Changes in patterns of left ventricular diastolic filling revealed by Doppler echocardiography in infants with ventricular septal defect

1998 ◽  
Vol 8 (1) ◽  
pp. 94-99 ◽  
Author(s):  
Tadahiko Ito ◽  
Kenji Harada ◽  
Masamichi Tamura ◽  
Goro Takada
Keyword(s):  
Pulmonary Hypertension ◽  
Ventricular Septal Defect ◽  
Septal Defect ◽  
Volume Overload ◽  
Left Ventricular ◽  
Diastolic Filling ◽  
Filling Fraction ◽  
Ventricular Compliance ◽  
Left Ventricular Diastolic Filling ◽  
Deceleration Time

AbstractTo evaluate left ventricular diastolic filling in infants with ventricular septal defect, which has yet to be documented, we measured various Doppler echocardiographic indexes from transmitral flow in the following groups: 10 infants with ventricular septal defect without pulmonary hypertension; 10 infants with ventricular septal defect with pulmonary hypertension; and 9 normal infants to serve as controls. The peak A, total velocity time integral, E area, and A area in patients without pulmonary hypertension were all significantly larger than those in controls. The peak ratio E/A, and 1/3 filling fraction, in patients without pulmonary hypertension were significantly lower than in controls. The peak A, A area, and deceleration time in patients with pulmonary hypertension were significantly larger than in patients without pulmonary hypertension and controls. The peak E/A, area E/A, and 1/3 filling fraction in patients with pulmonary hypertension were significantly lower than in those without pulmonary hypertension and controls. The index of left ventricular mass, as well as the index of end-diastolic left ventricular wall thickness, correlated strongly with peak A, A area, and deceleration time. The ratio between the systolic pulmonary and systemic pressures correlated strongly with peak A, A area, peak E/A, area EtA, and 1/3 filling fraction.These results demonstrated that the patterns of left ventricular filling in infants with ventricular septal defect were different from those in normal infants, and suggested that the abnormal patterns may indicate the insufficiency of adaptation of left ventricle (increase of left ventricular compliance) for volume overload in the presence of a ventricular septal defect..

Effect of exercise on left ventricular diastolic filling in athletes and nonathletes

1983 ◽  
Vol 55 (2) ◽  
pp. 323-328 ◽  
Author(s):  
M. Matsuda ◽  
Y. Sugishita ◽  
S. Koseki ◽  
I. Ito ◽  
T. Akatsuka ◽  
...  
Keyword(s):  
Left Ventricular ◽  
Volume Control ◽  
Diastolic Filling ◽  
Filling Fraction ◽  
Filling Volume ◽  
Control Subjects ◽  
Left Ventricular Dimension ◽  
Ergometer Exercise ◽  
Ventricular Dimension ◽  
Left Ventricular Diastolic Filling

To evaluate the effect of exercise on left ventricular diastolic filling, the following were measured at rest and during exercise in 14 control subjects and 15 athletes, using digitized M-mode echocardiography: the peak early diastolic lengthening rate of the left ventricular dimension and the filling volume and the filling fraction during the first 0.10 s of diastole. During ergometer exercise performed at a level that increased the heart rate to 100 beats/min, there were significant increases in the peak normalized lengthening rate of the left ventricular dimension (control subjects, 4.2 +/- 1.3 vs. 6.1 +/- 1.1 s-1, mean +/- SD, P less than 0.001; athletes, 5.3 +/- 0.9 vs. 7.4 +/- 1.1 s-1, P less than 0.001), filling volume (control subjects, 15 +/- 12 vs. 33 +/- 10 ml, P less than 0.001; athletes, 21 +/- 12 vs. 63 +/- 18 ml, P less than 0.001), and filling fraction (control subjects, 21 +/- 14 vs. 42 +/- 17%, P less than 0.005; athletes, 21 +/- 13 vs. 54 +/- 12%, P less than 0.01). The peak lengthening rate of the left ventricular dimension, the filling volume, and the filling fraction were significantly greater in athletes than in control subjects during exercise (P less than 0.005, P less than 0.001, and P less than 0.05, respectively). Augmented early diastolic filling may be a mechanism to provide adequate filling for the ventricle at high heart rates produced by exercise, especially in athletes.

scholarly journals Abnormal Left Ventricular Diastolic Filling in Chronic Thromboembolic Pulmonary Hypertension

2007 ◽  
Vol 49 (12) ◽  
pp. 1334-1339 ◽  
Author(s):  
Swaminatha V. Gurudevan ◽  
Philip J. Malouf ◽  
William R. Auger ◽  
Thomas J. Waltman ◽  
Michael Madani ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Chronic Thromboembolic Pulmonary Hypertension ◽  
Left Ventricular ◽  
Diastolic Filling ◽  
Thromboembolic Pulmonary Hypertension ◽  
Left Ventricular Diastolic Filling

Cardiovascular events in perimembranous ventricular septal defect with left ventricular volume overload: a French prospective cohort study (FRANCISCO)

2021 ◽  
pp. 1-6
Author(s):  
Lisa Guirgis ◽  
Estibaliz Valdeolmillos ◽  
Guy Vaksmann ◽  
Clément Karsenty ◽  
Ali Houeijeh ◽  
...  
Keyword(s):  
Ventricular Septal Defect ◽  
Septal Defect ◽  
Volume Overload ◽  
Ventricular Volume ◽  
Left Ventricular ◽  
Surgical Closure ◽  
Perimembranous Ventricular Septal Defect ◽  
New Information ◽  
Hypertension In Children

Brief summary The long-term prospective multi-centre nationwide (French) observational study FRANCISCO will provide new information on perimembranous ventricular septal defect with left ventricular overload but no pulmonary hypertension in children older than 1 year. Outcomes will be compared according to treatment strategy (watchful waiting, surgical closure, or percutaneous closure) and anatomic features of the defect. The results are expected to provide additional guidance about the optimal treatment of this specific population, which is unclear at present.

scholarly journals Impact of percutaneous ventricular septal defect closure on left ventricular remodeling and function

2021 ◽  
Vol 73 (1) ◽  
Author(s):  
Amr Abdel Aal ◽  
Housam M. Hassan ◽  
Dina Ezzeldin ◽  
Maiy El Sayed
Keyword(s):  
Ventricular Septal Defect ◽  
Septal Defect ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Volume Overload ◽  
Left Ventricular ◽  
Published Data ◽  
Z Score ◽  
Lv Remodeling ◽  
And Function

Abstract Background Ventricular septal defect (VSD) is the most common congenital heart disease. In patients with large VSD, left side chambers are subjected to volume overload with subsequent chambers dilatation and eccentric left ventricular hypertrophy. Percutaneous closure of VSD has been shown to be an effective method with equal safety and efficacy when compared to surgery. The effect of VSD closure on LV remodeling has been mainly assessed in patients treated with surgery and to date published data remain scarce. Therefore, we aim to evaluate the effect of percutaneous VSD closure on different LV parameters. Results Seventeen patients (median age 6 years (IQR 4.75–8 years), 70.6% females) who underwent percutaneous VSD closure were enrolled in the study. Sixteen patients (94%) had perimembranous VSD, and one patient had muscular VSD. The procedure was successful in all patients with no major complications. Nit Occlud® Lê coil device was implanted in 16 patients (94%), and one patient received Amplatzer PDA duct occlude device. At 6-months follow-up, there was a significant reduction in indexed LV dimensions [LVEDD/BSA (median 46.5 mm/m2 vs. 42.9 mm/m2, p = 0.03), LVESD/BSA (median 31.7 mm/m2 vs. 26.7 mm/m2, p = 0.02)], indexed LV volumes [LVEDV/BSA (median 52.6 ml/m2 vs. 37.3 ml/m2, p = 0.02), LVESV/BSA (median 31.7 ml/m2 vs. 23.3 ml/m2, p = 0.02)] and indexed LV mass (median 62.4 gm/m2 vs. 57.9 ml/m2, p = 0.01). There was a significant reduction in LVEDD Z-score (p = 0.01) and LVESD Z-score (p = 0.04). There was no significant change in LV EF. Conclusions Percutaneous VSD closure is associated with improvement of various LV parameters with consequential favorable LV remodeling and function.

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