Aeroallergen sensitization profile in medically resistant chronic rhinosinusitis

Objectives: The aim of this study is to report the aeroallergen sensitization profile in medically resistant chronic rhinosinusitis with or without nasal polyps and its relationship to asthma. Methods: Retrospective charts review of 402 chronic rhinosinusitis patients who failed to respond to medical treatment and scheduled for surgery at a tertiary academic center was performed. One hundred and fifty-five patients had chronic rhinosinusitis with nasal polyps and 247 patients had chronic rhinosinusitis without nasal polyps, furthermore; the two phenotypes were subdivided according to the presence or absence of asthma. Allergen-specific immunoglobulin E to 24 inhalant allergens was measured to all patients by the enzyme allergo-sorbent test. Results: The average age was 35 years ( SD ± 13) with 236 males and 166 females. Two hundred and fifty-three patients (63%) were tested positive for at least one allergen with no significant difference between patients with or without polyp (in chronic rhinosinusitis with nasal polyps, 103 patients (66%) were positive compared with 150 patients (61%) in chronic rhinosinusitis without nasal polyps). There were no significant differences in the prevalence, type, and number of positive allergens between the two phenotypes. The prevalence of asthma was found to be 19% in patients with chronic rhinosinusitis without nasal polyps versus 46% in those with chronic rhinosinusitis with nasal polyps ( p = 0.001), and the prevalence of high eosinophils was 27%, and 47% in both phenotypes, respectively ( p = 0.0001). Conclusions: The prevalence of inhalational allergy in medically resistant chronic rhinosinusitis is high, however, this profile does not differ based on the presence of polyp. Patients with chronic rhinosinusitis with nasal polyps had a higher prevalence of asthma and blood eosinophils as compared with chronic rhinosinusitis without nasal polyps. Our results showed a little role of inhalant allergens in nasal polyps or asthma comorbidity in refractory sinusitis patients.

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Role of local allergic inflammation and Staphylococcus aureus enterotoxins in Chinese patients with chronic rhinosinusitis with nasal polyps

The Journal of Laryngology & Otology ◽

10.1017/s0022215117001335 ◽

2017 ◽

Vol 131 (8) ◽

pp. 707-713 ◽

Cited By ~ 5

Author(s):

K-J Cheng ◽

Y-Y Xu ◽

M-L Zhou ◽

S-H Zhou ◽

S-Q Wang

Keyword(s):

Chronic Rhinosinusitis ◽

Nasal Polyps ◽

Immunoglobulin E ◽

Allergic Inflammation ◽

Staphylococcal Enterotoxin ◽

Eosinophilic Chronic Rhinosinusitis ◽

Specific Immunoglobulin E ◽

Specific Immunoglobulin ◽

Local Allergy

AbstractObjective:To investigate the role of local allergic inflammation and Staphylococcus aureus enterotoxins in chronic rhinosinusitis with nasal polyps.Methods:This study included 36 patients with chronic rhinosinusitis with nasal polyps and 18 controls. Total immunoglobulin E, eosinophil cationic protein, staphylococcal enterotoxin types A and B specific immunoglobulin E, staphylococcal enterotoxin types A and B, and myeloperoxidase levels were determined.Results:Four patients with chronic rhinosinusitis with nasal polyps had a local allergy. All chronic rhinosinusitis with nasal polyps patients tested negative for staphylococcal enterotoxin types A and B specific immunoglobulin E. The chronic rhinosinusitis with nasal polyps group had significantly elevated staphylococcal enterotoxin types A and B levels in the supernatant. Fourteen patients belonged to the eosinophilic chronic rhinosinusitis with nasal polyps group and the others were characterised as having non-eosinophilic chronic rhinosinusitis with nasal polyps.Conclusion:Local allergy may play a role in chronic rhinosinusitis with nasal polyps, independent of staphylococcal enterotoxin superantigens. Staphylococcal enterotoxins may be important in the pathogenesis of chronic rhinosinusitis with nasal polyps; however, their roles as superantigens were not confirmed in this study. In Chinese subjects, chronic rhinosinusitis with nasal polyps usually manifests as a neutrophilic inflammation.

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Local fungus-specific Immunoglobulin E production in chronic rhinosinusitis with nasal polyps

Rhinology Journal ◽

10.4193/rhin18.225 ◽

2020 ◽

Vol 0 (0) ◽

pp. 0-0

Author(s):

Y. Ohki ◽

Y. Okamoto ◽

T. Iinuma ◽

H. Yamamoto ◽

T. Toyotome ◽

...

Keyword(s):

Chronic Rhinosinusitis ◽

Nasal Polyps ◽

Immunoglobulin E ◽

Specific Immunoglobulin E ◽

Specific Immunoglobulin

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Role of specific immunoglobulin E in diagnosis of acute toxoplasma infection and toxoplasmosis.

Journal of Clinical Microbiology ◽

10.1128/jcm.31.11.2952-2959.1993 ◽

1993 ◽

Vol 31 (11) ◽

pp. 2952-2959 ◽

Cited By ~ 50

Author(s):

S Y Wong ◽

M P Hajdu ◽

R Ramirez ◽

P Thulliez ◽

R McLeod ◽

...

Keyword(s):

Immunoglobulin E ◽

Toxoplasma Infection ◽

Specific Immunoglobulin E ◽

Specific Immunoglobulin

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Tissue-Specific Immunoglobulin E in Human Nasal Polyps

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348940511400509 ◽

2005 ◽

Vol 114 (5) ◽

pp. 386-389 ◽

Cited By ~ 6

Author(s):

Chih-Yen Wei ◽

Sheen-Yie Fang

Keyword(s):

Nasal Polyps ◽

Immunoglobulin E ◽

Tissue Homogenate ◽

Test Results ◽

Allergic Symptoms ◽

Specific Immunoglobulin E ◽

Positive Serum ◽

Specific Immunoglobulin ◽

Polyp Tissue ◽

Polyp Recurrence

Allergy is generally believed to be an underlying cause of nasal polyps. The objective of this study was to define allergic nasal polyps. We investigated specific immunoglobulin E (sIgE) in polyp tissue. Thirty pieces of polyp tissue were taken from patients with positive allergic symptoms, and 30 from patients without allergic symptoms. Nasal polyp tissue homogenate and serum from these patients were prepared for detecting sIgE by a CAP method. For patients with allergic symptoms and/or positive serum CAP test results, the rates of positive tissue CAP tests were low: 36.7% and 35.7%, respectively. However, nearly all of the tissue CAP-positive subjects had allergic symptoms and positive serum CAP tests. We conclude that the local tissue sIgE profile reflects more specifically the allergic status of patients with nasal polyps than does the systemic serum test or the presentation of allergic symptoms. Thus, polyp tissue CAP tests might be performed in patients with positive allergic symptoms and positive serum CAP tests to define an allergy-induced polyp precisely. Then, specific antiallergic treatment could be administered to prevent polyp recurrence.

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Association Between Allergen Sensitization and Anaphylaxis in Patients Visiting a Pediatric Emergency Department

Frontiers in Pediatrics ◽

10.3389/fped.2021.651375 ◽

2021 ◽

Vol 9 ◽

Author(s):

Won Seok Lee ◽

Lily Myung-Jin Cha ◽

Man Yong Han ◽

Kyung Suk Lee

Keyword(s):

Immunoglobulin E ◽

Allergic Sensitization ◽

Pediatric Emergency ◽

Allergen Sensitization ◽

Severe Anaphylaxis ◽

Specific Immunoglobulin E ◽

Specific Immunoglobulin ◽

Facial Edema ◽

Inhalant Allergens ◽

Symptoms And Signs

Background and Objectives: Anaphylaxis, a severe allergic disease, can be triggered by various causes. This study investigated the association between allergic sensitization and anaphylactic symptoms and the severity of anaphylaxis in children.Patients and Methods: A retrospective review of 107 pediatric patients with anaphylaxis was performed between January 1, 2015, and December 31, 2017; 74 patients underwent allergen testing for specific immunoglobulin E. Allergic sensitizations and associations with anaphylactic symptoms and severity were investigated.Results: Overall, 64 (86.5%) patients were sensitized to food or inhalant allergens. In children under 2 years of age, 90.5% were sensitized to food (P = 0.001); in those over 6 years of age, 84.6% were sensitized to inhalant allergens (P = 0.001). Milk sensitization was significantly associated with severe anaphylaxis (P = 0.036). The following symptoms showed significant associations with certain allergen sensitizations: facial edema with food; wheezing with milk; dyspnea with mite, etc. Certain allergen sensitizations presenting as risk factors for anaphylactic symptoms: wheat (adjusted odds ratio [aOR] = 4.644, P = 0.044) and nuts (aOR=3.614, P = 0.041) for wheezing, nuts (aOR=5.201, P = 0.026) for dyspnea, and milk (aOR=4.712, P = 0.048) for vomiting.Conclusion: The allergen sensitization status differed according to the age of the children experiencing anaphylaxis. The severity, symptoms, and signs of anaphylaxis differed depending on the allergen sensitization status.

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Mucosal Allergy in the Absence of Systemic Allergy in Nasal Polyposis and Rhinitis: A Meta-Analysis

Otolaryngology ◽

10.1177/019459989411100503 ◽

1994 ◽

Vol 111 (5) ◽

pp. 553-556 ◽

Cited By ~ 20

Author(s):

Judith S. Shatkin ◽

Kathelune G. Delsupehe ◽

Ronald A. Thisted ◽

Jacquelynne P. Corey

Keyword(s):

Nasal Polyp ◽

Literature Search ◽

Nasal Polyposis ◽

Immunoglobulin E ◽

Meta Analysis ◽

Specific Immunoglobulin E ◽

Specific Immunoglobulin ◽

Different Populations

To better determine the role of allergy in rhinitis and nasal polyposis, we assessed the prevalence of nasal mucosal allergy in the absence of systemic allergy. After a thorough literature search we complied and analyzed data from nine studies (287 patients) that tested for specific immunoglobulin E both intranasally and systemically. When meta-analysis was applied to the different populations, 19% of those who demonstrated specific immunoglobulin E manifested nasal mucosal allergy but no systemic allergy. We suggest that there to an important segment of rhinitis and nasal polyp patients who have nasal mucosal allergy.

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Blood Eosinophils, Specific Immunoglobulin E, and Bronchiolitis Severity

Pediatric Pulmonology ◽

10.1002/ppul.25543 ◽

2021 ◽

Author(s):

Elie J. Mitri ◽

David X. Zheng ◽

Vebhav Garg ◽

Cassandra C. Crifase ◽

Nicole M. Herrera ◽

...

Keyword(s):

Immunoglobulin E ◽

Specific Immunoglobulin E ◽

Specific Immunoglobulin ◽

Blood Eosinophils

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The Role of Virus-specific Immunoglobulin E in Airway Hyperresponsiveness

American Journal of Respiratory and Critical Care Medicine ◽

10.1164/rccm.200311-1610oc ◽

2004 ◽

Vol 170 (9) ◽

pp. 952-959 ◽

Cited By ~ 32

Author(s):

Azzeddine Dakhama ◽

Jung-Won Park ◽

Christian Taube ◽

Kosuke Chayama ◽

Annette Balhorn ◽

...

Keyword(s):

Airway Hyperresponsiveness ◽

Immunoglobulin E ◽

Specific Immunoglobulin E ◽

Specific Immunoglobulin

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Ovomucoid Specific Immunoglobulin E as a Predictor of Tolerance to Cooked Egg

Allergy & Rhinology ◽

10.2500/ar.2015.6.0135 ◽

2015 ◽

Vol 6 (3) ◽

pp. ar.2015.6.0135 ◽

Cited By ~ 6

Author(s):

Lisa M. Bartnikas ◽

William J. Sheehan ◽

Katherine L. Tuttle ◽

Carter R. Petty ◽

Lynda C. Schneider ◽

...

Keyword(s):

Operating Characteristic ◽

Immunoglobulin E ◽

Characteristic Curve ◽

Food Challenge ◽

Spearman Correlation ◽

Sige Level ◽

Hen’S Egg ◽

Significant Difference ◽

Specific Immunoglobulin E ◽

Specific Immunoglobulin

Background Ovomucoid is the dominant allergen in hen's egg. Although several studies evaluated the utility of ovomucoid specific immunoglobulin E (sIgE) levels in predicting baked (e.g., muffin or cupcake) or raw egg food challenge outcomes, studies that evaluated ovomucoid sIgE as a predictor of cooked egg (e.g., scrambled or hard boiled) challenge outcomes are limited. Objective To determine the relation of ovomucoid sIgE levels with cooked egg food challenge outcomes. Methods A retrospective review of 44 children who underwent cooked egg food challenge and who had the ovomucoid sIgE level measured. Results Thirty-six of 44 children (81.8%) passed cooked egg challenge. The ovomucoid sIgE level predicted cooked egg challenge outcome (passed median, <0.35 kU/L [range, <0.35–0.64 kU/L]; failed median, 0.40 kU/L [range, <0.35–3.13 kU/L]; p = 0.004). Ovomucoid sIgE levels correlated with egg white (EW) sIgE levels (Spearman correlation coefficient, 0.588; p = 0.001). Receiver operating characteristic curve analysis of ovomucoid and EW sIgE demonstrated areas under the curve of 0.711 and 0.766, respectively. No significant difference was observed among those immunologic parameters in their abilities to predict cooked egg challenge outcome (p = 0.559). Conclusion The ovomucoid sIgE level may be helpful in predicting cooked egg challenge outcomes. However, our study did not support a role for ovomucoid sIgE replacing EW sIgE testing in evaluating egg allergy.

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