Additive Mediated Syn-Anti Conformational Tuning at Nucleation to Capture Elusive Polymorphs: Remarkable Role of Extended π-Stacking Interactions in Driving the Self-Assembly

The self-assembly of an elastin-inspired triblock peptide into nanospheres highlights the important role of conformational flexibility and π–π stacking.

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Toward the Self-Assembly of Metal−Organic Nanotubes Using Metal−Metal and π-Stacking Interactions: Bis(pyridylethynyl) Silver(I) Metallo-macrocycles and Coordination Polymers

Inorganic Chemistry ◽

10.1021/ic1020059 ◽

2011 ◽

Vol 50 (3) ◽

pp. 1123-1134 ◽

Cited By ~ 51

Author(s):

Kelly J. Kilpin ◽

Martin L. Gower ◽

Shane G. Telfer ◽

Geoffrey B. Jameson ◽

James D. Crowley

Keyword(s):

Coordination Polymers ◽

Self Assembly ◽

The Self ◽

Stacking Interactions ◽

Π Stacking ◽

Metal Metal ◽

Metal Organic ◽

Organic Nanotubes

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Supramolecular architectures from the self-assembly of lanthanide coordination compounds containing glycine and phen via hydrogen bonding and π–π stacking interactions

Polyhedron ◽

10.1016/s0277-5387(03)00369-3 ◽

2003 ◽

Vol 22 (18) ◽

pp. 2617-2624 ◽

Cited By ~ 14

Author(s):

Xiang-Jun Zheng ◽

Lin-Pei Jin

Keyword(s):

Hydrogen Bonding ◽

Self Assembly ◽

Coordination Compounds ◽

The Self ◽

Stacking Interactions ◽

Supramolecular Architectures ◽

Π Stacking

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The influence of hydrogen bonding and π–π stacking interactions on the self-assembly properties of C3-symmetrical oligo(p-phenylenevinylene) discs

Organic & Biomolecular Chemistry ◽

10.1039/b517993a ◽

2006 ◽

Vol 4 (8) ◽

pp. 1539 ◽

Cited By ~ 39

Author(s):

Jeroen van Herrikhuyzen ◽

Pascal Jonkheijm ◽

Albertus P. H. J. Schenning ◽

E. W. Meijer

Keyword(s):

Hydrogen Bonding ◽

Self Assembly ◽

The Self ◽

Stacking Interactions ◽

Π Stacking

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A Nanoporous Supramolecular Metal–Organic Framework Based on a Nucleotide: Interplay of the π···π Interactions Directing Assembly and Geometric Matching of Aromatic Tails

Molecules ◽

10.3390/molecules26154594 ◽

2021 ◽

Vol 26 (15) ◽

pp. 4594

Author(s):

Rosaria Bruno ◽

Teresa Mastropietro ◽

Giovanni De Munno ◽

Donatella Armentano

Keyword(s):

Self Assembly ◽

Active Sites ◽

Metal Organic Framework ◽

Building Blocks ◽

The Self ◽

Stacking Interactions ◽

Π Stacking ◽

Geometric Matching ◽

Metal Organic ◽

Organic Framework

Self-assembly is the most powerful force for creating ordered supramolecular architectures from simple components under mild conditions. π···π stacking interactions have been widely explored in modern supramolecular chemistry as an attractive reversible noncovalent tool for the nondestructive fabrication of materials for different applications. Here, we report on the self-assembly of cytidine 5’-monophosphate (CMP) nucleotide and copper metal ions for the preparation of a rare nanoporous supramolecular metal-organic framework in water. π···π stacking interactions involving the aromatic groups of the ancillary 2,2’-bipyridine (bipy) ligands drive the self-assemblies of hexameric pseudo-amphiphilic [Cu6(bipy)6(CMP)2(µ-O)Br4]2+ units. Owing to the supramolecular geometric matching between the aromatic tails, a nanoporous crystalline phase with hydrophobic and hydrophilic chiral pores of 1.2 and 0.8 nanometers, respectively, was successfully synthesized. The encoded chiral information, contained on the enantiopure building blocks, is transferred to the final supramolecular structure, assembled in the very unusual topology 8T6. These kinds of materials, owing to chiral channels with chiral active sites from ribose moieties, where the enantioselective recognition can occur, are, in principle, good candidates to carry out efficient separation of enantiomers, better than traditional inorganic and organic porous materials.

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Evidence of π-stacking interactions in the self-assembly of hIAPP22-29

Proteins Structure Function and Bioinformatics ◽

10.1002/prot.24229 ◽

2013 ◽

Vol 81 (4) ◽

pp. 690-703 ◽

Cited By ~ 31

Author(s):

Adam A. Profit ◽

Valentina Felsen ◽

Justina Chinwong ◽

Elmer-Rico E. Mojica ◽

Ruel Z. B. Desamero

Keyword(s):

Self Assembly ◽

The Self ◽

Stacking Interactions ◽

Π Stacking

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Directive Effect of Chain Length in Modulating Peptide Nano-assemblies

Protein and Peptide Letters ◽

10.2174/0929866527666200224114627 ◽

2020 ◽

Vol 27 (9) ◽

pp. 923-929

Author(s):

Gaurav Pandey ◽

Prem Prakash Das ◽

Vibin Ramakrishnan

Keyword(s):

Electron Microscopy ◽

Amino Acids ◽

Light Scattering ◽

Chain Length ◽

Self Assembly ◽

The Self ◽

Ionic Charge ◽

Self Assembling ◽

Biophysical Techniques

Background: RADA-4 (Ac-RADARADARADARADA-NH2) is the most extensively studied and marketed self-assembling peptide, forming hydrogel, used to create defined threedimensional microenvironments for cell culture applications. Objectives: In this work, we use various biophysical techniques to investigate the length dependency of RADA aggregation and assembly. Methods: We synthesized a series of RADA-N peptides, N ranging from 1 to 4, resulting in four peptides having 4, 8, 12, and 16 amino acids in their sequence. Through a combination of various biophysical methods including thioflavin T fluorescence assay, static right angle light scattering assay, Dynamic Light Scattering (DLS), electron microscopy, CD, and IR spectroscopy, we have examined the role of chain-length on the self-assembly of RADA peptide. Results: Our observations show that the aggregation of ionic, charge-complementary RADA motifcontaining peptides is length-dependent, with N less than 3 are not forming spontaneous selfassemblies. Conclusion: The six biophysical experiments discussed in this paper validate the significance of chain-length on the epitaxial growth of RADA peptide self-assembly.

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