Experimental Measurement and Thermodynamic Modeling of Capecitabine (an Anticancer Drug) Solubility in Supercritical Carbon Dioxide in a Ternary System: Effect of Different Cosolvents

2020 ◽  
Vol 65 (10) ◽  
pp. 4762-4779
Author(s):  
Nedasadat Saadati Ardestani ◽  
Navid Yeganeh Majd ◽  
Mitra Amani
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Ternary System ◽  
Anticancer Drug ◽  
Thermodynamic Modeling ◽  
Experimental Measurement ◽  
Drug Solubility ◽  
System Effect ◽  
Supercritical Carbon

Solubility of the Ketoconazole (an Antifungal Drug) in Supercritical Carbon Dioxide and Menthol as a Cosolvent (Ternary System): Experimental Data and Empirical Correlations

2021 ◽  
Author(s):  
Gholamhossein Sodeifian ◽  
Seyed Ali Sajadian ◽  
Fariba Razmimanesh ◽  
Seyed Mojtaba Hazaveie
Keyword(s):  
Experimental Data ◽  
Carbon Dioxide ◽  
Binary System ◽  
Supercritical Carbon Dioxide ◽  
Ternary System ◽  
Drug Solubility ◽  
Analysis Method ◽  
Empirical Correlations ◽  
Semiempirical Models ◽  
Supercritical Carbon

Abstract One of the main steps in choosing the drug nanoparticle production processes by supercritical carbon dioxide (SC-CO2) is determining the solubility of the solid solute. For this purpose, the solubility of Ketoconazole (KTZ) in the SC-CO2, binary system, as well as in the SC-CO2-menthol (cosolvent), ternary system, was measured at 308–338 K and 12–30 MPa using the static analysis method. The KTZ solubility in the SC-CO2 ranged between 1.70×10− 6 and 8.02×10− 4, while drug solubility in the SC-CO2 with cosolvent varied from 2.7×10− 5 to 1.96×10− 4. This difference indicated the significant effect of menthol cosolvent on KTZ solubility in the SC-CO2. Moreover, KTZ solubilities in the two systems were correlated by several empirical and semiempirical models. Among them, Sodeifian et al., Bian et al., MST, and Bartle et al. models can more accurately correlate experimental data for the binary system than other used models. Also, the Sodeifian and Sajadian model well fitted the solubility data of the ternary system with AARD,%= 6.45, Radj= 0.995.

scholarly journals Thermodynamic modeling of solid solubility in supercritical carbon dioxide: Comparison between mixing rules

2013 ◽  
Vol 19 (3) ◽  
pp. 389-398 ◽  
Author(s):  
Hadi Baseri ◽  
Ali Haghighi-Asl ◽  
Nader Lotfollahi
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Thermodynamic Modeling ◽  
Pressure Range ◽  
The Other ◽  
Mixing Rules ◽  
Calculation Results ◽  
Temperature And Pressure ◽  
Robinson Equation ◽  
Supercritical Carbon

In this paper, Peng Robinson equation of state is used for thermodynamic modeling of the solubility of various solid components in the supercritical carbon dioxide. Moreover, the effects of three mixing rules of Van der Waals mixing rules, Panagiotopoulos and Reid mixing rules and modified Kwak and Mansoori mixing rules on the accuracy of calculation results were studied. Good correlations between calculated and experimental data were obtained in the wide temperature and pressure range. A comparison between used models shows that modified Kwak and Mansoori mixing rules give better correlations in comparison with the other mixing rules.

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