Chemical studies on tobacco smoke. Quantitative analysis of hydrazine in tobacco and cigarette smoke

1974 ◽  
Vol 46 (7) ◽  
pp. 885-889 ◽  
Author(s):  
Yu-Ying. Liu ◽  
Irwin. Schmeltz ◽  
Dietrich. Hoffmann
Keyword(s):  
Quantitative Analysis ◽  
Cigarette Smoke ◽  
Tobacco Smoke ◽  
Chemical Studies

scholarly journals Analysis of α-Tocopherol in Tobacco and Cigarette Smoke

2020 ◽  
Vol 29 (2) ◽  
pp. 57-65
Author(s):  
Serban C. Moldoveanu
Keyword(s):  
Quantitative Analysis ◽  
Vitamin E ◽  
Cigarette Smoke ◽  
Tobacco Smoke ◽  
Dry Weight ◽  
Weight Basis ◽  
Tocopheryl Acetate ◽  
Total Particulate Matter ◽  
Hplc Technique ◽  
Good Agreement

Summaryα-Tocopherol, a type of vitamin E, has been known to be present in tobacco for many years. The compound is an antioxidant protecting cell membranes from oxidants. α-Tocopherol is transferred from tobacco into cigarette smoke, where it is also present. Analysis of α-tocopherol has been reported in a number of studies and in various matrices including tobacco and tobacco smoke. However, no recent publication describes a method for quantitative analysis of tocopherol in tobacco and in cigarette smoke, and many methods reported from previous studies were not published and only presented at conferences or communicated in internal company publications.The goal of this study was to quantitate α-tocopherol and, if present, α-tocopheryl acetate in tobacco and in tobacco smoke. For this analysis, an original HPLC technique was developed and is described in this report. Both UV and MS/MS (MRM mode) were used as detection procedure for the analysis. The results obtained using UV detection were in very good agreement with the results obtained using MS/MS detection. The method has been applied for the analysis of a number of tobaccos, as well as the total particulate matter (TPM) from cigarettes made with the same tobaccos. Depending on tobacco type, the levels of α-tocopherol vary in tobacco between about 200 μg/g up to about 900 μg/g (“dry weight basis”). For ISO type smoking, the levels of α-tocopherol vary in TPM between about 2 μg/mg up to slightly above 4 μg/mg of TPM. For a cigarette generating TPM of about 10 mg/cig, the α-tocopherol is between about 20 μg/cig up to about 40 μg/cig. A relatively good correlation was obtained between the level of α-tocopherol in smoke (ISO type smoking) and the level of the compound in tobacco. α-Tocopheryl acetate was absent in tobacco.

scholarly journals Chemical Studies on Tobacco Smoke: I. The Quantitative Determination of Indoles in Cigarette Smoke

1966 ◽  
Vol 3 (6) ◽  
Author(s):  
D. Hoffmann ◽  
J. Rubin
Keyword(s):  
United States ◽  
Quantitative Determination ◽  
Cigarette Smoke ◽  
Tobacco Smoke ◽  
Chromatographic Separation ◽  
Quantitative Data ◽  
Internal Standard ◽  
Chemical Studies ◽  
Gas Chromatographic Separation

AbstractA method for the quantitative determination of indole and alkylated indoles in cigarette smoke is described. The analysis consists of distributions between n-hexane / methanol-water (4:1); n-hexane / methanol-water (1:2); column chromatography on Florosil and gas chromatographic separation on 20 % Apiezon L at 155°C. Quantitative data are secured by use of C14-labelled indole as internal standard. In the smoke of an 85 mm blended United States cigarette without filter tip were determined 13.9 µg indole, 14.0 µg skatole, 4.2 µg 3-ethylindole, and 0.21 µg 3-n-propylindole. The presence of an admixture of dimethylindoles was tentatively established; their concentration was below 0.03 µg per cigarette

Chemical Studies on Tobacco Smoke. XLVII. On the Quantitative Analysis of Catechols and Their Reduction

1976 ◽  
Vol 9 (10) ◽  
pp. 939-955 ◽  
Author(s):  
Klaus D. Brunnemann ◽  
Herng-Cherng Lee ◽  
Dietrich Hoffmann
Keyword(s):  
Quantitative Analysis ◽  
Tobacco Smoke ◽  
Chemical Studies

Comparison of Oxidative Effects of Electronic Cigarette and Tobacco Smoke Exposure Performed Experimentally

2021 ◽  
pp. 1-7
Author(s):  
Oktay Aslaner
Keyword(s):  
Oxidative Stress ◽  
Cigarette Smoke ◽  
Tobacco Smoke ◽  
Smoke Exposure ◽  
Electronic Cigarette ◽  
Tobacco Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Control Group ◽  
Exposure Group ◽  
Oxidative Effects

<b><i>Objective:</i></b> Cigarette smoking is a life-threatening habit that has rapidly spread in every socioeconomic part of the public worldwide. There exist mechanisms of nicotine delivery available to use in the hope of halting cigarette smoking, and the electronic cigarette (EC) is one of the common methods used for tobacco smoking replacement. This study aimed to investigate experimentally the oxidative effects of tobacco smoke and EC smoke which contain nicotine. <b><i>Method:</i></b> We constructed smoke circuit rooms for exposing the rats to EC or tobacco smoke. Three groups were created, the control group (<i>N</i> = 8); the electronic cigarette group (<i>N</i> = 8), exposure to electronic cigarette smoke for 2 h per day; and the tobacco group (<i>N</i> = 8), exposure to traditional cigarette smoke for 2 h per day. After the first and second week of exposure, blood samples were obtained, and serum oxidative stress index (OSI), paraoxonase 1 (PON1) activity, and prolidase levels were evaluated. <b><i>Results:</i></b> Higher values of OSI and prolidase levels were detected in the first week of EC or tobacco smoke exposure in both study groups (<i>p</i> &#x3c; 0.001) when compared with the control group, and partial decrements were observed in the second week. By contrast, elevated PON1 levels were observed in the second week after EC or tobacco smoke exposure. The highest OSI levels were observed in the tobacco smoke group (<i>p</i> &#x3c; 0.001). The lowest values of PON1 levels were detected in the first week of the electronic cigarette smoke group, and this decremental value was statistically different than normal, the second week of the electronic cigarette smoke group, the first week of the traditional cigarette smoke exposure group, and the second week of the traditional cigarette smoke exposure group values (<i>p</i> &#x3c; 0.000). <b><i>Conclusion:</i></b> Our results indicate that EC smoke induced oxidative stress. Therefore, ECs are potentially risky for human health and can lead to important health problems.

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