Structure-Based Discovery of a Subtype-Selective Inhibitor Targeting a Transient Receptor Potential Vanilloid Channel

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.8b01496 ◽

2019 ◽

Vol 62 (3) ◽

pp. 1373-1384 ◽

Author(s):

Hao Chai ◽

Xi Cheng ◽

Bin Zhou ◽

Lifen Zhao ◽

Xianhua Lin ◽

...

Keyword(s):

Transient Receptor Potential ◽

Receptor Potential ◽

Selective Inhibitor ◽

Transient Receptor Potential Vanilloid ◽

Transient Receptor ◽

Subtype Selective

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Faculty Opinions recommendation of Transient receptor potential vanilloid 1 is required for intrinsic osmoreception in organum vasculosum lamina terminalis neurons and for normal thirst responses to systemic hyperosmolality.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1047186.497222 ◽

2006 ◽

Author(s):

Alastair Ferguson

Keyword(s):

Transient Receptor Potential ◽

Receptor Potential ◽

Transient Receptor Potential Vanilloid ◽

Lamina Terminalis ◽

Organum Vasculosum Lamina Terminalis ◽

Organum Vasculosum ◽

Transient Receptor

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Faculty Opinions recommendation of Transient receptor potential vanilloid 1 is required for intrinsic osmoreception in organum vasculosum lamina terminalis neurons and for normal thirst responses to systemic hyperosmolality.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1047186.497108 ◽

2006 ◽

Author(s):

Bernd Nilius

Keyword(s):

Transient Receptor Potential ◽

Receptor Potential ◽

Transient Receptor Potential Vanilloid ◽

Lamina Terminalis ◽

Organum Vasculosum Lamina Terminalis ◽

Organum Vasculosum ◽

Transient Receptor

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Faculty Opinions recommendation of Somatostatin modulates the transient receptor potential vanilloid 1 (TRPV1) ion channel.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1052995.504951 ◽

2006 ◽

Author(s):

Marcos Milla

Keyword(s):

Ion Channel ◽

Transient Receptor Potential ◽

Receptor Potential ◽

Transient Receptor Potential Vanilloid ◽

Transient Receptor

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Faculty Opinions recommendation of A specific subset of transient receptor potential vanilloid-type channel subunits in Caenorhabditis elegans endocrine cells function as mixed heteromers to promote neurotransmitter release.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1063770.516694 ◽

2007 ◽

Author(s):

Oliver Hobert

Keyword(s):

Caenorhabditis Elegans ◽

Neurotransmitter Release ◽

Endocrine Cells ◽

Transient Receptor Potential ◽

Receptor Potential ◽

Transient Receptor Potential Vanilloid ◽

Specific Subset ◽

Transient Receptor

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Faculty Opinions recommendation of Activation of urothelial transient receptor potential vanilloid 4 by 4alpha-phorbol 12,13-didecanoate contributes to altered bladder reflexes in the rat.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1100237.558108 ◽

2008 ◽

Author(s):

Rodolfo Testa

Keyword(s):

Transient Receptor Potential ◽

Receptor Potential ◽

Transient Receptor Potential Vanilloid ◽

Transient Receptor

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Faculty Opinions recommendation of Design and synthesis of peripherally restricted transient receptor potential vanilloid 1 (TRPV1) antagonists.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1108621.564704 ◽

2008 ◽

Author(s):

Rodolfo Testa

Keyword(s):

Transient Receptor Potential ◽

Receptor Potential ◽

Transient Receptor Potential Vanilloid ◽

Design And Synthesis ◽

Transient Receptor

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Faculty Opinions recommendation of The mechanosensitivity of mouse colon afferent fibers and their sensitization by inflammatory mediators require transient receptor potential vanilloid 1 and acid-sensing ion channel 3.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.7001.464490 ◽

2006 ◽

Author(s):

Gyongyi Horvath

Keyword(s):

Ion Channel ◽

Inflammatory Mediators ◽

Transient Receptor Potential ◽

Receptor Potential ◽

Transient Receptor Potential Vanilloid ◽

Mouse Colon ◽

Afferent Fibers ◽

Transient Receptor

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Faculty Opinions recommendation of Disrupting sensitization of transient receptor potential vanilloid subtype 1 inhibits inflammatory hyperalgesia.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718012518.793477186 ◽

2013 ◽

Author(s):

Arpad Szallasi

Keyword(s):

Transient Receptor Potential ◽

Receptor Potential ◽

Transient Receptor Potential Vanilloid ◽

Inflammatory Hyperalgesia ◽

Transient Receptor

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Faculty Opinions recommendation of Deficient transient receptor potential vanilloid type 4 function contributes to compromised [Ca2+]i homeostasis in human autosomal-dominant polycystic kidney disease cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.732869541.793550550 ◽

2018 ◽

Author(s):

Bellamkonda Kishore ◽

Daria Ilatovskaya

Keyword(s):

Kidney Disease ◽

Polycystic Kidney Disease ◽

Transient Receptor Potential ◽

Autosomal Dominant ◽

Receptor Potential ◽

Transient Receptor Potential Vanilloid ◽

Polycystic Kidney ◽

Autosomal Dominant Polycystic Kidney ◽

Transient Receptor

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Dietary supplementation of transient receptor potential vanilloid-1 channel agonists reduces serum total cholesterol level: a meta-analysis of controlled human trials

Critical Reviews in Food Science and Nutrition ◽

10.1080/10408398.2021.1910138 ◽

2021 ◽

pp. 1-11

Author(s):

Leonardo Kelava ◽

David Nemeth ◽

Peter Hegyi ◽

Patrik Keringer ◽

Dora K. Kovacs ◽

...

Keyword(s):

Total Cholesterol ◽

Cholesterol Level ◽

Transient Receptor Potential ◽

Total Cholesterol Level ◽

Meta Analysis ◽

Dietary Supplementation ◽

Receptor Potential ◽

Transient Receptor Potential Vanilloid ◽

Serum Total Cholesterol Level ◽

Transient Receptor

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