scholarly journals A neural efficiency-threshold model to understand psychotic experiences

2021 ◽  
pp. 1-6
Author(s):  
Ian Kelleher ◽  
Mary Cannon
2000 ◽  
Vol 21 (3) ◽  
pp. 200-207
Author(s):  
Aljoscha C. Neubauer ◽  
Dietmar G. Schrausser ◽  
Heribert H. Freudenthaler
Keyword(s):  

Zusammenfassung: Die neural efficiency-Hypothese der menschlichen Intelligenz nimmt an, daß eine wesentliche physiologische Grundlage intelligenten Verhaltens in einer Fokussierung der Aktivierung auf aufgabenrelevante Kortexareale besteht. Eine Bestätigung dieser Vermutung läßt sich aus neueren Studien ableiten, in denen die Aktivierung des gesamten Kortex mittels bildgebender EEG-Verfahren oder der Positronen-Emissions-Tomographie (PET) gemessen wurde. Im Beitrag sollen die wesentlichsten Ergebnisse unserer bisherigen EEG-Studien zu dieser Frage vorgestellt werden. Dabei wurde die durch kognitive Aufgaben ausgelöste Ereignisbezogene Desynchronisation (ERD) im EEG topografisch analysiert und jeweils zwischen zwei Gruppen unterschiedlicher Intelligenz verglichen. Es konnte zumeist beobachtet werden, daß intelligentere Personen ihre kortikale Aktivierung vor allem auf die aufgabenrelevanten Areale fokussieren, während die weniger intelligenten eine eher diffuse Aktivierung aufweisen. Zudem ergaben sich Wechselwirkungen des Faktors Intelligenz mit der Aufgabenkomplexität (Studie 2) und dem Geschlecht (Studie 3). Annahmen darüber, welche Eigenschaften des biologischen Substrats für dieses neural efficiency-Phänomen verantwortlich sein könnten, werden diskutiert.


2014 ◽  
Author(s):  
S. Hartley ◽  
G. Haddock ◽  
D. Vasconcelos e Sa ◽  
R. Emsley ◽  
C. Barrowclough

2019 ◽  
Author(s):  
Susan L. Rossell ◽  
Maya J. L. Schutte ◽  
Wei Lin Toh ◽  
Neil Thomas ◽  
Clara Strauss ◽  
...  

2020 ◽  
Vol 75 (3) ◽  
pp. 204-213
Author(s):  
Varvara A. Ryabkova ◽  
Leonid P. Churilov ◽  
Yehuda Shoenfeld

The pathogenesis of autoimmune diseases is very complex and multi-factorial. The concept of Mosaics of Autoimmunity was introduced to the scientific community 30 years ago by Y. Shoenfeld and D.A. Isenberg, and since then new tiles to the puzzle are continuously added. This concept specifies general pathological ideas about the multifactorial threshold model for polygenic inheritance with a threshold effect by the action of a number of external causal factors as applied to the field of autoimmunology. Among the external factors that can excessively stimulate the immune system, contributing to the development of autoimmune reactions, researchers are particularly interested in chemical substances, which are widely used in pharmacology and medicine. In this review we highlight the autoimmune dynamics i.e. a multistep pathogenesis of autoimmune diseases and the subsequent development of lymphoma in some cases. In this context several issues are addressed namely, genetic basis of autoimmunity; environmental immunostimulatory risk factors; gene/environmental interaction; pre-clinical autoimmunity with the presence of autoantibodies; and the mechanisms, underlying lymphomagenesis in autoimmune pathology. We believe that understanding the common model of the pathogenesis of autoimmune diseases is the first step to their successful management.


2020 ◽  
Vol 89 ◽  
pp. 65-74
Author(s):  
A. G. Zavorotnyy ◽  

Introduction. Operation of radiation hazardous facilities is a reality of the modern world, and the future of the world economy is impossible without the development of nuclear and radiation technologies. At the same time, the widespread use of atomic energy puts forward an important and responsible task of ensuring the safety of the population and the environment in conditions of an increased risk of exposure to ionizing radiation and radioactive substances. In accordance with clause 3.2.1 of the "Radiation Safety Standards NRB-99/2009", the planned increased exposure of persons involved in emergency rescue operations related to the elimination of the consequences of radiation accidents is allowed for men, as a rule, over 30 years old only with their voluntary written consent, after informing about possible radiation doses and health risks. Increased exposure refers to exposure in excess of the basic dose limits under controlled (normal) operating conditions of radiation sources. Goals and objectives. The aim of the study is to increase the functionality of emergency services and fire and rescue subdivisions to perform tasks as intended in the elimination of radiation accidents. The tasks include the construction and substantiation of a model that allows converting the risks of deterministic effects into stochastic effects risks. Methods. When calculating the probability of output of stochastic and deterministic effects depending on the radiation dose and developing a threshold quadratic model, the least squares method and the probabilistic-statistical method were used. Results and discussion. The article shows that a linear non-threshold model of the interaction of radiation with matter greatly overestimates the risk of a stochastic effect emerging at doses of radiation. For example, this overestimation is 8,13 at a dose of D = 0,2 Sv/year. In this regard, a threshold quadratic model has been developed and proposed to be replaced by a threshold quadratic model, which makes it possible to increase the planned irradiation of personnel of emergency services and fire and rescue units during the elimination of radiation accidents in an effective dose from 0,2 Sv to 0,57 Sv, moreover, the probability of emergence of stochastic effects P2 = 0,0084 remains the same for both models. Conclusions. An increase in the maximum permissible dose of radiation for personnel of emergency services and fire and rescue units from 0,2 Sv/year to 0,5 Sv/year will make it possible to increase the functionality of the emergency services and fire and rescue units to perform tasks as intended by 2,5 times when elimination of radiation accidents. For example, the scope of rescue operations may be increased from 100 %, performed at a dose of D = 0,2 Sv/year, to 250 %, performed at a dose of D = 0,5 Sv/year. Key words: emergency services, fire and rescue units, radiation accidents, irradiation, linear no-threshold model, threshold quadratic model.


2010 ◽  
Author(s):  
Sandeep R. Chandukala ◽  
S. Long-Tolbert ◽  
Greg M. Allenby
Keyword(s):  

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