Cerebral Evoked Potentials in Multiple Sclerosis

ABSTRACT:Multimodal evoked potentials were analyzed from 58 possible, 62 probable and 100 definite (total 220) multiple sclerosis (MS) patients. Visual evoked potentials (VEP) were most frequently abnormal yielding 39%, 69%, 84% in the three diagnostic groups respectively. Median nerve sensory evoked potentials (SEP) yielded abnormalities in 26%, 65%, 79% respectively. Brainstem auditory evoked responses (BAER) were abnormal in 17%, 39%, 66% respectively. We measured the combined amplitude (CA) of waves III, IV, V in the BAER of these patients as an objective measure of amplitude asymmetry. The CA was considered abnormal if it was 1SD below the lowest CA value in the control group. The CA was abnormal in 9.2% of BAER with normal central conduction time. The BAER diagnostic yield in MS patients increased 11% by using CA analysis.

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Sensory evoked potentials to predict short-term progression of disability in multiple sclerosis

Neurological Sciences ◽

10.1007/s10072-011-0862-3 ◽

2011 ◽

Vol 33 (4) ◽

pp. 887-892 ◽

Cited By ~ 14

Author(s):

N. Margaritella ◽

L. Mendozzi ◽

M. Garegnani ◽

E. Colicino ◽

E. Gilardi ◽

...

Keyword(s):

Multiple Sclerosis ◽

Evoked Potentials ◽

Short Term ◽

Sensory Evoked Potentials ◽

Sensory Evoked

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Physiotherapy Approaches in the Treatment of Ataxic Multiple Sclerosis: A Pilot Study

Neurorehabilitation and Neural Repair ◽

10.1177/154596830101500308 ◽

2001 ◽

Vol 15 (3) ◽

pp. 203-211 ◽

Cited By ~ 60

Author(s):

Kadriye Armutlu ◽

Rana Karabudak ◽

Gülay Nurlu

Keyword(s):

Multiple Sclerosis ◽

Evoked Potentials ◽

Motor Evoked Potentials ◽

Control Group ◽

Study Group ◽

Conduction Time ◽

Expanded Disability Status Scale ◽

Gait Parameters ◽

Significant Difference ◽

Disability Status

Objective: This study was planned to investigate the efficacy of neuromuscular rehabilitation and Johnstone Pressure Splints in the patients who had ataxic multiple sclerosis. Methods: Twenty-six outpatients with multiple sclerosis were the subjects of the study. The control group (n = 13) was given neuromuscular rehabilitation, whereas the study group (n = 13) was treated with Johnstone Pressure Splints in ad dition. Results: In pre- and posttreatment data, significant differences were found in sensation, anterior balance, gait parameters, and Expanded Disability Status Scale (p < 0.05). An important difference was observed in walking-on-two-lines data within the groups (p < 0.05). There also was a statistically significant difference in pendular movements and dysdiadakokinesia (p < 0.05). When the posttreatment values were compared, there was no significant difference between sensation, anterior balance, gait parameters, equilibrium and nonequilibrium coordination tests, Expanded Disability Status Scale, cortical onset latency, and central conduction time of somatosensory evoked potentials and motor evoked potentials (p > 0.05). Comparison of values re vealed an important difference in cortical onset-P37 peak amplitude of somatosen sory evoked potentials (right limbs) in favor of the study group (p < 0.05). Conclu sions : According to our study, it was determined that physiotherapy approaches were effective to decrease the ataxia. We conclude that the combination of suitable phys iotherapy techniques is effective multiple sclerosis rehabilitation. Key Words: Multi ple sclerosis—Ataxia—Physical therapy.

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Multicentre assessment of motor and sensory evoked potentials in multiple sclerosis: reliability and implications for clinical trials

Multiple Sclerosis Journal - Experimental Translational and Clinical ◽

10.1177/2055217319844796 ◽

2019 ◽

Vol 5 (2) ◽

pp. 205521731984479 ◽

Cited By ~ 2

Author(s):

Martin Hardmeier ◽

François Jacques ◽

Philipp Albrecht ◽

Habib Bousleiman ◽

Christian Schindler ◽

...

Keyword(s):

Multiple Sclerosis ◽

Clinical Trials ◽

Evoked Potentials ◽

Minimal Detectable Change ◽

Detectable Change ◽

Critical Difference ◽

Cross Sectional ◽

Sensory Evoked Potentials ◽

Sensory Evoked ◽

Multiple Sclerosis Patients

Background Motor and sensory evoked potentials (EP) are potential candidate biomarkers for clinical trials in multiple sclerosis. Objective To determine test -retest reliability of motor EP (MEP) and sensory EP (SEP) and associated EP-scores in patients with multiple sclerosis. Methods In three centres, 16 relapsing and five progressive multiple sclerosis patients had MEPs and SEPs 1–29 days apart. Five neurophysiologists independently marked latencies by central reading. By variance component analysis, we estimated the critical difference (absolute reliability) for cross-sectional group comparison, comparison of longitudinal group changes, within-subject minimal detectable change and defined within-subject improvement. Results Cortical SEP responses and cortico-muscular MEP latencies were more reliable than central conduction times. For comparison of 20 subjects per arm, cross-sectional group difference ranged from 0.7 to 3.9 ms and 1.1 to 1.7, group difference in longitudinal changes from 0.4 to 1.8 ms and 0.36 to 0.62, within-subject minimal detectable change from 1.2 to 5.8 ms and 1.2 to 2.0, within-subject improvement from 0.8 to 3.8ms and 0.8 to 1.3, for single EP modalities and EP scores, respectively. Conclusions Multicentre EP assessment with central EP reading is feasible and reliable. The critical difference is reasonably low to detect significant group changes and to define responders. The results support the concept of using EP and EP-scores as candidate response biomarkers for quantification of disease progression and for studying remyelination in multiple sclerosis.

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