Metabolic Activation of Atomoxetine Mediated by Cytochrome P450 2D6

2021 ◽  
Vol 34 (9) ◽  
pp. 2135-2144 ◽  
Author(s):  
Yutong You ◽  
Xu Wang ◽  
Kaiqi Ma ◽  
Jiaru Li ◽  
Ying Peng ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Metabolic Activation ◽  
Cytochrome P450 2D6 ◽  
P450 2D6

Probing Small-Molecule Binding to Cytochrome P450 2D6 and 2C9: An In Silico Protocol for Generating Toxicity Alerts

ChemMedChem ◽  
2010 ◽  
Vol 5 (12) ◽  
pp. 2088-2101 ◽  
Author(s):  
Gianluca Rossato ◽  
Beat Ernst ◽  
Martin Smiesko ◽  
Morena Spreafico ◽  
Angelo Vedani
Keyword(s):  
Cytochrome P450 ◽  
Small Molecule ◽  
In Silico ◽  
Cytochrome P450 2D6 ◽  
P450 2D6

From Genotype to Phenotype: Cytochrome P450 2D6-Mediated Drug Clearance in Humans

2017 ◽  
Vol 14 (3) ◽  
pp. 649-657 ◽  
Author(s):  
Jie Gao ◽  
Xin Tian ◽  
Jun Zhou ◽  
Ming-Zhu Cui ◽  
Hai-Feng Zhang ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Clearance ◽  
Cytochrome P450 2D6 ◽  
P450 2D6

Arylacetamide κ opioid receptor agonists with reduced cytochrome P450 2D6 inhibitory activity

2005 ◽  
Vol 15 (10) ◽  
pp. 2647-2652 ◽  
Author(s):  
Bertrand Le Bourdonnec ◽  
Christopher W. Ajello ◽  
Pamela R. Seida ◽  
Roberta G. Susnow ◽  
Joel A. Cassel ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Opioid Receptor ◽  
Inhibitory Activity ◽  
Cytochrome P450 2D6 ◽  
Receptor Agonists ◽  
Opioid Receptor Agonists ◽  
P450 2D6

Identification of cytochrome P450 2D6 and 2C9 substrates and inhibitors by QSAR analysis

2012 ◽  
Vol 20 (6) ◽  
pp. 2042-2053 ◽  
Author(s):  
Svava Ósk Jónsdóttir ◽  
Tine Ringsted ◽  
Nikolai G. Nikolov ◽  
Marianne Dybdahl ◽  
Eva Bay Wedebye ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 2D6 ◽  
Qsar Analysis ◽  
P450 2D6
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