Discovery and Evaluation of Clinical Candidate AZD3759, a Potent, Oral Active, Central Nervous System-Penetrant, Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor

2015 ◽  
Vol 58 (20) ◽  
pp. 8200-8215 ◽  
Author(s):  
Qingbei Zeng ◽  
Jiabing Wang ◽  
Ziqiang Cheng ◽  
Kan Chen ◽  
Peter Johnström ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Receptor Tyrosine Kinase ◽  
Kinase Inhibitor ◽  
Growth Factor Receptor ◽  
Epidermal Growth ◽  
Clinical Candidate

scholarly journals Novel approaches against epidermal growth factor receptor tyrosine kinase inhibitor resistance

Oncotarget ◽  
2018 ◽  
Vol 9 (20) ◽  
pp. 15418-15434 ◽  
Author(s):  
Carina Heydt ◽  
Sebastian Michels ◽  
Kenneth S. Thress ◽  
Sven Bergner ◽  
Jürgen Wolf ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Tyrosine Kinase Inhibitor ◽  
Receptor Tyrosine Kinase ◽  
Kinase Inhibitor ◽  
Growth Factor Receptor ◽  
Epidermal Growth ◽  
Novel Approaches ◽  
Inhibitor Resistance
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