The Ultrastructure of the Human Bronchial Submucosa
Up until now the only clinical interest in the human submucosa has centered around the hypertrophy of the mucous secreting glands in patients with chronic cough and sputum. Besides this function, the submucosa, which is a loose connective tissue, provides mechanical and functional support for the mucosa and also contains numerous cells whose contribution to bronchial physiology is not yet fully understood.The mucosa is separated from the submucosa by the basement membrane, which is a thin, amorphous sheet between these two tissues. Auerbach has reported budding of the mucosal cells into the basement membrane in cigarette smoking dogs; a similar finding is shown in Figure 1 in a human cigarette smoker. Immediately beneath the basement membrane is a collection of reticular fibers which vary from being a thin layer of light density to a dense, thick layer of fibers. The reticular fibers are smaller, shorter and thinner than collagen fibers, and always single.