Synthesis and biological evaluation of 123I-labeled pyridyl benzoxazole derivatives: novel β-amyloid imaging probes for single-photon emission computed tomography

RSC Advances ◽  
2015 ◽  
Vol 5 (2) ◽  
pp. 1009-1015 ◽  
Author(s):  
Hiroyuki Watanabe ◽  
Masahiro Ono ◽  
Shimpei Iikuni ◽  
Hiroyuki Kimura ◽  
Yoko Okamoto ◽  
...  
Keyword(s):  
Single Photon ◽  
Photon Emission ◽  
Biological Evaluation ◽  
Emission Computed Tomography ◽  
Single Photon Emission ◽  
Imaging Probes ◽  
Β Amyloid ◽  
Single Photon Emission Computed ◽  
Synthesis And Biological Evaluation ◽  
Photon Emission Computed Tomography

The result in the present study suggested that [123I]9 may be a potential SPECT probe for imaging β-amyloid plaques in the brains of patient with Alzheimer's disease.

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