Role of local allergic inflammation and Staphylococcus aureus enterotoxins in Chinese patients with chronic rhinosinusitis with nasal polyps

2017 ◽  
Vol 131 (8) ◽  
pp. 707-713 ◽  
Author(s):  
K-J Cheng ◽  
Y-Y Xu ◽  
M-L Zhou ◽  
S-H Zhou ◽  
S-Q Wang
Keyword(s):  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Immunoglobulin E ◽  
Allergic Inflammation ◽  
Staphylococcal Enterotoxin ◽  
Eosinophilic Chronic Rhinosinusitis ◽  
Specific Immunoglobulin E ◽  
Specific Immunoglobulin ◽  
Local Allergy

AbstractObjective:To investigate the role of local allergic inflammation and Staphylococcus aureus enterotoxins in chronic rhinosinusitis with nasal polyps.Methods:This study included 36 patients with chronic rhinosinusitis with nasal polyps and 18 controls. Total immunoglobulin E, eosinophil cationic protein, staphylococcal enterotoxin types A and B specific immunoglobulin E, staphylococcal enterotoxin types A and B, and myeloperoxidase levels were determined.Results:Four patients with chronic rhinosinusitis with nasal polyps had a local allergy. All chronic rhinosinusitis with nasal polyps patients tested negative for staphylococcal enterotoxin types A and B specific immunoglobulin E. The chronic rhinosinusitis with nasal polyps group had significantly elevated staphylococcal enterotoxin types A and B levels in the supernatant. Fourteen patients belonged to the eosinophilic chronic rhinosinusitis with nasal polyps group and the others were characterised as having non-eosinophilic chronic rhinosinusitis with nasal polyps.Conclusion:Local allergy may play a role in chronic rhinosinusitis with nasal polyps, independent of staphylococcal enterotoxin superantigens. Staphylococcal enterotoxins may be important in the pathogenesis of chronic rhinosinusitis with nasal polyps; however, their roles as superantigens were not confirmed in this study. In Chinese subjects, chronic rhinosinusitis with nasal polyps usually manifests as a neutrophilic inflammation.

scholarly journals Aeroallergen sensitization profile in medically resistant chronic rhinosinusitis

2020 ◽  
Vol 8 ◽  
pp. 205031212093380
Author(s):  
Haitham Odat ◽  
Maulla Alali ◽  
Mohannad Al-Qudah
Keyword(s):  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Immunoglobulin E ◽  
Academic Center ◽  
Significant Difference ◽  
Specific Immunoglobulin E ◽  
Specific Immunoglobulin ◽  
Inhalant Allergens ◽  
Blood Eosinophils

Objectives: The aim of this study is to report the aeroallergen sensitization profile in medically resistant chronic rhinosinusitis with or without nasal polyps and its relationship to asthma. Methods: Retrospective charts review of 402 chronic rhinosinusitis patients who failed to respond to medical treatment and scheduled for surgery at a tertiary academic center was performed. One hundred and fifty-five patients had chronic rhinosinusitis with nasal polyps and 247 patients had chronic rhinosinusitis without nasal polyps, furthermore; the two phenotypes were subdivided according to the presence or absence of asthma. Allergen-specific immunoglobulin E to 24 inhalant allergens was measured to all patients by the enzyme allergo-sorbent test. Results: The average age was 35 years ( SD ± 13) with 236 males and 166 females. Two hundred and fifty-three patients (63%) were tested positive for at least one allergen with no significant difference between patients with or without polyp (in chronic rhinosinusitis with nasal polyps, 103 patients (66%) were positive compared with 150 patients (61%) in chronic rhinosinusitis without nasal polyps). There were no significant differences in the prevalence, type, and number of positive allergens between the two phenotypes. The prevalence of asthma was found to be 19% in patients with chronic rhinosinusitis without nasal polyps versus 46% in those with chronic rhinosinusitis with nasal polyps ( p = 0.001), and the prevalence of high eosinophils was 27%, and 47% in both phenotypes, respectively ( p = 0.0001). Conclusions: The prevalence of inhalational allergy in medically resistant chronic rhinosinusitis is high, however, this profile does not differ based on the presence of polyp. Patients with chronic rhinosinusitis with nasal polyps had a higher prevalence of asthma and blood eosinophils as compared with chronic rhinosinusitis without nasal polyps. Our results showed a little role of inhalant allergens in nasal polyps or asthma comorbidity in refractory sinusitis patients.

scholarly journals Local fungus-specific Immunoglobulin E production in chronic rhinosinusitis with nasal polyps

2020 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Y. Ohki ◽  
Y. Okamoto ◽  
T. Iinuma ◽  
H. Yamamoto ◽  
T. Toyotome ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Immunoglobulin E ◽  
Specific Immunoglobulin E ◽  
Specific Immunoglobulin

scholarly journals Association of Specific Immunoglobulin E to Staphylococcal Enterotoxin with Airway Hyperresponsiveness in Asthma Patients

2016 ◽  
Vol 79 (4) ◽  
pp. 295 ◽  
Author(s):  
Seong Han Kim ◽  
Seo Yeon Yang ◽  
Jihong You ◽  
Sang Bae Lee ◽  
Jin You ◽  
...  
Keyword(s):  
Airway Hyperresponsiveness ◽  
Immunoglobulin E ◽  
Staphylococcal Enterotoxin ◽  
Specific Immunoglobulin E ◽  
Specific Immunoglobulin ◽  
Asthma Patients

scholarly journals A Potential Role of Group 2 Innate Lymphoid Cells in Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

2021 ◽  
Vol 13 (3) ◽  
pp. 363
Author(s):  
Yan Li ◽  
Wei Wang ◽  
Sun Ying ◽  
Feng Lan ◽  
Luo Zhang
Keyword(s):  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Potential Role ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Eosinophilic Chronic Rhinosinusitis ◽  
Group 2

scholarly journals Role of specific immunoglobulin E in diagnosis of acute toxoplasma infection and toxoplasmosis.

1993 ◽  
Vol 31 (11) ◽  
pp. 2952-2959 ◽  
Author(s):  
S Y Wong ◽  
M P Hajdu ◽  
R Ramirez ◽  
P Thulliez ◽  
R McLeod ◽  
...  
Keyword(s):  
Immunoglobulin E ◽  
Toxoplasma Infection ◽  
Specific Immunoglobulin E ◽  
Specific Immunoglobulin

Tissue-Specific Immunoglobulin E in Human Nasal Polyps

2005 ◽  
Vol 114 (5) ◽  
pp. 386-389 ◽  
Author(s):  
Chih-Yen Wei ◽  
Sheen-Yie Fang
Keyword(s):  
Nasal Polyps ◽  
Immunoglobulin E ◽  
Tissue Homogenate ◽  
Test Results ◽  
Allergic Symptoms ◽  
Specific Immunoglobulin E ◽  
Positive Serum ◽  
Specific Immunoglobulin ◽  
Polyp Tissue ◽  
Polyp Recurrence

Allergy is generally believed to be an underlying cause of nasal polyps. The objective of this study was to define allergic nasal polyps. We investigated specific immunoglobulin E (sIgE) in polyp tissue. Thirty pieces of polyp tissue were taken from patients with positive allergic symptoms, and 30 from patients without allergic symptoms. Nasal polyp tissue homogenate and serum from these patients were prepared for detecting sIgE by a CAP method. For patients with allergic symptoms and/or positive serum CAP test results, the rates of positive tissue CAP tests were low: 36.7% and 35.7%, respectively. However, nearly all of the tissue CAP-positive subjects had allergic symptoms and positive serum CAP tests. We conclude that the local tissue sIgE profile reflects more specifically the allergic status of patients with nasal polyps than does the systemic serum test or the presentation of allergic symptoms. Thus, polyp tissue CAP tests might be performed in patients with positive allergic symptoms and positive serum CAP tests to define an allergy-induced polyp precisely. Then, specific antiallergic treatment could be administered to prevent polyp recurrence.

Role of platelet-derived growth factor-α in eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps

2014 ◽  
Vol 4 (11) ◽  
pp. 909-914 ◽  
Author(s):  
Hai Lin ◽  
Dong Lin ◽  
Xi-Sheng Xiong ◽  
Xiong-Xiong Dai ◽  
Ting Lin
Keyword(s):  
Growth Factor ◽  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Platelet Derived Growth Factor ◽  
Eosinophilic Chronic Rhinosinusitis ◽  
Factor Α

Mucosal Allergy in the Absence of Systemic Allergy in Nasal Polyposis and Rhinitis: A Meta-Analysis

1994 ◽  
Vol 111 (5) ◽  
pp. 553-556 ◽  
Author(s):  
Judith S. Shatkin ◽  
Kathelune G. Delsupehe ◽  
Ronald A. Thisted ◽  
Jacquelynne P. Corey
Keyword(s):  
Nasal Polyp ◽  
Literature Search ◽  
Nasal Polyposis ◽  
Immunoglobulin E ◽  
Meta Analysis ◽  
Specific Immunoglobulin E ◽  
Specific Immunoglobulin ◽  
Different Populations

To better determine the role of allergy in rhinitis and nasal polyposis, we assessed the prevalence of nasal mucosal allergy in the absence of systemic allergy. After a thorough literature search we complied and analyzed data from nine studies (287 patients) that tested for specific immunoglobulin E both intranasally and systemically. When meta-analysis was applied to the different populations, 19% of those who demonstrated specific immunoglobulin E manifested nasal mucosal allergy but no systemic allergy. We suggest that there to an important segment of rhinitis and nasal polyp patients who have nasal mucosal allergy.

Expression and Role of BAG-1 in Eosinophilic and Non-eosinophilic Chronic Rhinosinusitis with Nasal Polyps

Inflammation ◽  
2014 ◽  
Vol 37 (6) ◽  
pp. 1912-1918 ◽  
Author(s):  
Dong Lin ◽  
Hai Lin ◽  
Xisheng Xiong
Keyword(s):  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Eosinophilic Chronic Rhinosinusitis
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