Topical active H1-antihistamines and their effect on nasal airway resistance

AbstractThe introduction of a topically active H1-antihistamine nasal spray Azelastine, has given an extra dimension in the management of allergic rhinits. The drug acts rapidly and avoids the sustemic adverse effects of antihistimines. An objective prospective study was performed to detect the effect of Azelastine nasal spray on nasal airway resistance. Twelve healthy adult volunteers with no rhinological problems were included in the study. Nasal cavites were sprayed with 280 μg (two puffs) of Azelastine nasal spray and the nasal airway resistance was measured with anterior rhinomanometry at intervals of 30 minutes for up to two hours. Our study has shown statistically significant increase in the total nasal airway resistance following the use orf Azelastine nasal spray in the absence of a subjective change in nasal airway resistance. There are substances when inhaled which can cause subjective improvement in nasal airway patency without changing the measured nasal airway resistance. However this medication gives no subjective change in nasal airway patency in spite of increasing nasal airway resistance.

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Role of the Nasal Airway in Regulation of Airway Resistance During Hypercapnia and Exercise Second-Place Resident Award at 1982 Research Forum

Otolaryngology ◽

10.1177/019459988409200311 ◽

1984 ◽

Vol 92 (3) ◽

pp. 302-307 ◽

Cited By ~ 9

Author(s):

Janet S. Mertz ◽

Thomas V. Mccaffrey ◽

Eugene B. Kern

Keyword(s):

Airway Resistance ◽

Healthy Adult ◽

Minute Ventilation ◽

Respiratory Center ◽

Nasal Airway ◽

Nasal Resistance ◽

Adult Volunteers

Posterior mask rhinomanometry was used to measure nasal resistance during exercise and hypercapnia in 10 healthy adult volunteers. Exercise was produced by peddling a stationary bicycle at three loads. Hypercapnia was produced by breathing O2 mixtures containing 5%, 6%, and 8% CO2. The results showed that (1) nasal resistance decreases linearly as expired CO2 levels and exercise levels increase, (2) minute ventilation increases linearly as expired CO2 levels and exercise levels increase, and (3) nasal resistance varies inversely with minute ventilation during both hypercapnia and exercise. The constant relationship between nasal resistance and minute ventilation during hypercapnia and exercise suggests that nasal resistance is regulated by the respiratory center to match the level of respiratory demand.

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Component Approach for Partitioning Nasal Airway Resistance: Pharyngeal Flap Case Studies

The Cleft Palate-Craniofacial Journal ◽

10.1597/1545-1569_1993_030_0078_cafpna_2.3.co_2 ◽

1993 ◽

Vol 30 (1) ◽

pp. 78-81 ◽

Cited By ~ 3

Author(s):

Bonnie E. Smith ◽

Thomas W. Guyette

Keyword(s):

Nasal Cavity ◽

Case Studies ◽

Airway Resistance ◽

Clinical Report ◽

Nasal Airway ◽

Airway Patency ◽

Nasal Airway Resistance ◽

Before And After ◽

Component Approach ◽

Pharyngeal Flap

Individuals with craniofacial anomalies often have nasal cavity and/or velopharyngeal constriction. The purpose of this clinical report was to illustrate a technique for partitioning nasal airway resistance into its nasal cavity and velo pharyngeal components. This information would be helpful in determining intervention to reduce high nasal airway resistance as well as in providing information about the outcome of corrective procedures to establish velopharyngeal competence for speech. Data from two pharyngeal flap patients seen before and after surgery were utilized in this illustration. These case studies illustrate the usefulness of component resistance measures in quantifying nasal airway patency before and after corrective surgery for velopharyngeal function.

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Analysis of Nasal Airway Resistance in Normal Healthy Adult Population of Raipur in Chhattisgarh by Rhinomanometry

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2019/551 ◽

2019 ◽

Vol 8 (32) ◽

pp. 2530-2533

Author(s):

Shailendra Gupta ◽

Anupam Minj ◽

Vidyabhushan Vidyabhushan

Keyword(s):

Airway Resistance ◽

Healthy Adult ◽

Adult Population ◽

Nasal Airway ◽

Nasal Airway Resistance

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Objective assessment of nasal resistance among electronic cigarette users

The Journal of Laryngology & Otology ◽

10.1017/s0022215121001432 ◽

2021 ◽

pp. 1-4

Author(s):

S W Lim ◽

AB Zulkiflee

Keyword(s):

Tobacco Smoking ◽

Repeated Measures ◽

Airway Resistance ◽

Electronic Cigarettes ◽

Objective Assessment ◽

Control Group ◽

Nasal Airway ◽

Nasal Resistance ◽

Short Term ◽

Nasal Airway Resistance

Abstract Background Electronic cigarettes have been a popular alternative to tobacco smoking. The effect of tobacco smoking on nasal airway resistance has been investigated before; however, the effect of the aerosol generated by electronic cigarettes is still unknown. This study aimed to evaluate the short-term effects of e-cigarettes on nasal airway resistance. Methods Sixty-one participants were recruited into a vapers group and a control group. The vapers group was instructed to smoke for 5 minutes, and their nasal resistance was measured pre-procedure and at 1 and 5 minutes post-procedure. The results were compared between both groups. Results Repeated measures analysis of variance demonstrated that vaping has no statistically significant effect on total nasal airway resistance. Conclusion Although the differences between both groups were not statistically significant overall, the vapers group showed a reduction in nasal airway resistance in the short term.

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Evaluation of Nasal Passage Patency after Antigen and Histamine Challenge in Guinea Pigs by Acoustic Rhinometry

American Journal of Rhinology ◽

10.2500/105065897781446856 ◽

1997 ◽

Vol 11 (1) ◽

pp. 85-90 ◽

Cited By ~ 9

Author(s):

Setsuo Nakamoto ◽

Yasuo Sakakura ◽

Ole F. Pedersen ◽

Kotaro Ukai

Keyword(s):

Nasal Cavity ◽

Guinea Pigs ◽

Airway Resistance ◽

Cross Sectional Area ◽

Nasal Passage ◽

Nasal Airway ◽

Sectional Area ◽

Cross Sectional ◽

Percent Change ◽

Nasal Airway Resistance

We investigated the effects of antigen and histamine on the nasal passage patency in guinea pigs with or without nasal allergy. The change of nasal patency was measured by acoustic rhinometry and nasal airway resistance. Acoustic reflections have been used in adult humans to determine nasal cavity dimensions in terms of cross-sectional areas as a function of the distance from the nostril. In order to measure nasal cavity dimensions in guinea pigs, we modified equipment for use in humans by decreasing sound tube dimensions, increasing sampling frequency, and applying a special nosepiece. The percent change of volume, minimum cross-sectional area, and nasal airway resistance showed the largest changes at 10 minutes after antigen challenge in sensitized guinea pigs. There was a significant correlation between the individual percent change of nasal airway resistance and volume or minimum cross-sectional area. Histamine, 102 to 105 μg/mL, caused a dose-dependent reduction in percent change of volume in the challenged side of nonsensitized guinea pigs, but not in the opposite side. These results indicate that the noninvasive acoustic reflections technique is useful in small experimental animals, especially to assess the effect of nasal cavity dimensions after the challenge of antigen or nonspecific stimuli.

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