Mixing Performance of Planar Oscillatory Flow Reactors with Liquid Solutions and Solid Suspensions

Abstract Oscillatory flow reactors (OFRs) superimpose an oscillatory flow to the net movement through a flow reactor. OFRs have been engineered to enable improved mixing, excellent heat- and mass transfer and good plug flow character under a broad range of operating conditions. Such features render these reactors appealing, since they are suitable for reactions that require long residence times, improved mass transfer (such as in biphasic liquid-liquid systems) or to homogeneously suspend solid particles. Various OFR configurations, offering specific features, have been developed over the past two decades, with significant progress still being made. This review outlines the principles and recent advances in OFR technology and overviews the synthetic applications of OFRs for liquid-liquid and solid-liquid biphasic systems.

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Microfluidic mixing through oscillatory transverse perturbations

Modern Physics Letters B ◽

10.1142/s0217984918400304 ◽

2018 ◽

Vol 32 (12n13) ◽

pp. 1840030 ◽

Cited By ~ 2

Author(s):

J. W. Wu ◽

H. M. Xia ◽

Y. Y. Zhang ◽

P. Zhu

Keyword(s):

Oscillatory Flow ◽

Fluid Mixing ◽

Mixing Enhancement ◽

Constant Flow ◽

Central Channel ◽

Microfluidic Mixing ◽

Mixing Performance ◽

Side Channels ◽

Fluidic Devices ◽

High Fluid

Fluid mixing in miniaturized fluidic devices is a challenging task. In this work, the mixing enhancement through oscillatory transverse perturbations coupling with divergent circular chambers is studied. To simplify the design, an autonomous microfluidic oscillator is used to produce the oscillatory flow. It is then applied to four side-channels that intersect with a central channel of constant flow. The mixing performance is tested at high fluid viscosities of up to 16 cP. Results show that the oscillatory flow can cause strong transverse perturbations which effectively enhance the mixing. The influence of a fluidic capacitor in the central channel is also examined, which at low viscosities can intensify the perturbations and further improve the mixing.

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A Mixing-Based Design Methodology for Continuous Oscillatory Flow Reactors

Chemical Engineering Research and Design ◽

10.1205/026387602753393204 ◽

2002 ◽

Vol 80 (1) ◽

pp. 31-44 ◽

Cited By ~ 59

Author(s):

P. Stonestreet ◽

A.P. Harvey

Keyword(s):

Design Methodology ◽

Oscillatory Flow ◽

Flow Reactors

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Oscillatory Flow Reactors (OFRs) for Continuous Manufacturing and Crystallization

Organic Process Research & Development ◽

10.1021/acs.oprd.5b00225 ◽

2015 ◽

Vol 19 (9) ◽

pp. 1186-1202 ◽

Cited By ~ 100

Author(s):

Thomas McGlone ◽

Naomi E. B. Briggs ◽

Catriona A. Clark ◽

Cameron J. Brown ◽

Jan Sefcik ◽

...

Keyword(s):

Oscillatory Flow ◽

Continuous Manufacturing ◽

Flow Reactors

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Cadmium Sulfide Nanoparticle Synthesis Using Oscillatory Flow Mixing

ASME 2011 International Manufacturing Science and Engineering Conference, Volume 2 ◽

10.1115/msec2011-50276 ◽

2011 ◽

Cited By ~ 2

Author(s):

Barath Palanisamy ◽

Yu-Wei Su ◽

Anna Garrison ◽

Brian Paul ◽

Chih-hung Chang

Keyword(s):

Oscillatory Flow ◽

Flow Behavior ◽

Nanoparticle Synthesis ◽

Inorganic Nanoparticles ◽

Mixing Performance ◽

Flow Mixing ◽

Transmission Electron ◽

Nanoparticle Morphology ◽

Computational Fluid Dynamics Simulations ◽

Dynamics Simulations

Microchannel mixers enable faster mixing times compared with batch stir mixing leading to the promise of higher throughput, better yields and less solvent usage for the solution-phase reactive precipitation of inorganic nanoparticles. However, reliance on diffusive transport for subsecond mixing requires channel dimensions in the tens of micrometers. These channel dimensions make diffusive micromixers vulnerable to clogging. In this paper, an oscillatory flow mixing strategy is explored to increase the contact area between reagents within larger microchannels. Forward and reverse oscillatory signals are designed to pump reactants through a 450 μm high serpentine microchannel to increase advection within the flow. Computational fluid dynamics simulations are performed to provide insight into flow behavior and nanoparticle morphology. Quantification of mixing performance is proposed using mixing quality and particle residence time metrics. Experimental validation is pursued through the reactive precipitation of CdS quantum dots using a reverse oscillatory mixing setup. Transmission electron microscopy provides insights into the particle size distribution and particle crystallinity.

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