Chlorinated Flame-Retardant Dechlorane 602 Potentiates Type 2 Innate Lymphoid Cells and Exacerbates Airway Inflammation

2020 ◽  
Author(s):  
Pengcheng Zhou ◽  
Ting Zheng ◽  
Yunping Li ◽  
Xin Zhang ◽  
Jinhong Feng ◽  
...  
Keyword(s):  
Flame Retardant ◽  
Airway Inflammation ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells

Follistatin-Like 1 Induces the Activation of Type 2 Innate Lymphoid Cells to Promote Airway Inflammation in Asthma

Inflammation ◽  
2021 ◽  
Author(s):  
Siyuan Huang ◽  
Rong Zeng ◽  
Jing Wang ◽  
Xinrui Qiao ◽  
Shuo Li ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells

scholarly journals Androgen signaling negatively controls group 2 innate lymphoid cells

2017 ◽  
Vol 214 (6) ◽  
pp. 1581-1592 ◽  
Author(s):  
Sophie Laffont ◽  
Eve Blanquart ◽  
Magali Savignac ◽  
Claire Cénac ◽  
Gilles Laverny ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Lung Inflammation ◽  
Inflammatory Responses ◽  
Allergic Airway Inflammation ◽  
Innate Lymphoid Cells ◽  
Protective Role ◽  
Lymphoid Cells ◽  
Peripheral Tissues ◽  
Group 2

Prevalence of asthma is higher in women than in men, but the mechanisms underlying this sex bias are unknown. Group 2 innate lymphoid cells (ILC2s) are key regulators of type 2 inflammatory responses. Here, we show that ILC2 development is greatly influenced by male sex hormones. Male mice have reduced numbers of ILC2 progenitors (ILC2Ps) and mature ILC2s in peripheral tissues compared with females. In consequence, males exhibit reduced susceptibility to allergic airway inflammation in response to environmental allergens and less severe IL-33–driven lung inflammation, correlating with an impaired expansion of lung ILC2s. Importantly, orchiectomy, but not ovariectomy, abolishes the sex differences in ILC2 development and restores IL-33–mediated lung inflammation. ILC2Ps express the androgen receptor (AR), and AR signaling inhibits their differentiation into mature ILC2s. Finally, we show that hematopoietic AR expression limits IL-33–driven lung inflammation through a cell-intrinsic inhibition of ILC2 expansion. Thus, androgens play a crucial protective role in type 2 airway inflammation by negatively regulating ILC2 homeostasis, thereby limiting their capacity to expand locally in response to IL-33.

scholarly journals The Involvement of Type 2 Innate Lymphoid Cells in Airway Inflammation of Asthma

2020 ◽  
Vol 40 (4) ◽  
pp. 188-194
Author(s):  
Ruiming Shi ◽  
Xuhua Bian ◽  
Shuang Feng ◽  
Xiaoxia Yang ◽  
Tao Zhao ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells

scholarly journals MicroRNA-155 is a critical regulator of type 2 innate lymphoid cells and IL-33 signaling in experimental models of allergic airway inflammation

2017 ◽  
Vol 139 (3) ◽  
pp. 1007-1016.e9 ◽  
Author(s):  
Kristina Johansson ◽  
Carina Malmhäll ◽  
Patricia Ramos-Ramírez ◽  
Madeleine Rådinger
Keyword(s):  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Innate Lymphoid Cells ◽  
Experimental Models ◽  
Lymphoid Cells

scholarly journals IRF-7 Is a Critical Regulator of Type 2 Innate Lymphoid Cells in Allergic Airway Inflammation

Cell Reports ◽  
2019 ◽  
Vol 29 (9) ◽  
pp. 2718-2730.e6
Author(s):  
Juan He ◽  
Qiong Yang ◽  
Qiang Xiao ◽  
Aihua Lei ◽  
Xing Li ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells

scholarly journals Type 2 innate lymphoid cells: A novel biomarker of eosinophilic airway inflammation in patients with mild to moderate asthma

2015 ◽  
Vol 109 (11) ◽  
pp. 1391-1396 ◽  
Author(s):  
Tian Liu ◽  
Jinxiang Wu ◽  
Jiping Zhao ◽  
Junfei Wang ◽  
Yuanyuan Zhang ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Moderate Asthma

A pro-inflammatory role of type 2 innate lymphoid cells in murine immune-mediated hepatitis

2015 ◽  
Vol 53 (12) ◽  
Author(s):  
K Karimi ◽  
K Neumann ◽  
J Meiners ◽  
R Voetlause ◽  
W Dammermann ◽  
...  
Keyword(s):  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Immune Mediated
Sign in / Sign up

Export Citation Format

Share Document