scholarly journals 418 - Long-term Effect of Transcranial Direct Current Stimulation (tDCS) in Alzheimer’s

2021 ◽  
Vol 33 (S1) ◽  
pp. 40-41
Author(s):  
Carol Sheei-Meei Wang ◽  
Kuo-Sheng Cheng ◽  
Chia-Hung Tang ◽  
Nien-Tsen Hou ◽  
Pei-Fang Chien ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Long Term Potentiation ◽  
Chi Square ◽  
Double Blind ◽  
Direct Current Stimulation ◽  
Beneficial Effects ◽  
The Right

AbstractIntroduction:To explore and develop effective treatments is crucial for patients with Alzheimer’s dementia (AD). In pathology, the amyloid deposits of AD result in disruption of the balance between long-term potentiation (LTP) and long-term depression (LTD) of neuronal cells and synaptic plasticity. Transcranial direct current stimulation (tDCS) has been proposed to affect long-term synaptic plasticity through LTP and LTD, thereby improving cognitive ability. Although an increasing number of studies have been concluded a positive therapeutic effect on cognition in AD, tDCS studies to date are limited on exploring the duration of its efficacy. In this pilot study, we investigate the effects of tDCS in AD and verify its extending beneficial effects for 3 months follow-up period after the end of stimulation.Method:34 AD participants aged 55-90 years (mean age 75.9 (66-86)) were included in a double-blind, randomized, sham-controlled crossover study. All participants were randomly assigned to receive 10 consecutive daily sessions of active tDCS (or sham) and switched groups 3 months later. The anodal electrode was on the left dorsal lateral prefrontal cortex and the cathodal electrode was on the right supraorbital area. In each active session, we applied a current intensity of 2 mA and an electrode size of 25 cm2 for 30 min in the active group. All subjects received a series of neuropsychological assessments including CDR, MMSE, CASI and WCST at baseline and in 2 weeks, 4 weeks, and 12 weeks post-tDCS (or sham) 10 sessions. Chi-square tests, Wilcoxon signed rank tests and Mann-Whitney U tests were used to assess the differences in participant demographic characteristics and to compare the differences of test scores between groups.Results:The active tDCS group showed significant improvements on CASI total scores from baseline to 2-weeks, 1-month and 3-months after active stimulations, though the improvement declined over time. There are also different presentations in total correct items, conceptual level responses, failure to maintain sets of WCST between active tDCS and sham groups. There is no difference in MMSE, CASI and WCST scores in the sham groups.Conclusion:These results suggest a long term-beneficial effects of tDCS in AD.

scholarly journals 419 - Effect of Transcranial Direct Current Stimulation (tDCS) in Dementia with Lewy Bodies

2021 ◽  
Vol 33 (S1) ◽  
pp. 41-42
Author(s):  
Carol Sheei-Meei Wang ◽  
Kuo-Sheng Cheng ◽  
Chia-Hung Tang ◽  
Nien-Tsen Hou ◽  
Pei-Fang Chien ◽  
...  
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Dementia With Lewy Bodies ◽  
Functional Disability ◽  
Lewy Bodies ◽  
Long Term Potentiation ◽  
Critical Issue ◽  
Double Blind ◽  
Direct Current Stimulation

AbstractIntroduction:Dementia with Lewy Bodies (DLB), this second most common form of degenerative dementia, presents more functional disability, more potentially fatal complication, more impaired quality of life than Alzheimer’s dementia. There is no FDA-proved medication can slow, stop or improve the progression of cognitive declines in DLB. Identifying effective treatments is a critical issue for DLB. In neuropathology, extracelluar α-syn oligomers interfere with the expression of long-term potentiation, and influence memory and learning. Transcranial direct current stimulation (tDCS) has been proposed to affect long-term synaptic plasticity through LTP and LTD, thereby improving cognitive ability. So far, only two researches assess the effect of tDCS in DLB. In this pilot study, we investigate the effects of tDCS in DLB.Method:Using a double-blind, randomized, sham- controlled and crossover trial design, 11 DLB aged 55-90 years (mean age 77.8) were included in the study. DLB diagnostics is according to DSM-5 criteria. The CDR ratings of DLB participants ranged from 0.5 to 2. The active tDCS (or sham) process includes consecutive daily sessions of active tDCS (or sham) for 10 days. The anodal electrode was over the left dorsal lateral prefrontal cortex (DLPFC) and the cathodal electrode on the right supraorbital area. In each session, we applied a current intensity of 2 mA and an electrode size of 25 cm2 for 30 min in the active group. All subjects received a series of neuropsychological tests, which included CDR, MMSE, CASI, NPI and WCST, before and after these treatment sessions. Chi-square tests, Wilcoxon signed rank tests and Mann-Whitney U tests were used to assess the differences in participant demographic characteristics and to compare the differences among groups.Results:On CASI, MMSE, NPI and WCST, there were no statistically significant differences between pre- and post the 10-session course for the active and the sham groups. No side effects reported during or immediately after active tDCS stimulation.Conclusion:These results suggest that left DLPFC anodal, and right deltoid cathodal tDCS, do not improve cognition, behavioral and psychological symptoms in DLB. Larger-scale trials are needed to confirm the effect of tDCS in DLB.

scholarly journals Cathodal Transcranial Direct Current Stimulation of the Occipital cortex in Episodic Migraine: A Randomized Sham-Controlled Crossover Study

2019 ◽  
Vol 9 (1) ◽  
pp. 60 ◽  
Author(s):  
Rechdi Ahdab ◽  
Anthony G. Mansour ◽  
Georges Khazen ◽  
Christelle El-Khoury ◽  
Toni M. Sabbouh ◽  
...  
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Controlled Trial ◽  
Occipital Cortex ◽  
Episodic Migraine ◽  
Migraine Prophylaxis ◽  
Double Blind ◽  
Direct Current Stimulation ◽  
Beneficial Effects ◽  
Cathodal Tdcs

Summary: Three consecutive daily sessions of cathodal transcranial direct current stimulation (tDCS) was sufficient to show a significant decrease in headache duration and intensity as well as tablets consumption, in patients suffering from episodic migraine. Background: Migraine prophylaxis is recommended in patients with frequent and/or intense headaches, but poor tolerability and lack of efficacy of preventive drugs are common in clinical practice. Hence, new prophylactic strategies are needed. Objective: The aim of this study was to evaluate the efficacy of tDCS in terms of migraine prophylaxis. Methods: This was a double blind and sham-controlled trial. Forty-two migraine patients were randomly assigned in a crossover design to receive three consecutive daily sessions of both sham and cathodal tDCS stimulation (2.0 mA, 20 min) over the occipital cortex of the dominant side of the migraine pain (O1/O2). Migraine duration and intensity, number of analgesic tablets, and number of headache-free days (where no headache abortive medications are taken) were recorded one week before and two weeks after treatment. A washout period of one week was allowed before crossing to the other treatment arm. Results: Relative to sham, cathodal stimulation was associated with a significant reduction in the number of headache days, tablets consumption, and pain intensity; and a significant increase in the number of headache-free days. These beneficial effects were sustained over two weeks. No serious side effects were observed, and the procedure was well tolerated. Conclusion: Based on these findings, cathodal tDCS applied to the occipital cortex seems to be an effective and well tolerated alternative to pharmacotherapy in patients with episodic migraine.

scholarly journals The Long-Term Potentiation-Like Effect in the Corticomotor Area after Transcranial Direct Current Stimulation with Motor Imagery

i-Perception ◽  
10.1068/ic921 ◽  
2011 ◽  
Vol 2 (8) ◽  
pp. 921-921
Author(s):  
Eriko Shibata ◽  
Fuminari Kaneko ◽  
Tatsuya Hayami ◽  
Keita Nagahata ◽  
Masaki Katayose
Keyword(s):  
Motor Imagery ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Long Term Potentiation ◽  
Direct Current Stimulation ◽  
Term Potentiation

scholarly journals Prefrontal Transcranial Direct Current Stimulation Globally Improves Learning but Does Not Selectively Potentiate the Benefits of Targeted Memory Reactivation on Awake Memory Consolidation

2021 ◽  
Vol 11 (8) ◽  
pp. 1104
Author(s):  
Médhi Gilson ◽  
Michael A. Nitsche ◽  
Philippe Peigneux
Keyword(s):  
Direct Current ◽  
Memory Consolidation ◽  
Transcranial Direct Current Stimulation ◽  
Specific Effect ◽  
Memory Reactivation ◽  
Direct Current Stimulation ◽  
Beneficial Effects ◽  
Anodal Stimulation ◽  
The Right ◽  
Stimulation Of

Targeted memory reactivation (TMR) and transcranial direct current stimulation (tDCS) can enhance memory consolidation. It is currently unknown whether TMR reinforced by simultaneous tDCS has superior efficacy. In this study, we investigated the complementary effect of TMR and bilateral tDCS on the consolidation of emotionally neutral and negative declarative memories. Participants learned neutral and negative word pairs. Each word pair was presented with an emotionally compatible sound. Following learning, participants spent a 20 min retention interval awake under four possible conditions: (1) TMR alone (i.e., replay of 50% of the associated sounds), (2) TMR combined with anodal stimulation of the left DLPFC, (3) TMR combined with anodal stimulation of the right DLPFC and (4) TMR with sham tDCS. Results evidenced selective memory enhancement for the replayed stimuli in the TMR-only and TMR-sham conditions, which confirms a specific effect of TMR on memory. However, memory was enhanced at higher levels for all learned items (irrespective of TMR) in the TMR-anodal right and TMR-anodal left tDCS conditions, suggesting that the beneficial effects of tDCS overshadow the specific effects of TMR. Emotionally negative memories were not modulated by tDCS hemispheric polarity. We conclude that electrical stimulation of the DLPFC during the post-learning period globally benefits memory consolidation but does not potentiate the specific benefits of TMR.

Dysfunctional long-term potentiation-like plasticity in schizophrenia revealed by transcranial direct current stimulation

2011 ◽  
Vol 224 (1) ◽  
pp. 15-22 ◽  
Author(s):  
Alkomiet Hasan ◽  
Michael A. Nitsche ◽  
Bettina Rein ◽  
Thomas Schneider-Axmann ◽  
Birgit Guse ◽  
...  
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Long Term Potentiation ◽  
Direct Current Stimulation ◽  
Term Potentiation

scholarly journals Prefrontal Transcranial Direct Current Stimulation globally improves learning, but does not selectively potentiate the benefits of Targeted Memory Reactivation on awake memory consolidation

2020 ◽  
Author(s):  
Médhi Gilson ◽  
Michael A. Nitsche ◽  
Philippe Peigneux
Keyword(s):  
Direct Current ◽  
Memory Consolidation ◽  
Transcranial Direct Current Stimulation ◽  
Specific Effect ◽  
Memory Reactivation ◽  
Direct Current Stimulation ◽  
Beneficial Effects ◽  
Anodal Stimulation ◽  
The Right ◽  
Stimulation Of

AbstractTargeted Memory Reactivation (TMR) and transcranial Direct Current Stimulation (tDCS) can enhance memory consolidation. It is currently unknown whether TMR reinforced by simultaneous tDCS has superior efficacy. In this study, we investigated the complementary effect of TMR and bilateral tDCS on the consolidation of emotionally neutral and negative declarative memories. Participants learned neutral and negative word pairs. Each word pair was presented with an emotionally compatible sound. Following learning, participants spent a 20-minutes retention interval awake under 4 possible conditions: (1) TMR alone (i.e. replay of 50% of the associated sounds), (2) TMR combined with anodal stimulation of the left DLPFC, (3) TMR combined with anodal stimulation of the right DLPFC and (4) TMR with sham tDCS. Results evidenced selective memory enhancement for the replayed stimuli in the TMR-only and TMR-sham conditions, which confirms a specific effect of TMR on memory. However, memory was enhanced at higher levels for all learned items (irrespective of TMR) in the TMR-anodal right and TMR-anodal left tDCS conditions, suggesting that the beneficial effects of tDCS overshadow the specific effects of TMR. Emotionally negative memories were not modulated by tDCS hemispheric polarity. We conclude that electrical stimulation of the DLPFC during post-learning period globally benefits memory consolidation, but does not potentiate the specific benefits of TMR.

Cerebellar, but not Motor or Parietal, High-Density Anodal Transcranial Direct Current Stimulation Facilitates Motor Adaptation

2016 ◽  
Vol 22 (9) ◽  
pp. 928-936 ◽  
Author(s):  
Michael Doppelmayr ◽  
Nils Henrik Pixa ◽  
Fabian Steinberg
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Motor Adaptation ◽  
Double Blind Study ◽  
Single Session ◽  
High Definition ◽  
Double Blind ◽  
Direct Current Stimulation ◽  
Anodal Stimulation ◽  
The Right

AbstractObjectives: Although motor adaptation is a highly relevant process for both everyday life as well as rehabilitation many details of this process are still unresolved. To evaluate the contribution of primary motor (M1), parietal and cerebellar areas to motor adaptation processes transcranial direct current stimulation (tDCS) has been applied. We hypothesized that anodal stimulation of the cerebellum and the M1 improves the learning process in mirror drawing, a task involving fine grained and spatially well-organized hand movements. Methods: High definition tDCS (HD-tDCS) allows a focal stimulation to modulate brain processes. In a single-session double-blind study, we compared the effects of different anodal stimulation procedures. The groups received stimulation either at the cerebellum (CER), at right parietal (PAR), or at left M1, and a SHAM group was included. Participants (n=83) had to complete several mirror drawing tasks before, during, and after stimulation. They were instructed to re-trace a line in the shape of a pentagonal star as fast and accurate as possible. Tracing time (seconds) and accuracy (deviation in mm) have been evaluated. Results: The results indicated that cerebellar HD-tDCS can facilitate motor adaptation in a single session. The stimulation at M1 showed only a tendency to increase motor adaptation and these effects were visible only during the first part of the stimulation. Stimulating the right parietal area, relevant for visuospatial processing did not lead to increased performance. Conclusions: Our results suggest that motor adaptation relies to a great extent on cerebellar functions and HD-tDCS can speed up this process. (JINS, 2016, 22, 928–936)

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