Effect of Cholesterol on the Interaction of Cytochrome P450 Substrate Drug Chlorzoxazone with the Phosphatidylcholine Bilayer

The concurrent use of drugs and herbal products is becoming increasingly prevalent over the last decade. Several herbal products have been known to modulate cytochrome P450 (CYP) enzymes and P-glycoprotein (P-gp) which are recognized as representative drug metabolizing enzymes and drug transporter, respectively. Thus, a summary of knowledge on the modulation of CYP and P-gp by commonly used herbs can provide robust fundamentals for optimizing CYP and/or P-gp substrate drug-based therapy. Herein, we review ten popular medicinal and/or dietary herbs as perpetrators of CYP- and P-gp-mediated pharmacokinetic herb-drug interactions. The main focus is placed on previous works on the ability of herbal extracts and their phytochemicals to modulate the expression and function of CYP and P-gp in severalin vitroandin vivoanimal and human systems.

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Quantitative Methods for Prediction of the Effect of Cytochrome P450 Gene Polymorphisms on Substrate Drug Exposure: Authors’ Reply

Clinical Pharmacokinetics ◽

10.1007/s40262-014-0220-8 ◽

2014 ◽

Vol 54 (3) ◽

pp. 321-321

Author(s):

Jonatan D. Lindh ◽

Ming Chang ◽

Gunnel Tybring ◽

Marja-Liisa Dahl

Keyword(s):

Cytochrome P450 ◽

Gene Polymorphisms ◽

Quantitative Methods ◽

Drug Exposure ◽

Cytochrome P450 Gene ◽

P450 Gene ◽

Substrate Drug

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Quantitative Methods for Prediction of the Effect of Cytochrome P450 Gene Polymorphisms on Substrate Drug Exposure

Clinical Pharmacokinetics ◽

10.1007/s40262-014-0217-3 ◽

2015 ◽

Vol 54 (3) ◽

pp. 319-320

Author(s):

Sylvain Goutelle ◽

Michel Tod

Keyword(s):

Cytochrome P450 ◽

Gene Polymorphisms ◽

Quantitative Methods ◽

Drug Exposure ◽

Cytochrome P450 Gene ◽

P450 Gene ◽

Substrate Drug

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Molecular evolution of a cytochrome P450 for the synthesis of potential antidepressant (2R,6R)-hydroxynorketamine

Chemical Communications ◽

10.1039/d0cc06729f ◽

2021 ◽

Author(s):

Ansgar Bokel ◽

Michael C. Hutter ◽

Vlada B. Urlacher

Keyword(s):

Cytochrome P450 ◽

Molecular Evolution ◽

Cytochrome P450 Monooxygenase ◽

P450 Monooxygenase ◽

Effective Synthesis

Engineered cytochrome P450 monooxygenase CYP154E1 enables the effective synthesis of the potential antidepressant (2R,6R)-hydroxynorketamine via N-demethylation and regio- and stereoselective hydroxylation of (R)-ketamine.

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