Oligoethyleneoxy-Modified 99mTc-Labeled β-Amyloid Imaging Probes with Improved Brain Pharmacokinetics for Single-Photon Emission Computed Tomography

2018 ◽  
Vol 61 (3) ◽  
pp. 1330-1339 ◽  
Author(s):  
Xiaoyang Zhang ◽  
Yaqin Hou ◽  
Cheng Peng ◽  
Chu Wang ◽  
Xiang Wang ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Single Photon ◽  
Photon Emission ◽  
Amyloid Imaging ◽  
Emission Computed Tomography ◽  
Single Photon Emission ◽  
Imaging Probes ◽  
Β Amyloid ◽  
Single Photon Emission Computed ◽  
Photon Emission Computed Tomography

Synthesis and biological evaluation of 123I-labeled pyridyl benzoxazole derivatives: novel β-amyloid imaging probes for single-photon emission computed tomography

RSC Advances ◽  
2015 ◽  
Vol 5 (2) ◽  
pp. 1009-1015 ◽  
Author(s):  
Hiroyuki Watanabe ◽  
Masahiro Ono ◽  
Shimpei Iikuni ◽  
Hiroyuki Kimura ◽  
Yoko Okamoto ◽  
...  
Keyword(s):  
Single Photon ◽  
Photon Emission ◽  
Biological Evaluation ◽  
Emission Computed Tomography ◽  
Single Photon Emission ◽  
Imaging Probes ◽  
Β Amyloid ◽  
Single Photon Emission Computed ◽  
Synthesis And Biological Evaluation ◽  
Photon Emission Computed Tomography

The result in the present study suggested that [123I]9 may be a potential SPECT probe for imaging β-amyloid plaques in the brains of patient with Alzheimer's disease.

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