scholarly journals Investigation of the relationship between neutrophil-to-lymphocyte ratio and obstructive sleep apnoea syndrome

2015 ◽  
Vol 129 (12) ◽  
pp. 1251-1251
Author(s):  
S S Bakshi
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Sleep Apnoea ◽  
Neutrophil To Lymphocyte Ratio ◽  
Obstructive Sleep Apnoea Syndrome ◽  
Lymphocyte Ratio ◽  
Sleep Apnoea Syndrome ◽  
Obstructive Sleep ◽  
The Relationship

Investigation of the relationship between neutrophil-to-lymphocyte ratio and obstructive sleep apnoea syndrome

2015 ◽  
Vol 129 (9) ◽  
pp. 887-892 ◽  
Author(s):  
A Yenigun ◽  
H Karamanli
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Sleep Apnoea ◽  
Neutrophil To Lymphocyte Ratio ◽  
Obstructive Sleep Apnoea Syndrome ◽  
Lymphocyte Ratio ◽  
Sleep Apnoea Syndrome ◽  
Group 4 ◽  
Obstructive Sleep

AbstractObjective:To investigate the neutrophil-to-lymphocyte ratio and sleep apnoea severity relationship.Methods:Patients (n= 178) were assigned to five groups according to apnoea–hypopnea indices and continuous positive airway pressure use. White blood cell, neutrophil, lymphocyte and neutrophil-to-lymphocyte ratio values were compared for each group.Results:The neutrophil-to-lymphocyte ratio values of severe obstructive sleep apnoea syndrome patients (group 4) were significantly higher than those of: control patients (group 1), mild obstructive sleep apnoea syndrome patients (group 2) and patients treated with continuous positive airway pressure (group 5) (p= 0.008,p= 0.008 andp= 0.003). Minimum oxygen saturation values of group 4 were significantly lower than those of groups 1, 2 and 5 (p= 0.0005,p= 0.011 andp= 0.001). There was a positive correlation between apnoea–hypopnea index and neutrophil-to-lymphocyte ratio (r = 0.758,p= 0.034), and a negative correlation between apnoea–hypopnea index and minimum oxygen saturation (r = −0.179,p= 0.012).Conclusion:Neutrophil-to-lymphocyte ratio may be used to determine disease severity, complementing polysomnography.

What Non-Alcoholic Fatty Liver Disease Has Got to Do with Obstructive Sleep Apnoea Syndrome and viceversa?

2014 ◽  
Vol 23 (3) ◽  
pp. 291-299 ◽  
Author(s):  
Giovanni Tarantino ◽  
Vincenzo Citro ◽  
Carmine Finelli
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Obstructive Sleep Apnoea ◽  
Fatty Liver Disease ◽  
Sleep Apnoea ◽  
Obstructive Sleep Apnoea Syndrome ◽  
Alcoholic Fatty Liver ◽  
Sleep Apnoea Syndrome ◽  
Obstructive Sleep ◽  
Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) and obstructive sleep apnoea syndrome (OSAS) are common conditions, frequently encountered in patients with obesity and/or metabolic syndrome. NAFLD and OSAS are complex diseases that involve an interaction of several intertwined factors. Several lines of evidence lend credence to an immune system derangement in these patients, i.e. the low grade chronic inflammation status, reckoned to be the most important factor in causing and maintaining these two illnesses. Furthermore, it is emphasized the main role of spleen involvement, as a novel mechanism. In this review the contribution of the visceral adiposity in both NAFLD and OSAS is stressed as well as the role of intermittent hypoxia. Finally, a post on the prevention of systemic inflammation is made.Abbreviations: ALT: alanine aminotransferase; BMI: body mass index; CCR2: chemokine (C-C motif) receptor 2; CRP: C-reactive protein; CPAP: continuous positive airway pressure; FFA: free fatty acid; IGF-I: insulin-like growth factor; IR: insulin resistance; IL-6: interleukin-6; IH: intermittent hypoxia; IKK-β: IκB kinase β; LPS: lipopolysaccharide; MCP-1: monocyte chemoattractant protein-1; NAFLD: non-alcoholic fatty liver disease; NASH: nonalcoholic steatohepatitis; NEFA: non-esterified fatty acid; NF-κB: nuclear factor-κB; OSAS: obstructive sleep apnoea syndrome; PAI-1: plasminogen activator inhibitor-1; ROS: reactive oxygen species; TNF-α: tumor necrosis factor-α; T2D: type 2 diabetes.

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