Design, Synthesis, and Properties of Phosphoramidate 2′,5′-Linked Branched RNA: Toward the Rational Design of Inhibitors of the RNA Lariat Debranching Enzyme

Nobuhiro Tago; Adam Katolik; Nathaniel E. Clark; Eric J. Montemayor; Kohji Seio; Mitsuo Sekine; P. John Hart; Masad J. Damha

doi:10.1021/acs.joc.5b01719

Design, Synthesis, and Properties of Phosphoramidate 2′,5′-Linked Branched RNA: Toward the Rational Design of Inhibitors of the RNA Lariat Debranching Enzyme

The Journal of Organic Chemistry ◽

10.1021/acs.joc.5b01719 ◽

2015 ◽

Vol 80 (20) ◽

pp. 10108-10118 ◽

Cited By ~ 4

Author(s):

Nobuhiro Tago ◽

Adam Katolik ◽

Nathaniel E. Clark ◽

Eric J. Montemayor ◽

Kohji Seio ◽

...

Keyword(s):

Rational Design ◽

Design Synthesis ◽

Debranching Enzyme ◽

Branched Rna

Download Full-text

Rational Design, Synthesis and Biological Evaluation of Novel Derivatives Based on in vivo Metabolism of Natural Product β-elemene

Letters in Drug Design & Discovery ◽

10.2174/1570180814666171108093021 ◽

2018 ◽

Vol 15 (8) ◽

pp. 905-912 ◽

Cited By ~ 1

Author(s):

Renren Bai ◽

Xiaokang Jie ◽

Eric Salgado ◽

Jian Sun ◽

Yao Zhu ◽

...

Keyword(s):

Natural Product ◽

Rational Design ◽

Biological Evaluation ◽

In Vivo Metabolism ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

Download Full-text

Effect of the dichloro-substitution on antiproliferative activity of phthalimide-thiazole derivatives. Rational design, synthesis, elastase, caspase 3/7, and EGFR tyrosine kinase activity and molecular modeling study

Bioorganic Chemistry ◽

10.1016/j.bioorg.2021.104819 ◽

2021 ◽

Vol 110 ◽

pp. 104819

Author(s):

Beata Donarska ◽

Marta Świtalska ◽

Wojciech Płaziński ◽

Joanna Wietrzyk ◽

Krzysztof Z. Łączkowski

Keyword(s):

Molecular Modeling ◽

Tyrosine Kinase ◽

Antiproliferative Activity ◽

Rational Design ◽

Caspase 3 ◽

Kinase Activity ◽

Tyrosine Kinase Activity ◽

Thiazole Derivatives ◽

Design Synthesis ◽

Egfr Tyrosine Kinase

Download Full-text

Rational Design, Synthesis, and Evaluation of Tetrahydroxamic Acid Chelators for Stable Complexation of Zirconium(IV)

Chemistry - A European Journal ◽

10.1002/chem.201304115 ◽

2014 ◽

Vol 20 (19) ◽

pp. 5584-5591 ◽

Cited By ~ 46

Author(s):

François Guérard ◽

Yong-Sok Lee ◽

Martin W. Brechbiel

Keyword(s):

Rational Design ◽

Design Synthesis

Download Full-text

Rational Design, Synthesis, and DNA Binding Properties of Novel Sequence-Selective Peptidyl Congeners of Ametantrone

ChemMedChem ◽

10.1002/cmdc.201000106 ◽

2010 ◽

Vol 5 (7) ◽

pp. 1080-1091 ◽

Cited By ~ 11

Author(s):

Alessandra Gianoncelli ◽

Serena Basili ◽

Matteo Scalabrin ◽

Alice Sosic ◽

Stefano Moro ◽

...

Keyword(s):

Dna Binding ◽

Rational Design ◽

Binding Properties ◽

Design Synthesis ◽

Dna Binding Properties

Download Full-text

A rational design, synthesis, characterization, and antihypertensive activities of some new substituted benzimidazoles

Medicinal Chemistry Research ◽

10.1007/s00044-012-0462-7 ◽

2013 ◽

Vol 22 (10) ◽

pp. 4622-4632 ◽

Cited By ~ 13

Author(s):

Anurekha Jain ◽

Rajesh Sharma ◽

S. C. Chaturvedi

Keyword(s):

Rational Design ◽

Design Synthesis

Download Full-text

Azido-iodo-N-benzyl derivatives of threo-methylphenidate (Ritalin, Concerta): Rational design, synthesis, pharmacological evaluation, and dopamine transporter photoaffinity labeling

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2010.11.002 ◽

2011 ◽

Vol 19 (1) ◽

pp. 504-512 ◽

Cited By ~ 9

Author(s):

David J. Lapinsky ◽

Ranganadh Velagaleti ◽

Nageswari Yarravarapu ◽

Yi Liu ◽

Yurong Huang ◽

...

Keyword(s):

Dopamine Transporter ◽

Rational Design ◽

Photoaffinity Labeling ◽

Design Synthesis ◽

Pharmacological Evaluation ◽

Derivatives Of

Download Full-text

3,5-Diaryl-1H-pyrazolo[3,4-b]pyridines as potent tubulin polymerization inhibitors: Rational design, synthesis and biological evaluation

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2018.12.053 ◽

2019 ◽

Vol 168 ◽

pp. 426-435 ◽

Cited By ~ 14

Author(s):

Min'an Zhai ◽

Shiyuan Liu ◽

Meiqi Gao ◽

Long Wang ◽

Jun Sun ◽

...

Keyword(s):

Rational Design ◽

Biological Evaluation ◽

Tubulin Polymerization ◽

Design Synthesis ◽

Tubulin Polymerization Inhibitors ◽

Synthesis And Biological Evaluation

Download Full-text

Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2016.04.034 ◽

2016 ◽

Vol 26 (12) ◽

pp. 2931-2935 ◽

Cited By ~ 28

Author(s):

Zhimin Zhang ◽

Shaohua Hou ◽

Hongli Chen ◽

Ting Ran ◽

Fei Jiang ◽

...

Keyword(s):

Rational Design ◽

Design Synthesis ◽

In Vitro Evaluation ◽

Dual Inhibitors

Download Full-text

ChemInform Abstract: Rational Design, Synthesis, and Serine Protease Inhibitory Activity of a Novel P1-Argininal Derivative Featuring a Conformationally Constrained P2-P3 Bicyclic Lactam Moiety.

ChemInform ◽

10.1002/chin.199725191 ◽

2010 ◽

Vol 28 (25) ◽

pp. no-no

Author(s):

S. Y. TAMURA ◽

E. A. GOLDMAN ◽

T. K. BRUNCK ◽

W. C. RIPKA ◽

J. E. SEMPLE

Keyword(s):

Serine Protease ◽

Inhibitory Activity ◽

Rational Design ◽

Design Synthesis ◽

Conformationally Constrained ◽

Protease Inhibitory Activity

Download Full-text

Rational Design, Synthesis, and Evaluation of Key Analogues of CC-1065 and the Duocarmycins

Journal of the American Chemical Society ◽

10.1021/ja073989z ◽

2007 ◽

Vol 129 (45) ◽

pp. 14092-14099 ◽

Cited By ~ 25

Author(s):

Mark S. Tichenor ◽

Karen S. MacMillan ◽

James S. Stover ◽

Scott E. Wolkenberg ◽

Maria G. Pavani ◽

...

Keyword(s):

Rational Design ◽

Design Synthesis

Download Full-text