  
Rare Case Report

<p>Follicular thyroid carcinoma is the second most common thyroid carcinoma and causes distant metastasis more frequently than any other types. Choroidal metastasis from follicular thyroid carcinoma is extremely rare. Only a few cases have been reported since 1979. We present the case of a 60 years old woman developing choroidal metastasis with associated local (lymph nodes) and distant (lungs) metastasis after nine years of diagnosis as primary follicular carcinoma.</p><p>Bangladesh J. Nuclear Med. 20(2): 155-158, July 2017</p>

scholarly journals Overt Skeletal Metastases in a Patient of Occult (Microscopic) Follicular Thyroid Carcinoma: a Rare Case

2017 ◽  
Vol 9 (1) ◽  
pp. 68-70
Author(s):  
Chandan Kumar Jha ◽  
Vinita Agrawal ◽  
Anjali Mishra ◽  
P. K. Pradhan
Keyword(s):  
Thyroid Carcinoma ◽  
Rare Case ◽  
Follicular Thyroid Carcinoma ◽  
Skeletal Metastases

Follicular thyroid carcinoma presenting as skull metastasis: A rare case report and literature review

2017 ◽  
Vol 1 (2) ◽  
pp. 43
Author(s):  
Mouna Rkami ◽  
Intidhar El Bez ◽  
Bechir Letaief ◽  
MohamedFaouzi Ben Slimene ◽  
DorraBen Sellem
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Thyroid Carcinoma ◽  
Rare Case ◽  
Follicular Thyroid Carcinoma ◽  
Skull Metastasis ◽  
Rare Case Report

scholarly journals Hyperfunctioning Solid/Trabecular Follicular Carcinoma of the Thyroid Gland

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Luca Giovanella ◽  
Fabrizio Fasolini ◽  
Sergio Suriano ◽  
Luca Mazzucchelli
Keyword(s):  
Thyroid Carcinoma ◽  
Follicular Thyroid Carcinoma ◽  
Histopathological Examination ◽  
Thyroid Tissue ◽  
Follicular Carcinoma ◽  
First Case ◽  
Right Lobe ◽  
Rare Malignancy ◽  
The Right ◽  
Trabecular Carcinoma

A 68-year-old woman with solid/trabecular follicular thyroid carcinoma inside of an autonomously functioning thyroid nodule is described in this paper. The patient was referred to our clinic for swelling of the neck and an increased pulse rate. Ultrasonography showed a slightly hypoechoic nodule in the right lobe of the thyroid. Despite suppressed TSH levels, the -pertechnetate scan showed a hot area corresponding to the nodule with a suppressed uptake in the remaining thyroid tissue. Histopathological examination of the nodule revealed a solid/trabecular follicular thyroid carcinoma. To the best of our knowledge, this is the first case of hyperfunctioning follicular solid/trabecular carcinoma reported in the literature. Even if a hyperfunctioning thyroid carcinoma is an extremely rare malignancy, careful management is recommended so that a malignancy will not be overlooked in the hot thyroid nodules.

A rare case of follicular thyroid carcinoma in ovarian struma

The Surgeon ◽  
2008 ◽  
Vol 6 (5) ◽  
pp. 313-315 ◽  
Author(s):  
P. Prasad ◽  
D. Nunns ◽  
C.S. Ubhi ◽  
Z. Chaudry ◽  
I. Soomro
Keyword(s):  
Thyroid Carcinoma ◽  
Rare Case ◽  
Follicular Thyroid Carcinoma

A Rare Case of Follicular Thyroid Carcinoma in a Patient With Thyrotropin-Secreting Pituitary Adenoma

2009 ◽  
Vol 337 (6) ◽  
pp. 462-465 ◽  
Author(s):  
Maurizio Poggi ◽  
Salvatore Monti ◽  
Chiara Pascucci ◽  
Vincenzo Toscano
Keyword(s):  
Pituitary Adenoma ◽  
Thyroid Carcinoma ◽  
Rare Case ◽  
Follicular Thyroid Carcinoma

scholarly journals Follicular thyroid carcinoma with NRAS Q61K and GNAS R201H mutations that had a good 131I treatment response

2016 ◽  
Vol 2016 ◽  
Author(s):  
Jin-Ying Lu ◽  
Po-Ju Hung ◽  
Pei-Lung Chen ◽  
Ruoh-Fang Yen ◽  
Kuan-Ting Kuo ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Treatment Response ◽  
Radioactive Iodine ◽  
Follicular Thyroid Carcinoma ◽  
Follicular Carcinoma ◽  
List Type ◽  
131I Treatment ◽  
Autonomously Functioning Thyroid Nodules ◽  
Iodine Treatment ◽  
Gs Alpha

Summary We report a case of follicular thyroid carcinoma with concomitant NRAS p.Q61K and GNAS p.R201H mutations, which manifested as a 13.5 cm thyroid mass with lung, humerus and T9 spine metastases, and exhibited good response to radioactive iodine treatment. Learning points GNAS p.R201H somatic mutation is an activating or gain-of-function mutation resulting in constitutively activated Gs-alpha protein and downstream cAMP cascade, independent of TSH signaling, causing autonomously functioning thyroid nodules. NRAS p.Q61K mutations with GNAS p.R201H mutations are known for a good radioactive iodine treatment response. Further exploration of the GNAS-activating pathway may provide therapeutic insights into the treatment of metastatic follicular carcinoma.

scholarly journals Are prognostic scoring systems of value in patients with follicular thyroid carcinoma?

2013 ◽  
Vol 169 (6) ◽  
pp. 821-827 ◽  
Author(s):  
A Ríos ◽  
J M Rodríguez ◽  
B Ferri ◽  
E Matínez-Barba ◽  
B Febrero ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Follicular Thyroid Carcinoma ◽  
Follicular Carcinoma ◽  
Scoring Systems ◽  
Survival Prediction ◽  
Tnm System ◽  
Cox's Regression ◽  
Group 2 ◽  
The One ◽  
Disease Free

PurposeMost prognostic systems for differentiated carcinoma have been designed for papillary carcinoma.ObjectiveTo analyze the value of the existing prognostic systems for evaluating follicular carcinoma and to determine whether any of them have a better predictive effect.MethodsA total of 66 follicular carcinomas were analyzed. The following prognostic systems were studied: EORTC, AGES, AMES, MACIS, TNM, and NTCTCS.ResultsThe AGES and AMES systems did not demonstrate a good prognostic correlation. In the EORTC system, the rate of disease-free patients was 89% in group 1, 75% in group 2, 69% in group 3, and 0% in group 4. The MACIS system showed 83, 60, 67, and 0% of disease-free patients respectively. The TNM system showed 81, 71, 50, and 0% of disease-free patients respectively. Finally, the NTCTCS system demonstrated 100, 84, 53, and 0% of disease-free patients respectively. Cox's regression analysis was used to calculate the proportion of variation in survival time explained (PVE). The prognostic classification system with the greatest survival prediction was EORTC at 67.64% of PVE, followed by TNM at 62.5% of PVE, and MACIS at 57.82% of PVE.ConclusionsMACIS and TNM are good prognostic systems for evaluating follicular thyroid carcinoma, although the one with the most prognostic value was the EORTC system.

scholarly journals SUN-481 A Coexisting Primary Papillary Thyroid Carcinoma in a Case of Malignant Struma Ovarii with Follicular Thyroid Carcinoma: 2 Types of Thyroid Cancer in the Same Patient

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Ghada Elshimy ◽  
Richa Bhattarai ◽  
Kelvin Tran ◽  
Ricardo Rafael Correa
Keyword(s):  
Thyroid Carcinoma ◽  
Total Thyroidectomy ◽  
Follicular Thyroid Carcinoma ◽  
Thyroid Tissue ◽  
Follicular Carcinoma ◽  
Good Prognosis ◽  
Struma Ovarii ◽  
Malignant Struma Ovarii ◽  
Lymph Node Sampling ◽  
Aortic Lymph Node

Abstract Introduction: Struma ovarii is a rare monodermal variant of ovarian teratoma diagnosed when thyroid tissue is more than 50% of the overall tissue. It represents only 1% of all ovarian tumors. The vast majority of struma ovarii are benign (95%); however, malignant tumors have been reported in a small percentage of cases. The most common type is papillary carcinoma(PTC), followed by typical follicular carcinoma found in the pathology after surgical oophorectomy. We report a case of malignant struma ovarii with follicular carcinoma in the setting of additional micro PTC found after total thyroidectomy. Case report: A 48-year-old female presented with right-sided pelvic pain and a mobile pelvic mass. Pelvic MRI showed noted a large complex solid mass with cystic components in the right adnexa. It measured 7.7 x 8.4 x 6.7 cm. Subsequently, the patient underwent a robotic hysterectomy, bilateral salpingo-oophorectomy (TAHBSO), bilateral pelvic and para-aortic lymph node sampling, omentectomy and resection of nodules. Final pathology noted an ovary with struma ovarii with well-differentiated follicular carcinoma, peritoneal nodules containing thyroid tissue and benign lymph nodes. Subsequently, iodine 123 SPECT CT showed physiologic uptake in the thyroid with increased uptake in the pelvis, right perirectal region indicating residual thyroid tissue. The patient underwent total thyroidectomy with radioactive ablation with I131 (154.7 mCi). Pathology detected incidental 0.5mm micro PTC and it was classified as staged pT1aN. 6 months postoperatively, thyroglobulin (Tg) and Tg antibodies were undetectable with no abnormalities found on repeat whole-body scans. The patient has been following up with no new issues for the past 5 years indicating a good prognosis with low risk of recurrence. Discussion and Conclusion: In the literature, Struma ovarii containing thyroid-type carcinoma and papillary or follicular thyroid carcinoma metastasizing to the ovary has been documented. The standard treatment of a patient with malignant struma ovarii is TAHBSO and complete surgical staging, including peritoneal washings for cytology, pelvic and para-aortic lymph node sampling, and omentectomy. In cases with the residual malignant disease after surgery, total thyroidectomy and radioactive ablation are recommended. Our case is a unique case given the presence of 2 different thyroid carcinoma in the same patient. In addition, our patient had multiple risk factors for recurrence including large lesions&gt;4 cm, extra ovarian extension, and the coexisting synchronous primary thyroid cancer, however, she had a good prognosis with no recurrence during the 5 years follow up period.

scholarly journals A Tale of Three Cases When Thyroid Cancer Does Not Exist but Metastases Do. A Three-Case Series of Metastatic Follicular Thyroid Carcinoma

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A880-A881
Author(s):  
Anna Ziganshina ◽  
Rupinder Kaur Brar ◽  
Ami Amin ◽  
Timothy Jennings ◽  
Hassan Shawa
Keyword(s):  
Thyroid Carcinoma ◽  
Pathological Fracture ◽  
Follicular Thyroid Carcinoma ◽  
Case Series ◽  
Follicular Adenoma ◽  
Follicular Carcinoma ◽  
Pathology Report ◽  
Completion Thyroidectomy ◽  
Hyperplastic Nodule ◽  
Nodular Hyperplasia

Abstract Background: Follicular and papillary thyroid carcinomas represent the majority of all malignancies of the thyroid gland. However, follicular thyroid carcinoma (FTC) is much more difficult to diagnose and manage than its papillary counterpart. Among other factors this could be explained by changing diagnostic criteria and by FTC potential for remote distant and often unpredictable metastases sites. Clinical Cases: In our high volume major academic referral center we have encountered three intriguing cases of metastatic FTC with negative surgical thyroid pathology. The first patient is a 61-year-old woman, who at age 50 was diagnosed with 5.4x3.5x4.2 cm left thyroid nodule (TN). FNAB reported hyperplastic nodule versus follicular neoplasm, subsequent surgical pathology report after lobectomy showed hyperplastic nodule. At age 58 she developed a pathological fracture of the 5th thoracic vertebra and pathology report indicated follicular carcinoma of thyroid origin. TG level at this time was 577 ng/ml. Pathology report from completion thyroidectomy again showed nodular hyperplasia, but reexamination of previously resected lobe demonstrated minimally invasive FTC. The second patient is an 83-year-old woman who at age 68 underwent lobectomy for left sided-goiter, pathology report showed benign follicular adenoma. At age 77 she was found to have right-sided skull mass which was determined to be a follicular carcinoma of thyroid origin. Pathology report from completion thyroidectomy was consistent with nodular hyperplasia. At age 82 the patient was noticed to have increased RAI uptake in thyroid bed, sternum, kidneys, and gastroesophageal junction. TG level at this time was 2214 ng/ml. The third patient is a 56-year-old woman initially diagnosed with a 3.5x2.8x2.2cm right TN at age 53. Lobectomy, performed for diagnostic and therapeutic purposes, showed benign follicular adenoma. At age 56 she developed a pathological fracture of the 3rd thoracic vertebra, follicular carcinoma of thyroid origin was shown on pathology report. TG level at this time was 1694 ng/ml. The patient underwent completion thyroidectomy demonstrating multinodular hyperplasia. Conclusion: This case series emphasizes on the pitfalls of follicular neoplasms diagnosis and management. We suggest prolonged clinical and biochemical surveillance of the patients with what appears to be follicular adenoma after lobectomy. Following serum thyroglobulin perhaps represents the most cost-effective surveillance approach of those patients.

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