Porous Hollow Fiber Membrane-Based Continuous Technique of Polymer Coating on Submicron and Nanoparticles via Antisolvent Crystallization

2015 ◽  
Vol 54 (19) ◽  
pp. 5237-5245 ◽  
Author(s):  
Dengyue Chen ◽  
Dhananjay Singh ◽  
Kamalesh K. Sirkar ◽  
Robert Pfeffer
Keyword(s):  
Hollow Fiber ◽  
Polymer Coating ◽  
Hollow Fiber Membrane ◽  
Fiber Membrane ◽  
Antisolvent Crystallization

A novel hollow fiber membrane-assisted antisolvent crystallization for enhanced mass transfer process control

AIChE Journal ◽  
2018 ◽  
Vol 65 (2) ◽  
pp. 734-744 ◽  
Author(s):  
Linghan Tuo ◽  
Xuehua Ruan ◽  
Wu Xiao ◽  
Xiangcun Li ◽  
Gaohong He ◽  
...  
Keyword(s):  
Mass Transfer ◽  
Process Control ◽  
Transfer Process ◽  
Hollow Fiber ◽  
Hollow Fiber Membrane ◽  
Mass Transfer Process ◽  
Fiber Membrane ◽  
Antisolvent Crystallization

Continuous Synthesis of Polymer-Coated Drug Particles by Porous Hollow Fiber Membrane-Based Antisolvent Crystallization

Langmuir ◽  
2014 ◽  
Vol 31 (1) ◽  
pp. 432-441 ◽  
Author(s):  
Dengyue Chen ◽  
Dhananjay Singh ◽  
Kamalesh K. Sirkar ◽  
Robert Pfeffer
Keyword(s):  
Hollow Fiber ◽  
Hollow Fiber Membrane ◽  
Fiber Membrane ◽  
Continuous Synthesis ◽  
Antisolvent Crystallization

scholarly journals Non-Solvent Influence of Hydrophobic Polymeric Layer Deposition on PVDF Hollow Fiber Membrane for CO2 Gas Absorption

Membranes ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 41
Author(s):  
Abdul Latif Ahmad ◽  
Amir Ikmal Hassan ◽  
Leo Choe Peng
Keyword(s):  
Contact Angle ◽  
Hollow Fiber ◽  
Polymer Coating ◽  
Hollow Fiber Membrane ◽  
Gas Absorption ◽  
Dense Layer ◽  
Fiber Membrane ◽  
Hydrophobic Membrane ◽  
Coating Solution ◽  
Modified Membrane

The implementation of hydrophobicity on membranes is becoming crucial in current membrane technological development, especially in membrane gas absorption (MGA). In order to prevent membrane wetting, a polypropylene (PP) dense layer coating was deposited on a commercial poly(vinylidene fluoride) (PVDF) hollow fiber membrane as a method of enhancing surface hydrophobicity. The weight concentration of PP pellets was varied from 10 mg mL−1 to 40 mg mL−1 and dissolved in xylene. A two-step dip coating was implemented where the PVDF membrane was immersed in a non-solvent followed by a polymer coating solution. The effects of the modified membrane with the non-solvent methyl ethyl ketone (MEK) and without the non–solvent was investigated over all weight concentrations of the coating solution. The SEM investigation found that the modified membrane surface transfiguration formed microspherulites that intensified as PP concentration increased with and without MEK. To understand the coating formation further, the solvent–non-solvent compatibility with the polymer was also discussed in this study. The membrane characterizations on the porosity, the contact angle, and the FTIR spectra were also conducted in determining the polymer coating properties. Hydrophobic membrane was achieved up to 119.85° contact angle and peak porosity of 87.62% using MEK as the non-solvent 40 mg mL−1 PP concentration. The objective of the current manuscript was to test the hydrophobicity and wetting degree of the coating layer. Hence, physical absorption via the membrane contactor using CO2 as the feed gas was carried out. The maximum CO2 flux of 3.33 × 10−4 mol m−2 s−1 was achieved by 25 mg modified membrane at a fixed absorbent flow rate of 100 mL min−1 while 40 mg modified membrane showed better overall flux stability.

Simulation of Oxygen Permeability of Dual-phase Hollow Fiber Membrane

2012 ◽  
Vol 27 (9) ◽  
pp. 951-955
Author(s):  
Chun-Li YANG ◽  
Qi-Ming XU ◽  
Ming GONG ◽  
Wei LIU
Keyword(s):  
Hollow Fiber ◽  
Oxygen Permeability ◽  
Hollow Fiber Membrane ◽  
Dual Phase ◽  
Fiber Membrane

scholarly journals Kinetic Analysis of Lidocaine Elimination by Pig Liver Cells Cultured in 3D Multi-Compartment Hollow Fiber Membrane Network Perfusion Bioreactors

2021 ◽  
Vol 8 (8) ◽  
pp. 104
Author(s):  
Gerardo Catapano ◽  
Juliane K. Unger ◽  
Elisabetta M. Zanetti ◽  
Gionata Fragomeni ◽  
Jörg C. Gerlach
Keyword(s):  
Kinetic Analysis ◽  
Drug Screening ◽  
Hollow Fiber ◽  
Hollow Fiber Membrane ◽  
Liver Cells ◽  
Fiber Membrane ◽  
Bioreactor Design ◽  
Drug Adsorption ◽  
And Performance ◽  
Cells Cultured

Liver cells cultured in 3D bioreactors is an interesting option for temporary extracorporeal liver support in the treatment of acute liver failure and for animal models for preclinical drug screening. Bioreactor capacity to eliminate drugs is generally used for assessing cell metabolic competence in different bioreactors or to scale-up bioreactor design and performance for clinical or preclinical applications. However, drug adsorption and physical transport often disguise the intrinsic drug biotransformation kinetics and cell metabolic state. In this study, we characterized the intrinsic kinetics of lidocaine elimination and adsorption by porcine liver cells cultured in 3D four-compartment hollow fiber membrane network perfusion bioreactors. Models of lidocaine transport and biotransformation were used to extract intrinsic kinetic information from response to lidocaine bolus of bioreactor versus adhesion cultures. Different from 2D adhesion cultures, cells in the bioreactors are organized in liver-like aggregates. Adsorption on bioreactor constituents significantly affected lidocaine elimination and was effectively accounted for in kinetic analysis. Lidocaine elimination and cellular monoethylglicinexylidide biotransformation featured first-order kinetics with near-to-in vivo cell-specific capacity that was retained for times suitable for clinical assist and drug screening. Different from 2D cultures, cells in the 3D bioreactors challenged with lidocaine were exposed to close-to-physiological lidocaine and monoethylglicinexylidide concentration profiles. Kinetic analysis suggests bioreactor technology feasibility for preclinical drug screening and patient assist and that drug adsorption should be accounted for to assess cell state in different cultures and when laboratory bioreactor design and performance is scaled-up to clinical use or toxicological drug screening.

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