Prediction of behavior problems in 4-year-olds born prematurely

1990 ◽  
Vol 2 (1) ◽  
pp. 15-30 ◽  
Author(s):  
Susan Goldberg ◽  
Carl Corter ◽  
Mirek Lojkasek ◽  
Klaus Minde
Keyword(s):  
Behavior Problems ◽  
Family Environment ◽  
Low Birthweight ◽  
Very Low Birthweight ◽  
Preliminary Model ◽  
Proposed Model ◽  
Mother Child Relationships ◽  
Teacher Reports ◽  
Mother Attachment

AbstractLongitudinal follow-up data for 69 very low birthweight preterm infants were used to assess the influence of four factors (neonatal medical complications, infant temperament, mother-child relationships, and family environment) on mother and teacher reports of behavior problems at 4 years. The proposed model of such influences being tested assumed that (1) the effects of neonatal medical factors would be indirect, and (2) each of the other three factors would show high stability from 1 to 4 years and would have a direct influence on behavior problem outcomes. Neither neonatal medical data nor infant-mother attachment were good predictors of behavior problems at age 4. With these exceptions, teacher report of behavior problems was predicted in a fashion consistent with the preliminary model. However, mother reports of behavior problems was predicted only by prior mother reports of child temperament. Discussion focuses on reasons for discrepancies in these pathways of influence.

Thromboelastographic profiles of healthy very low birthweight infants serially during their first month

2019 ◽  
Vol 105 (4) ◽  
pp. 412-418 ◽  
Author(s):  
Genny Raffaeli ◽  
Armando Tripodi ◽  
Giacomo Cavallaro ◽  
Valeria Cortesi ◽  
Erica Scalambrino ◽  
...  
Keyword(s):  
Neonatal Intensive Care ◽  
Low Birthweight ◽  
Maximum Amplitude ◽  
Very Low Birthweight ◽  
Term Infants ◽  
Term Neonates ◽  
Outcomes Measures ◽  
Very Low Birthweight Infants ◽  
Α Angle

ObjectiveWe determined thromboelastographic (TEG) profiles of healthy very low birthweight infants (VLBWIs) of the day of birth and at set intervals during their first month.DesignProspective observational study with blinded clinical and laboratory follow-up.SettingLevel III neonatal intensive care unit (June 2015 to June 2018).PatientsConsecutive qualifying VLBWIs were enrolled at birth and followed up for 30 days.Interventions and main outcomes measuresLaboratory (citrated-native TEG, prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen, blood count) and clinical variables were retrieved at birth, 3rd–5th, 10th and 30th day of life. Blood samples temporally related to events with a potential hemostatic impact (sepsis, bleeding, platelets/plasma transfusions, ibuprofen/indomethacin administration) were excluded from analysis.ResultsWe enrolled 201 VLBWIs and 72 full-term neonates. Sixty-seven of the healthy VLBWIs completed the 30-day follow-up. 541 TEG traces were analysed.On day 1, the median (minimum–maximum) TEG values were as follows: reaction time (R), 8.2 min (1–21.8); kinetics (K), 2.8 min (0.8–16); α angle, 51° (14.2–80.6); maximum amplitude (MA), 54.9 mm (23.9–76.8). PT and APTT were 15.9 s (11.7–51.2) and 59 s (37.8–97.5), respectively. The above parameters suggest minor hypocoagulability compared with term infants. On day 30, the median (minimum–maximum) R was 5 (1–16.9), K 1 (0.8–4.1), α 74.7 (41.1–86.7) and MA 70.2 (35.8–79.7). PT and APTT were 12.1 (10.4–16.6) and 38.8 (29.6–51.4), respectively. Those parameters are consistent with a relatively hypercoagulable phenotype, compared with term infants.ConclusionsHealthy VLBWIs have a prolonged PT and APTT, but their TEG profiles suggest a relatively balanced hemostatic system, with slight hypocoagulability initially (compared with term neonates), gradually evolving to a somewhat more procoagulant phenotype over the first month.

scholarly journals LONG TERM FOLLOW-UP IN VERY LOW BIRTHWEIGHT (VLBW) ONEONATES RRHAGE. NEONATES WITH PARAVENTRICULAR INTRAVENTRICULAR HEMORRHAGE

1984 ◽  
Vol 18 ◽  
pp. 352A-352A
Author(s):  
J G Urrutia ◽  
T Mathew ◽  
E Brookfield ◽  
M Satish ◽  
S McQuiston ◽  
...  
Keyword(s):  
Intraventricular Hemorrhage ◽  
Low Birthweight ◽  
Very Low Birthweight ◽  
Long Term Follow Up

Vancomycin-induced ototoxicity in very-low-birthweight infants

2020 ◽  
Author(s):  
Janina Marissen ◽  
Ingmar Fortmann ◽  
Alexander Humberg ◽  
Tanja K Rausch ◽  
Arne Simon ◽  
...  
Keyword(s):  
Low Birthweight ◽  
Multivariable Logistic Regression Analysis ◽  
Very Low Birthweight ◽  
Large Cohort Study ◽  
Hearing Test ◽  
Very Low Birthweight Infants ◽  
Ototoxic Drugs ◽  
Dose Dependent

Abstract Background Vancomycin is an extensively used anti-infective drug in neonatal ICUs. However, exposure–toxicity relationships have not been clearly defined. Objectives To evaluate the risk profile for hearing deficits in vancomycin-exposed very-low-birthweight infants (VLBWI). Methods In a large cohort study of the German Neonatal Network (GNN; n = 16 967 VLBWI) we assessed the association of vancomycin treatment and pathological hearing tests at discharge and at 5 year follow-up. We performed audits on vancomycin exposure, drug levels, dose adjustments and exposure to other ototoxic drugs in a subgroup of 1042 vancomycin-treated VLBWI. Results In the GNN cohort, 28% (n = 4739) were exposed to IV vancomycin therapy. In multivariable logistic regression analysis, vancomycin exposure proved to be independently associated with pathological hearing test at discharge (OR 1.18, 95% CI 1.03–1.34, P = 0.016). Among vancomycin-treated infants, a cumulative vancomycin dose above the upper quartile (>314 mg/kg bodyweight) was associated with pathological hearing test at discharge (OR 2.1, 95% CI 1.21–3.64, P = 0.009), whereas a vancomycin cumulative dose below the upper quartile was associated with a reduced risk of pathological tone audiometry results at 5 years of age (OR 0.29, 95% CI 0.1–0.8, P = 0.02, n = 147). Conclusions Vancomycin exposure in VLBWI is associated with an increased, dose-dependent risk of pathological hearing test results at discharge and at 5 years of age. Prospective studies on long-term hearing impairment are needed.

scholarly journals Nutritional supplementation and growth after hospital discharge in very low birthweight newborns: Randomized controlled trial / Suplementação nutricional e crescimento de recém-nascidos de muito baixo peso após alta hospitalar: Ensaio clínico randomizado

2021 ◽  
Vol 7 (10) ◽  
pp. 101149-101162
Author(s):  
Fernando Lamy Filho ◽  
Eremita Val Rafael ◽  
Roxana Desterro E Silva Da Cunha ◽  
Alcione Miranda Dos Santos ◽  
Zeni Carvalho Lamy ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Weight Gain ◽  
Preterm Infants ◽  
Gestational Age ◽  
Low Birthweight ◽  
Controlled Trial ◽  
Intervention Group ◽  
Very Low Birthweight ◽  
Randomized Controlled

Background Evidence is insufficient to show whether fortification has any effect on growth in preterm infants after discharge. Objective to verify whether VLBW preterm infants who are supplemented with multicomponent present greater anthropometric measurements than those not supplemented. Study Design Parallel randomized controlled trial. A computer-generated random number table was used to allocate the participants. Participants Preterm infants discharged from the NICU of a University Hospital from northeast, Brazil, weighing less than 1,500 g exclusively breastfed at discharge and followed up until they reached 6 months corrected gestational age.  Intervention intervention group received Nestlé® PreNan® formula, fractionated in 2 g of powder, mixed with the mother's milk twice a day. Control group was exclusively breastfed. Follow-up was conducted until the infants reached 6 months corrected gestational age (CGA). Outcomes Growth of the anthropometrics parameters weight, head circumference (HC) and lenth with 6 months of corrected age.  Mixed effects model for longitudinal data was used. Interaction according to sex was detected and ajusted. Results Weight gain was significantly higher in the intervention group. This effect was verified only for males (p = 0.001). No statistically significant association was observed between the intervention and the head circumference or length (p = 0.211; 0.597). The weaning rate at the end of follow-up was similar in both groups. Conclusions Breastmilk supplementation may improve the weight gain of very low birthweight preterm infants up to six months corrected gestational age. This effect differed by sex and was considered significant only for males.

Allergic manifestations in very low-birthweight infants: a 6-year follow-up

2007 ◽  
Vol 92 ◽  
pp. 44-47
Author(s):  
M Agosti ◽  
C Vegni ◽  
S Gangi ◽  
V Benedetti ◽  
A Marini
Keyword(s):  
Low Birthweight ◽  
Very Low Birthweight ◽  
Very Low Birthweight Infants ◽  
Allergic Manifestations
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