Depressed Subjects Have Decreased rCBF Activation During Facial Emotion Recognition

AbstractDepressed subjects have deficits in facialemotion recognition that resemble the deficits found in persons with focal right hemisphere brain damage. To locate the brain regions responsible for this problem, the authors imaged regional cerebral blood flow (rCBF) with H2O15 positron emission tomography in 10 mood-disordered patients, as well as in 10 age- and sex-matched healthy comparison subjects, while the subjects matched photographs for facial emotion or, as a control, facial identity. While matching faces for emotion, mood-disordered subjects had decreased rCBF activation bilaterally in their temporal lobes, as well as in the right insula, compared with healthy comparison subjects. Abnormal function of limbic and paraiimbic regions may partially explain the facial emotion-recognition deficits previously noted in depressed subjects.

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The correlation between fractional amplitude of low-frequency fluctuation-based resting-state functional magnetic resonance imaging and facial emotion recognition ability in patients with first-episode schizophrenia

10.21203/rs.3.rs-919680/v1 ◽

2021 ◽

Author(s):

Qijie Kuang ◽

Yi Liu ◽

Sumiao Zhou ◽

Taiyong Bi ◽

Lin Mi ◽

...

Keyword(s):

Emotion Recognition ◽

Resting State ◽

Meta Analysis ◽

Pearson Correlation ◽

Low Frequency ◽

Brain Regions ◽

Facial Emotion ◽

First Episode ◽

The Right ◽

First Episode Schizophrenia

Abstract Our aim was to analyse the correlation between the fractional amplitude of low-frequency fluctuation (fALFF) and facial emotion recognition (FER) ability in patients with first-episode schizophrenia (FSZ). A total of 28 patients with FSZ and 33 healthy controls (HCs) completed visual search tasks for FER ability. Regions of interest (ROIs) related to facial emotion were obtained from a previous meta-analysis. Pearson correlation analysis was performed to understand the correlation between fALFF and FER ability. Our results indicated that the patients performed worse than the HCs in the accuracy performances of happy FER and fearful FER. The previous meta-analysis results showed that the brain regions related to FER included the bilateral amygdala (AMY)/hippocampus (HIP), right fusiform gyrus (FFG), and right supplementary motor area (SMA). Pearson correlation showed that the fALFF of the right FFG was associated with high-load fearful FER accuracy (r = -0.43, p = 0.022). Multiple regression analysis showed that the fALFF of the right FFG was an independent contributor to fearful FER accuracy. Our study indicates that FER ability is correlated with resting-state intrinsic activity in brain regions related to facial emotion, which may provide a reference for the study of FER in schizophrenia.

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Brain regions involved in verbal or non-verbal aspects of facial emotion recognition

Neuroreport ◽

10.1097/00001756-200008030-00044 ◽

2000 ◽

Vol 11 (11) ◽

pp. 2571-2574 ◽

Cited By ~ 51

Author(s):

Jin Narumoto ◽

Hiroki Yamada ◽

Tetsuya Iidaka ◽

Norihiro Sadato ◽

Kenji Fukui ◽

...

Keyword(s):

Emotion Recognition ◽

Brain Regions ◽

Facial Emotion Recognition ◽

Facial Emotion

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Activation of the Right Inferior Frontal Cortex During Assessment of Facial Emotion

Journal of Neurophysiology ◽

10.1152/jn.1999.82.3.1610 ◽

1999 ◽

Vol 82 (3) ◽

pp. 1610-1614 ◽

Cited By ~ 171

Author(s):

Katsuki Nakamura ◽

Ryuta Kawashima ◽

Kengo Ito ◽

Motoaki Sugiura ◽

Takashi Kato ◽

...

Keyword(s):

Frontal Cortex ◽

Normal Subjects ◽

Brain Regions ◽

Facial Emotion ◽

Facial Stimuli ◽

Inferior Frontal Cortex ◽

Positron Emission ◽

Triangular Area ◽

The Right ◽

Communicative Signals

We measured regional cerebral blood flow (rCBF) using positron emission tomography (PET) to determine which brain regions are involved in the assessment of facial emotion. We asked right-handed normal subjects to assess the signalers’ emotional state based on facial gestures and to assess the facial attractiveness, as well as to discriminate the background color of the facial stimuli, and compared the activity produced by each condition. The right inferior frontal cortex showed significant activation during the assessment of facial emotion in comparison with the other two tests. The activated area was located within a triangular area of the inferior frontal cortex in the right cerebral hemisphere. These results, together with those of previous imaging and clinical studies, suggest that the right inferior frontal cortex processes emotional communicative signals that could be visual or auditory and that there is a hemispheric asymmetry in the inferior frontal cortex in relation to the processing of emotional communicative signals.

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Serotonin 5-HT2 receptor imaging in major depression: focal changes in orbito-insular cortex

The British Journal of Psychiatry ◽

10.1192/bjp.171.5.444 ◽

1997 ◽

Vol 171 (5) ◽

pp. 444-448 ◽

Cited By ~ 137

Author(s):

Françoise Biver ◽

David Wikler ◽

Françoise Lotstra ◽

Philippe Damhaut ◽

Serge Goldman ◽

...

Keyword(s):

Major Depression ◽

Rating Scale ◽

Right Hemisphere ◽

Statistical Parametric Mapping ◽

Insular Cortex ◽

Brain Regions ◽

Receptor Imaging ◽

Depressed Patients ◽

Positron Emission ◽

The Right

BackgroundSerotonin receptors may play an important role in the pathophysiology of affective disorders. We studied type-2 serotonin (5-HT2) receptors in the brain of patients with major depression.MethodUsing positron emission tomography (PET) and the selective radioligand [18F]altanserin, we investigated 5-HT2 receptor distribution in eight drug-free unipolar depressed patients and 22 healthy subjects. Data were analysed using Statistical Parametric Mapping 95.ResultsIn depressed patients, [18F]altanserin uptake was significantly reduced in a region of the right hemisphere including the posterolateral orbitofrontal cortex and the anterior insular cortex. A trend to similar changes was found in the left hemisphere. No correlation was found between the uptake and the Hamilton rating scale score.ConclusionsPathophysiology of depression may involve changes in 5-HT2 receptor in brain regions selectively implicated in mood regulation.

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Beeinträchtigtes Erkennen emotionaler Gesichtsausdrücke durch psychiatrische Patientinnen bei Alexithymie

Zeitschrift für Psychiatrie Psychologie und Psychotherapie ◽

10.1024/1661-4747/a000135 ◽

2013 ◽

Vol 61 (1) ◽

pp. 7-15 ◽

Cited By ~ 1

Author(s):

Daniel Dittrich ◽

Gregor Domes ◽

Susi Loebel ◽

Christoph Berger ◽

Carsten Spitzer ◽

...

Keyword(s):

Emotion Recognition ◽

Emotional Expression ◽

Depression Scale ◽

Facial Emotion Recognition ◽

Facial Emotion ◽

Check List ◽

Psychosomatische Erkrankungen ◽

Psychiatrische Patienten ◽

Symptom Check List ◽

Tas 20

Die vorliegende Studie untersucht die Hypothese eines mit Alexithymie assoziierten Defizits beim Erkennen emotionaler Gesichtsaudrücke an einer klinischen Population. Darüber hinaus werden Hypothesen zur Bedeutung spezifischer Emotionsqualitäten sowie zu Gender-Unterschieden getestet. 68 ambulante und stationäre psychiatrische Patienten (44 Frauen und 24 Männer) wurden mit der Toronto-Alexithymie-Skala (TAS-20), der Montgomery-Åsberg Depression Scale (MADRS), der Symptom-Check-List (SCL-90-R) und der Emotional Expression Multimorph Task (EEMT) untersucht. Als Stimuli des Gesichtererkennungsparadigmas dienten Gesichtsausdrücke von Basisemotionen nach Ekman und Friesen, die zu Sequenzen mit sich graduell steigernder Ausdrucksstärke angeordnet waren. Mittels multipler Regressionsanalyse untersuchten wir die Assoziation von TAS-20 Punktzahl und facial emotion recognition (FER). Während sich für die Gesamtstichprobe und den männlichen Stichprobenteil kein signifikanter Zusammenhang zwischen TAS-20-Punktzahl und FER zeigte, sahen wir im weiblichen Stichprobenteil durch die TAS-20 Punktzahl eine signifikante Prädiktion der Gesamtfehlerzahl (β = .38, t = 2.055, p < 0.05) und den Fehlern im Erkennen der Emotionen Wut und Ekel (Wut: β = .40, t = 2.240, p < 0.05, Ekel: β = .41, t = 2.214, p < 0.05). Für wütende Gesichter betrug die Varianzaufklärung durch die TAS-20-Punktzahl 13.3 %, für angeekelte Gesichter 19.7 %. Kein Zusammenhang bestand zwischen der Zeit, nach der die Probanden die emotionalen Sequenzen stoppten, um ihre Bewertung abzugeben (Antwortlatenz) und Alexithymie. Die Ergebnisse der Arbeit unterstützen das Vorliegen eines mit Alexithymie assoziierten Defizits im Erkennen emotionaler Gesichtsausdrücke bei weiblchen Probanden in einer heterogenen, klinischen Stichprobe. Dieses Defizit könnte die Schwierigkeiten Hochalexithymer im Bereich sozialer Interaktionen zumindest teilweise begründen und so eine Prädisposition für psychische sowie psychosomatische Erkrankungen erklären.

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