Peptide Analogues of VPP and IPP with Improved Glucose Uptake Activity in L6 Myotubes can be Released from Cereal Proteins

2021 ◽  
Author(s):  
Ling Liu ◽  
Jiexia Zheng ◽  
Mengjie Zhou ◽  
Shanshan Li ◽  
Guoqing He ◽  
...  
Keyword(s):  
Glucose Uptake ◽  
L6 Myotubes ◽  
Uptake Activity ◽  
Peptide Analogues ◽  
Cereal Proteins

In vitro glucose uptake activity of Aegles marmelos and Syzygium cumini by activation of Glut-4, PI3 kinase and PPARγ in L6 myotubes

Phytomedicine ◽  
2006 ◽  
Vol 13 (6) ◽  
pp. 434-441 ◽  
Author(s):  
R. Anandharajan ◽  
S. Jaiganesh ◽  
N.P. Shankernarayanan ◽  
R.A. Viswakarma ◽  
A. Balakrishnan
Keyword(s):  
Glucose Uptake ◽  
Pi3 Kinase ◽  
Syzygium Cumini ◽  
Glut 4 ◽  
L6 Myotubes ◽  
Uptake Activity

scholarly journals Effects of Oil Palm (Elais guineensis) Fruit Extracts on Glucose Uptake Activity of Muscle, Adipose and Liver Cells

2015 ◽  
Vol 31 (2) ◽  
pp. 83 ◽  
Author(s):  
S Faez ◽  
H Muhajir ◽  
I Amin ◽  
A Zainah
Keyword(s):  
Glucose Uptake ◽  
Cell Lines ◽  
Liver Cell ◽  
Oil Palm ◽  
Elaeis Guineensis ◽  
Chang Liver Cell ◽  
Insulin Mimetic ◽  
L6 Myotubes ◽  
Uptake Activity ◽  
Chang Liver

The effect of oil palm (Elaeis guineensis) fruit aqueous extract (OPF) on glucose uptake activity of three different cell lines was investigated. The cell lines were incubated with different concentrations of OPF to evaluate the stimulatory effect of OPF towards glucose uptake activity of L6 myotubes, 3T3F442A adipocytes and Chang liver cell line. The glucose uptake activities of all tested cells were enhanced in the presence of OPF extract (basal condition). Nevertheless in combination of OPF extract and 100 nM insulin, the glucose uptake activity was only significantly enhanced in L6 myotubes and 3T3F442A adipocytes cell lines. The extracts enhanced the glucose uptake into cells through either insulin-mimetic or insulin-sensitizing property or combination of these two properties. It can be suggested that the OPF extract exerts its antihyperglycemic action partly by mediated glucose uptake into the glucose-responsive disposal cells, muscle, adipose and liver.

Development of Novel Glitazones as Antidiabetic Agents: Molecular Design, Synthesis, Evaluation of Glucose Uptake Activity and SAR Studies

2020 ◽  
Vol 17 (7) ◽  
pp. 840-849
Author(s):  
Mahendra Gowdru Srinivas ◽  
Prabitha Prabhakaran ◽  
Subhankar Probhat Mandal ◽  
Yuvaraj Sivamani ◽  
Pranesh Guddur ◽  
...  
Keyword(s):  
Glucose Uptake ◽  
Molecular Design ◽  
Docking Studies ◽  
Antidiabetic Activity ◽  
Design Synthesis ◽  
In Silico Docking ◽  
Ppar Γ ◽  
Sar Studies ◽  
Structure Activity ◽  
Uptake Activity

Background: Thiazolidinediones and its bioisostere, namely, rhodanines have become ubiquitous class of heterocyclic compounds in drug design and discovery. In the present study, as part of molecular design, a series of novel glitazones that are feasible to synthesize in our laboratory were subjected to docking studies against PPAR-γ receptor for their selection. Methods and Results: As part of the synthesis of selected twelve glitazones, the core moiety, pyridine incorporated rhodanine was synthesized via dithiocarbamate. Later, a series of glitazones were prepared via Knovenageal condensation. In silico docking studies were performed against PPARγ protein (2PRG). The titled compounds were investigated for their cytotoxic activity against 3T3-L1 cells to identify the cytotoxicity window of the glitazones. Further, within the cytotoxicity window, glitazones were screened for glucose uptake activity against L6 cells to assess their possible antidiabetic activity. Conclusion: Based on the glucose uptake results, structure activity relationships are drawn for the title compounds.

Prenylflavonoids from fruit of Macaranga tanarius promote glucose uptake via AMPK activation in L6 myotubes

2021 ◽  
Author(s):  
Noriyuki Natsume ◽  
Takayuki Yonezawa ◽  
Yukiko Saito ◽  
Je-Tae Woo ◽  
Toshiaki Teruya
Keyword(s):  
Glucose Uptake ◽  
Ampk Activation ◽  
L6 Myotubes ◽  
Macaranga Tanarius

scholarly journals Insulinomimetic Zn(II) Complexes as Evaluated by Both Glucose-Uptake Activity and Inhibition of Free Fatty Acids Release in Isolated Rat Adipocytes

2008 ◽  
Vol 56 (8) ◽  
pp. 1181-1183 ◽  
Author(s):  
Midori Nishide ◽  
Yutaka Yoshikawa ◽  
Eriko U. Yoshikawa ◽  
Kinuyo Matsumoto ◽  
Hiromu Sakurai ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Glucose Uptake ◽  
Rat Adipocytes ◽  
Uptake Activity ◽  
Isolated Rat

scholarly journals Anti-Prediabetic Effect of 6-O-Caffeoylsophorose in Prediabetic Rats and Its Stimulation of Glucose Uptake in L6 Myotubes

2017 ◽  
Vol 23 (3) ◽  
pp. 449-456 ◽  
Author(s):  
Gonzalo Miyagusuku-Cruzado ◽  
Naoki Morishita ◽  
Keiichi Fukui ◽  
Norihiko Terahara ◽  
Toshiro Matsui
Keyword(s):  
Glucose Uptake ◽  
L6 Myotubes ◽  
Stimulation Of

scholarly journals In vitro cytotoxicity and glucose uptake activity of chrysin, a flavone in l6 cell lines

2017 ◽  
Vol 08 (03) ◽  
pp. 15894-15897
Author(s):  
Anitha Saravana Kumar ◽  
◽  
Rajadurai M ◽  
Keyword(s):  
Glucose Uptake ◽  
Cell Lines ◽  
In Vitro Cytotoxicity ◽  
Uptake Activity

Gingerols of Zingiber officinale Enhance Glucose Uptake by Increasing Cell Surface GLUT4 in Cultured L6 Myotubes

Planta Medica ◽  
2012 ◽  
Vol 78 (14) ◽  
pp. 1549-1555 ◽  
Author(s):  
Yiming Li ◽  
Van Tran ◽  
Colin Duke ◽  
Basil Roufogalis
Keyword(s):  
Cell Surface ◽  
Glucose Uptake ◽  
Zingiber Officinale ◽  
L6 Myotubes
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