Short-term weight gain after adenotonsillectomy in children with obstructive sleep apnoea: systematic review

2015 ◽  
Vol 130 (3) ◽  
pp. 214-218 ◽  
Author(s):  
M Van ◽  
I Khan ◽  
S S M Hussain
Keyword(s):  
Weight Gain ◽  
Obstructive Sleep Apnoea ◽  
Controlled Trial ◽  
Paediatric Population ◽  
Sleep Apnoea ◽  
Current Evidence ◽  
Short Term ◽  
Obstructive Sleep ◽  
Before And After ◽  
Randomised Controlled

AbstractBackground:Children with obstructive sleep apnoea commonly undergo adenotonsillectomy as first-line surgical treatment. This paper aimed to investigate whether this intervention was associated with weight gain after surgery in the paediatric population with obstructive sleep apnoea.Method:Two independent researchers systematically reviewed the literature from 1995 to 2014 for studies on patients who underwent adenotonsillectomy with weight-based measurements before and after surgery. The databases used were Ovid Medline, Embase and PubMed.Results:Six papers satisfied all inclusion criteria. Four of these papers showed a significant weight increase and the others did not. The only high quality, randomised, controlled trial showed a significant increase of weight gain at seven months follow up, even in patients who were already overweight before their surgery.Conclusion:The current evidence points towards an association between adenotonsillectomy and weight gain in patients with obstructive sleep apnoea in the short term.

scholarly journals Effect of mandibular advancement therapy on inflammatory and metabolic biomarkers in patients with severe obstructive sleep apnoea: a randomised controlled trial

Thorax ◽  
2018 ◽  
Vol 74 (5) ◽  
pp. 496-499 ◽  
Author(s):  
Sylvain Recoquillon ◽  
Jean-Louis Pépin ◽  
Bruno Vielle ◽  
Ramaroson Andriantsitohaina ◽  
Vanessa Bironneau ◽  
...  
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Controlled Trial ◽  
Sleep Apnoea ◽  
Mandibular Advancement ◽  
Glucose And Lipid Metabolism ◽  
Obstructive Sleep ◽  
Before And After ◽  
Registration Number ◽  
Randomised Controlled ◽  
Factor Α

Systemic inflammation and metabolic disorders are among the mechanisms linking obstructive sleep apnoea (OSA) and cardiovascular disease (CVD). In 109 patients with severe OSA and no overt CVD, biomarkers of inflammation (C reactive protein, interleukin-6, tumour necrosis factor-α and its receptors, adiponectin, leptin and P-selectin), glucose and lipid metabolism, and N-terminal pro-brain natriuretic peptide, were measured before and after 2 months of treatment with a mandibular advancement device (MAD) (n=55) or a sham device (n=54). MAD reduced the Apnoea–Hypopnoea Index (p<0.001) but had no effect on circulating biomarkers compared with the sham device, despite high treatment adherence (6.6 hour/night).Trial registration numberNCT01426607.

scholarly journals A short-term controlled trial of an adjustable oral appliance for the treatment of mild to moderate obstructive sleep apnoea

Thorax ◽  
1997 ◽  
Vol 52 (4) ◽  
pp. 362-368 ◽  
Author(s):  
K. A. Ferguson ◽  
T. Ono ◽  
A. A. Lowe ◽  
S. al-Majed ◽  
L. L. Love ◽  
...  
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Controlled Trial ◽  
Oral Appliance ◽  
Sleep Apnoea ◽  
Short Term ◽  
Obstructive Sleep
Sign in / Sign up

Export Citation Format

Share Document