PP008 Health Technology Assessment Analysis Of New Biological Drugs In Chronic Inflammatory Diseases

INTRODUCTION:Innovative therapies with high cost are increasing in every therapeutic area, making it increasingly difficult the role of the pharmacist in trying to rationalize the economic resources to satisfy the needs of the entire population. The analysis of therapeutic appropriateness has a key role in the management of chronic inflammatory diseases where the biological drugs are used by patients for a long period of time. With increasing competition among companies and the advent of the first biosimilar drugs, the costs are declining and the duty of the Pharmacist is the supervision of treatments so that there is a good cost / effectiveness in an attempt to free resources and safeguard the survival of the Health Service National.METHODS:In the year 2015 up to September 2016, all patients were monitored in the departments of Rheumatology, Gastroenterology and Dermatology based on the type of disease, drugs, route of administration and dosages. We evaluated the previous non-biological treatments of first line, therapeutic switch between any drugs with different mechanisms of action, the analysis on the state of the disease, any therapeutic dosages not reported in Summary of Product Characteristics and the reasons that lead the doctors to deviate from guidelines.RESULTS:The treatments of 684 patients were analyzed: 409 in Rheumatology, 212 in Gastroenterology and 63 in Dermatology. The most frequently used drugs are those that have major use in clinical practice: Adalimumab, Etanercept and Infliximab (three anti-TNF alpha drugs). The first two, having a subcutaneous administration compared to intravenous administration, allow greater patient compliance and are therefore preferred to Infliximab. In Rheumatology the use of newer drugs with different mechanisms of action by inhibition of TNF alpha is not negligible and this is an indication of poor accuracy in the application of the guidelines.CONCLUSIONS:Biologicals are well tolerated and improve the quality of life of people with highly disabling diseases. The therapeutic appropriateness and adherence to guidelines are the only way to try to contain costs. The hope is that, in this new year 2017, new biosimilar drugs are approved that would make, at least for the naïve subjects, more sustainable management of these diseases.

Download Full-text

A Novel Fluorescent Probe for Detecting Hydrogen Sulfide in Osteoblasts During Lipopolysaccharide-Mediated Inflammation Under Periodontitis

10.21203/rs.3.rs-776276/v1 ◽

2021 ◽

Author(s):

Xiaoya Lu ◽

Hanchuang Zhu ◽

Yi Chen ◽

Yue Wu ◽

Dongsheng Zhang ◽

...

Keyword(s):

Hydrogen Sulfide ◽

Fluorescence Probe ◽

Inflammatory Diseases ◽

The Novel ◽

Chronic Inflammatory Diseases ◽

Potential Marker ◽

Precise Role

Abstract Periodontitis, one of the most common chronic inflammatory diseases, affects the quality of life. Osteogenesis makes an important role of the disease. There is a connection between hydrogen sulfide (H2S) and periodontitis, but according to the study has been published, the precise role of H2S in inflammation remains in doubt. The main reason of the lack of research is that H2S is an endogenous gasotransmitter, difficult to discern through testing. So, we synthesis a novel fluorescence probe which can detective H2S in vitro. By using the novel H2S fluorescence probe, we found that H2S changes in osteoblasts mainly by cystathionine-γ-lyase, and H2S increases under LPS stimulation. H2S could be a potential marker for diagnosis of inflammatory diseases of bone, and might help deeper studies of the changes of H2S level and promote the progression on the researches about pathogenesis of periodontitis.

Download Full-text

A novel fluorescent probe for detecting hydrogen sulfide in osteoblasts during lipopolysaccharide-mediated inflammation under periodontitis

Scientific Reports ◽

10.1038/s41598-021-99761-4 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Xiaoya Lu ◽

Hanchuang Zhu ◽

Yi Chen ◽

Yue Wu ◽

Dongsheng Zhang ◽

...

Keyword(s):

Hydrogen Sulfide ◽

Fluorescence Probe ◽

Inflammatory Diseases ◽

The Novel ◽

Chronic Inflammatory Diseases ◽

Potential Marker ◽

Precise Role

AbstractPeriodontitis, one of the most common chronic inflammatory diseases, affects the quality of life. Osteogenesis plays an important role in the disease. There is a connection between hydrogen sulfide (H2S) and periodontitis, but according to the study has been published, the precise role of H2S in inflammation remains in doubt. The main reason for the lack of research is that H2S is an endogenous gasotransmitter, difficult to discern through testing. So, we synthesized a novel fluorescence probe which can detect H2S in vitro. By using the novel H2S fluorescence probe, we found that H2S changes in osteoblasts mainly by cystathionine-γ-lyase, and H2S increases under LPS stimulation. H2S could be a potential marker for diagnosis of inflammatory diseases of bone, and might help deepen studies of the changes of H2S level and promote the progression on the researches about pathogenesis of periodontitis.

Download Full-text

Breaking down chronic inflammatory diseases: the role of biglycan in promoting a switch between inflammation and autophagy

FEBS Journal ◽

10.1111/febs.14791 ◽

2019 ◽

Vol 286 (15) ◽

pp. 2965-2979 ◽

Cited By ~ 21

Author(s):

Heiko Roedig ◽

Madalina Viviana Nastase ◽

Malgorzata Wygrecka ◽

Liliana Schaefer

Keyword(s):

Inflammatory Diseases ◽

Chronic Inflammatory Diseases

Download Full-text

Amyloid Proteins and Peripheral Neuropathy

Cells ◽

10.3390/cells9061553 ◽

2020 ◽

Vol 9 (6) ◽

pp. 1553 ◽

Cited By ~ 1

Author(s):

Mohammed M. H. Asiri ◽

Sjoukje Engelsman ◽

Niels Eijkelkamp ◽

Jo W. M. Höppener

Keyword(s):

Peripheral Neuropathy ◽

Potential Role ◽

Inflammatory Diseases ◽

Amyloid Proteins ◽

Chronic Inflammatory Diseases ◽

Histopathological Feature ◽

Common Diseases ◽

Biological Defects

Painful peripheral neuropathy affects millions of people worldwide. Peripheral neuropathy develops in patients with various diseases, including rare familial or acquired amyloid polyneuropathies, as well as some common diseases, including type 2 diabetes mellitus and several chronic inflammatory diseases. Intriguingly, these diseases share a histopathological feature—deposits of amyloid-forming proteins in tissues. Amyloid-forming proteins may cause tissue dysregulation and damage, including damage to nerves, and may be a common cause of neuropathy in these, and potentially other, diseases. Here, we will discuss how amyloid proteins contribute to peripheral neuropathy by reviewing the current understanding of pathogenic mechanisms in known inherited and acquired (usually rare) amyloid neuropathies. In addition, we will discuss the potential role of amyloid proteins in peripheral neuropathy in some common diseases, which are not (yet) considered as amyloid neuropathies. We conclude that there are many similarities in the molecular and cell biological defects caused by aggregation of the various amyloid proteins in these different diseases and propose a common pathogenic pathway for “peripheral amyloid neuropathies”.

Download Full-text

Role of Biofilms in Chronic Inflammatory Diseases of the Upper Airways

Recent Advances in Tonsils and Mucosal Barriers of the Upper Airways - Advances in Oto-Rhino-Laryngology ◽

10.1159/000324622 ◽

2011 ◽

pp. 93-96 ◽

Cited By ~ 6

Author(s):

L. Calò ◽

G.C. Passàli ◽

J. Galli ◽

G. Fadda ◽

G. Paludetti

Keyword(s):

Inflammatory Diseases ◽

Upper Airways ◽

Chronic Inflammatory Diseases

Download Full-text

An update on the role of gut microbiota in chronic inflammatory diseases, and potential therapeutic targets

Expert Review of Gastroenterology & Hepatology ◽

10.1080/17474124.2018.1505497 ◽

2018 ◽

Vol 12 (10) ◽

pp. 969-983 ◽

Cited By ~ 4

Author(s):

Bobbi Laing ◽

Matthew P. G. Barnett ◽

Gareth Marlow ◽

Noha Ahmed Nasef ◽

Lynnette R. Ferguson

Keyword(s):

Gut Microbiota ◽

Inflammatory Diseases ◽

Therapeutic Targets ◽

Chronic Inflammatory Diseases

Download Full-text

The Role of Bile Acid Receptors in Chronic Inflammatory Diseases

Journal of Rheumatic Diseases ◽

10.4078/jrd.2017.24.5.253 ◽

2017 ◽

Vol 24 (5) ◽

pp. 253

Author(s):

Robin Park ◽

Jong Dae Ji

Keyword(s):

Bile Acid ◽

Inflammatory Diseases ◽

Chronic Inflammatory Diseases ◽

Bile Acid Receptors

Download Full-text

The role of DMARDs in reducing the immunogenicity of TNF inhibitors in chronic inflammatory diseases

Rheumatology ◽

10.1093/rheumatology/ket260 ◽

2013 ◽

Vol 53 (2) ◽

pp. 213-222 ◽

Cited By ~ 120

Author(s):

M. Jani ◽

A. Barton ◽

R. B. Warren ◽

C. E. M. Griffiths ◽

H. Chinoy

Keyword(s):

Inflammatory Diseases ◽

Tnf Inhibitors ◽

Chronic Inflammatory Diseases

Download Full-text

Mechanisms Underlying the Antinociceptive, Antiedematogenic, and Anti-Inflammatory Activity of the Main Flavonoid fromKalanchoe pinnata

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2014/429256 ◽

2014 ◽

Vol 2014 ◽

pp. 1-8 ◽

Cited By ~ 18

Author(s):

Raquel Teixeira Ferreira ◽

Marcela Araújo Soares Coutinho ◽

David do Carmo Malvar ◽

Elson Alves Costa ◽

Iziara Ferreira Florentino ◽

...

Keyword(s):

Acetic Acid ◽

Inflammatory Diseases ◽

Subcutaneous Administration ◽

Mechanisms Of Action ◽

Selectivity Index ◽

Kalanchoe Pinnata ◽

Flavonoid Quercetin ◽

Cox 2 ◽

Anti Inflammatory ◽

Cox 1

Kalanchoe pinnata(KP) is popularly used for treating inflammatory diseases. This study investigated the antinociceptive, antiedematogenic, and anti-inflammatory potential of the subcutaneous administration of KP flower aqueous extract (KPFE), its ethyl acetate (EtOAcF) and butanol (BuOHF) fractions, and the main KP flavonoid [quercetin 3-O-α-L-arabinopyranosyl (1→2)α-L-rhamnopyranoside] (KPFV) in mice, as well as its possible mechanisms of action. KPFE (30–300 mg/kg) and KPFV (1–10 mg/kg) inhibited the acetic acid-induced writhing (ID50= 164.8 and 9.4 mg/kg, resp.). KPFE (300 mg/kg), EtOAcF (12 mg/kg), BuOHF (15 mg/kg), or KPFV (0.3–3.0 mg/kg) reduced leukocyte migration on carrageenan-induced pleurisy (ID50= 2.0 mg/kg for KPFV). KPFE (3–30 mg/kg) and KPFV (0.3–3.0 mg/kg) reduced the croton oil-induced ear edema (ID50= 4.3 and 0.76 mg/kg, resp.). KPFE and KPFV reduced the TNF-αconcentration in the pleural exudates on carrageenan-induced pleurisy test. Moreover, KPFV inhibited COX-1 (IC50= 22.1 μg/mL) and COX-2 (IC50> 50 μg/mL). The selectivity index (COX-1IC50/COX-2IC50) was <0.44. These results indicate that KPFE and KPFV produced antinociceptive, antiedematogenic, and anti-inflammatory activities through COX inhibition and TNF-αreduction, revealing that the main flavonoid in KP flowers and leaves plays an important role in the ethnomedicinal use of the plant.

Download Full-text