The bone morphogenetic protein system and the regulation of ovarian follicle development in mammals

Zygote ◽  
2015 ◽  
Vol 24 (1) ◽  
pp. 1-17 ◽  
Author(s):  
Rodrigo O.D.S. Rossi ◽  
José J.N. Costa ◽  
Anderson W.B. Silva ◽  
Márcia V.A. Saraiva ◽  
Robert Van den Hurk ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bone Morphogenetic Protein ◽  
Transforming Growth Factor ◽  
Ovarian Follicle ◽  
Transforming Growth Factor Β ◽  
Type I ◽  
Serine Threonine Kinase ◽  
Ovarian Follicle Development ◽  
Functional Studies ◽  
Morphogenetic Protein

SummaryThe bone morphogenetic protein (BMP) family consists of several growth factor proteins that belong to the transforming growth factor-β (TGF-β) superfamily. BMPs bind to type I and type II serine–threonine kinase receptors, and transduce signals through the Smad signalling pathway. BMPs have been identified in mammalian ovaries, and functional studies have shown that they are involved in the regulation of oogenesis and folliculogenesis. This review summarizes the role of the BMP system during formation, growth and maturation of ovarian follicles in mammals.

Growth/Differentiation Factor-10: A New Member of the Transforming Growth Factor-β Superfamily Related to Bone Morphogenetic Protein-3

1995 ◽  
Vol 12 (2) ◽  
pp. 99-109 ◽  
Author(s):  
Noreen S. Cunningham ◽  
Nancy A. Jenkins ◽  
Debra J. Gilbert ◽  
Neal G. Copeland ◽  
A. Hari Reddi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bone Morphogenetic Protein ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Differentiation Factor ◽  
Morphogenetic Protein
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