Comparison of Neuropsychological Impairment and Vocational Outcomes in Systemic Lupus Erythematosus and Multiple Sclerosis Patients

The ubiquitous human polyomaviruses BK (BKV) and JC (JCV) persist with no adverse effects in immunocompetent individuals. Virus-induced pathogenesis has been linked to virus reactivation during impaired immune conditions. Previous studies have shown a significant difference between the VP1 DNA sequences of JCV obtained from control urine samples and those in progressive multifocal leukoencephalopathy brain samples. This difference could not be detected when comparing normal control urinary JCV DNA with DNA sequences from chronic progressive multiple sclerosis patients. Since BKV and JCV are readily activated in systemic lupus erythematosus (SLE) patients, the presence of specific strains, related to VP1 DNA sequences, was investigated in these patients. VP1 DNA sequences in 100 urine samples from 21 SLE patients and 75 urine samples from 75 healthy pregnant women were analysed and compared to previously reported sequences. The results show that the VP1 sequence profiles of JCV and BKV excreted by SLE patients do not differ significantly from those excreted by immunocompetent individuals. The European JCV subtypes 1A or 1B were represented among all JCV-positive urine specimens, while BKV VP1 sequences showed complete, or almost complete, identity with the MM or JL strains. Different urine samples from the same patient collected over a 1 year period were predominantly stable. BKV VP1 DNA in urine specimens from healthy pregnant women was only detected during the third trimester of their pregnancy. These results argue against SLE-specific JCV and BKV strains and suggest reactivation of the viruses rather than recurrent re-infections of patients with SLE.

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Spinal cord syndromes in patients with systemic lupus erythematosus: differentiating lupus myelitis, neuromyelitis optica, and multiple sclerosis

Lupus ◽

10.1177/0961203319886103 ◽

2019 ◽

Vol 28 (14) ◽

pp. 1656-1662

Author(s):

J N Williams ◽

C B Speyer ◽

D J Kreps ◽

D J Kimbrough ◽

K Costenbader ◽

...

Keyword(s):

Multiple Sclerosis ◽

Systemic Lupus Erythematosus ◽

Spinal Cord ◽

Disease Activity ◽

Neuromyelitis Optica ◽

Lupus Erythematosus ◽

Clinical Laboratory ◽

Activity Index ◽

Disease Activity Index ◽

Systemic Lupus

Objective Non-infectious myelitis in systemic lupus erythematosus (SLE) may be due to SLE myelitis, comorbid multiple sclerosis (MS), or neuromyelitis optica (NMO). We compared characteristics of these three conditions in SLE patients at a large academic institution. Methods We searched for neurologic diagnoses of SLE myelitis, NMO myelitis, and MS myelitis among 2297 patients with at least four 1997 American College of Rheumatology revised criteria for SLE between 2000 and 2015. Each subject was reviewed by a neurologist to confirm the underlying neurologic diagnosis. Demographic, clinical, laboratory, and radiographic data were extracted and compared using Fisher's exact test, analysis of variance, and Wilcoxon rank-sum test. Results Fifteen of the 2297 subjects with SLE (0.7%) met criteria for a spinal cord syndrome: seven had SLE myelitis, three had AQP4 seropositive NMO, and five had MS. The median SLE Disease Activity Index 2000 score at time of neurologic syndrome presentation was higher in SLE myelitis subjects (8, interquartile range (IQR) 7–16) compared with subjects with NMO (6, IQR 0–14) or MS (2, IQR 0–4), p = 0.02. Subjects with SLE myelitis were also more likely to have elevated anti-dsDNA antibodies at presentation (86%) compared with subjects with NMO (33%) or MS (0%), p = 0.03. Conclusion Myelitis occurs rarely among patients with SLE. Compared with subjects with SLE + NMO and subjects with SLE + MS, subjects with SLE myelitis had higher SLE disease activity at presentation.

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Prolactin and prolactin receptor gene polymorphisms in multiple sclerosis and systemic lupus erythematosus

Human Immunology ◽

10.1016/s0198-8859(02)00804-2 ◽

2003 ◽

Vol 64 (2) ◽

pp. 274-284 ◽

Cited By ~ 24

Author(s):

Marta Mellai ◽

Mara Giordano ◽

Sandra D’Alfonso ◽

Maurizio Marchini ◽

Raffaella Scorza ◽

...

Keyword(s):

Multiple Sclerosis ◽

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Gene Polymorphisms ◽

Receptor Gene ◽

Prolactin Receptor ◽

Systemic Lupus ◽

Prolactin Receptor Gene ◽

Receptor Gene Polymorphisms

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THU0026 Genetic Variation Near IRF8 is Associated with Serologic and Cytokine Profiles in Systemic Lupus Erythematosus and Multiple Sclerosis

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2013-eular.554 ◽

2013 ◽

Vol 72 (Suppl 3) ◽

pp. A173.1-A173

Author(s):

B. Chrabot ◽

S. N. Kariuki ◽

M. Zervou ◽

X. Feng ◽

J. Arrington ◽

...

Keyword(s):

Multiple Sclerosis ◽

Systemic Lupus Erythematosus ◽

Genetic Variation ◽

Lupus Erythematosus ◽

Systemic Lupus ◽

Cytokine Profiles

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Optic Neuritis and Myelopathy in Systemic Lupus Erythematosus

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/s0317167100036064 ◽

1986 ◽

Vol 13 (2) ◽

pp. 129-132 ◽

Cited By ~ 48

Author(s):

Stephen Oppenheimer ◽

B.I. Hoffbrand

Keyword(s):

Multiple Sclerosis ◽

Systemic Lupus Erythematosus ◽

Optic Neuritis ◽

Lupus Erythematosus ◽

Anticardiolipin Antibodies ◽

Normal Vision ◽

Central Scotoma ◽

Systemic Lupus ◽

Clinical Presentations ◽

Number Of Patients

ABSTRACT:The optic neuritis of systemic lupus erythematosus (S.L.E.) more frequently results in the persistence of a central scotoma or complete blindness after a single attack than demyelinating optic neuritis, although the initial clinical presentations may be identical. A significant number of patients, however, recover normal vision. Optic neuritis may be the presenting symptom of S.L.E. and as myelopathy may also occur in the course of the disease, confusion with multiple sclerosis may result, especially if there are no arthritic, cutaneous nor visceral manifestations. We report a case of lupus optic neuritis associated with anticardiolipin antibodies and a circulating lupus anticoagulant and suggest these may be a marker for vasculitic optic neuritis and play a role in its aetiology.

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