scholarly journals Isoflavones as Ah Receptor Agonists in Colon-Derived Cell Lines: Structure–Activity Relationships

2019 ◽  
Vol 32 (11) ◽  
pp. 2353-2364 ◽  
Author(s):  
Hyejin Park ◽  
Un-Ho Jin ◽  
Asuka A. Orr ◽  
Stephanie P. Echegaray ◽  
Laurie A. Davidson ◽  
...  
Keyword(s):  
Cell Lines ◽  
Ah Receptor ◽  
Structure Activity Relationships ◽  
Receptor Agonists ◽  
Structure Activity

scholarly journals Thiourea and Guanidine Compounds and their Iridium Complexes in Drug-Resistant Cancer Cell Lines: Structure-Activity Relationships and Direct Luminescent Imaging

2019 ◽  
Author(s):  
Samuel J. Thomas ◽  
Barbora Balonova ◽  
Jindrich Cinatl ◽  
Mark Wass ◽  
Christopher Serpell ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Nature Medicine ◽  
Cancer Cell Lines ◽  
Resistance Mechanisms ◽  
New Drugs ◽  
Iridium Complexes ◽  
Safety Issues ◽  
Structure Activity Relationships ◽  
Structure Activity

<p>Thiourea and guanidine units are found in nature, medicine, and materials. Their continued exploration in applications as diverse as cancer therapy, sensors, and electronics means that their toxicity is an important consideration. We have systematically synthesised a set of thiourea compounds and their guanidine analogues, and elucidated structure-activity relationships in terms of cellular toxicity in three ovarian cancer cell lines and their cisplatin-resistant sub-lines. We have been able to use the intrinsic luminescence of iridium complexes to visualise the effect of both structure alteration and cellular resistance mechanisms. These findings provide starting points for the development of new drugs and consideration of safety issues for novel thiourea- and guanidine-based materials.</p>

scholarly journals Synthesis and structure–activity relationships of a series of pyrrole cannabinoid receptor agonists

2003 ◽  
Vol 11 (18) ◽  
pp. 3965-3973 ◽  
Author(s):  
Giorgio Tarzia ◽  
Andrea Duranti ◽  
Andrea Tontini ◽  
Gilberto Spadoni ◽  
Marco Mor ◽  
...  
Keyword(s):  
Cannabinoid Receptor ◽  
Structure Activity Relationships ◽  
Receptor Agonists ◽  
Structure Activity
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