Design and Synthesis of Indenoisoquinolines Targeting Topoisomerase I and Other Biological Macromolecules for Cancer Chemotherapy

2021 ◽  
Author(s):  
Mark Cushman
Keyword(s):  
Cancer Chemotherapy ◽  
Topoisomerase I ◽  
Biological Macromolecules ◽  
Design And Synthesis

scholarly journals Acute presentation of rheumatoid arthritis following cancer chemotherapy using the topoisomerase I inhibitor irinotecan

2005 ◽  
Vol 44 (7) ◽  
pp. 771-772 ◽  
Author(s):  
Thomas C. Yau ◽  
Kin W. Chu ◽  
Mo Y. Mok ◽  
Raymond H. Liang ◽  
Richard J. Epstein
Keyword(s):  
Rheumatoid Arthritis ◽  
Cancer Chemotherapy ◽  
Topoisomerase I ◽  
Topoisomerase I Inhibitor ◽  
Acute Presentation

Synthesis of Benz[d]indeno[1,2-b]pyran-5,11-diones: Versatile Intermediates for the Design and Synthesis of Topoisomerase I Inhibitors.

ChemInform ◽  
2006 ◽  
Vol 37 (27) ◽  
Author(s):  
Andrew Morrell ◽  
Smitha Antony ◽  
Glenda Kohlhagen ◽  
Yves Pommier ◽  
Mark Cushman
Keyword(s):  
Topoisomerase I ◽  
Design And Synthesis ◽  
Topoisomerase I Inhibitors

Synthesis of benz[d]indeno[1,2-b]pyran-5,11-diones: Versatile intermediates for the design and synthesis of topoisomerase I inhibitors

2006 ◽  
Vol 16 (7) ◽  
pp. 1846-1849 ◽  
Author(s):  
Andrew Morrell ◽  
Smitha Antony ◽  
Glenda Kohlhagen ◽  
Yves Pommier ◽  
Mark Cushman
Keyword(s):  
Topoisomerase I ◽  
Design And Synthesis ◽  
Topoisomerase I Inhibitors

Design and synthesis of a DNA intercalative half-sandwich organoruthenium(ii)–chromone complex: cytotoxicity evaluation and topoisomerase Iα inhibition assay

2019 ◽  
Vol 43 (14) ◽  
pp. 5475-5487 ◽  
Author(s):  
Imtiyaz Yousuf ◽  
Farukh Arjmand ◽  
Sartaj Tabassum ◽  
Musheer Ahmad
Keyword(s):  
Topoisomerase I ◽  
Inhibition Assay ◽  
Topoisomerase I Inhibitor ◽  
Design And Synthesis ◽  
Half Sandwich

A half-sandwich organoruthenium(ii)–chromone complex acts as a potential topoisomerase I inhibitor.

Spontaneous 2′-deoxyguanosine alkylation by a new generation of topoisomerase I inhibitors of the camptothecin family

2016 ◽  
Vol 40 (4) ◽  
pp. 3010-3013 ◽  
Author(s):  
B. Naumczuk ◽  
R. Kawęcki ◽  
J. Sitkowski ◽  
W. Bocian ◽  
E. Bednarek ◽  
...  
Keyword(s):  
Cancer Chemotherapy ◽  
Topoisomerase I ◽  
Physiological Conditions ◽  
Topoisomerase I Inhibitors ◽  
New Generation

7-Ethyl-9-(N-morpholino)methyl-10-hydroxycamptothecin spontaneously binds covalently to 2′-deoxyguanosine under near-physiological conditions. This phenomenon may be important in the application of this type of camptothecin derivative in cancer chemotherapy.

ChemInform Abstract: Design and Synthesis of Lamellarin D Analogues Targeting Topoisomerase I

ChemInform ◽  
2010 ◽  
Vol 41 (11) ◽  
pp. no-no
Author(s):  
Takeshi Ohta ◽  
Tsutomu Fukuda ◽  
Fumito Ishibashi ◽  
Masatomo Iwao
Keyword(s):  
Topoisomerase I ◽  
Design And Synthesis
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