Design, Synthesis, and Biological Evaluation of Novel 2-((2-(4-(Substituted)phenylpiperazin-1-yl)ethyl)amino)-5′-N-ethylcarboxamidoadenosines as Potent and Selective Agonists of the A2A Adenosine Receptor

2015 ◽  
Vol 58 (7) ◽  
pp. 3253-3267 ◽  
Author(s):  
Delia Preti ◽  
Pier Giovanni Baraldi ◽  
Giulia Saponaro ◽  
Romeo Romagnoli ◽  
Mojgan Aghazadeh Tabrizi ◽  
...  
Keyword(s):  
Adenosine Receptor ◽  
Biological Evaluation ◽  
A2a Adenosine Receptor ◽  
Design Synthesis ◽  
Selective Agonists ◽  
Synthesis And Biological Evaluation

Design, synthesis, and biological evaluation of a new class of MT2-selective agonists

RSC Advances ◽  
2014 ◽  
Vol 4 (49) ◽  
pp. 25871-25874 ◽  
Author(s):  
Xuan Zhang ◽  
Zhilong Wang ◽  
Qingqing Huang ◽  
Yu Luo ◽  
Xin Xie ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
New Class ◽  
Selective Agonists ◽  
Synthesis And Biological Evaluation

In this study, we have designed and synthesized a novel class of chiral 2,3-dihydro-1H-indene derivatives as highly selective MT2 agonists.

Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis

2020 ◽  
Vol 188 ◽  
pp. 112006 ◽  
Author(s):  
Massimiliano Runfola ◽  
Simona Sestito ◽  
Lorenza Bellusci ◽  
Valeria La Pietra ◽  
Vincenzo Maria D’Amore ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Toxicity Analysis ◽  
Selective Agonists ◽  
Synthesis And Biological Evaluation

Design, Synthesis and Biological Evaluation of Hybrid Molecules Containing Conjugated Styryl Ketone and α-Bromoacryloyl Moieties

2012 ◽  
Vol 9 (2) ◽  
pp. 140-152 ◽  
Author(s):  
Romeo Romagnoli ◽  
Pier Giovanni Baraldi ◽  
Olga Cruz-Lopez ◽  
Maria Kimatrai Salvador ◽  
Delia Preti ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Hybrid Molecules ◽  
Synthesis And Biological Evaluation
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