Enantioselective Synthesis of Tetrahydroquinolines from 2-Aminochalcones via a Consecutive One-Pot Reaction Catalyzed by Chiral Phosphoric Acid

2018 ◽  
Vol 83 (20) ◽  
pp. 12486-12495 ◽  
Author(s):  
Do Young Park ◽  
So Young Lee ◽  
Jiye Jeon ◽  
Cheol-Hong Cheon
Keyword(s):  
Phosphoric Acid ◽  
Enantioselective Synthesis ◽  
One Pot ◽  
Chiral Phosphoric Acid

scholarly journals Catalytic Enantioselective Synthesis of 4-Amino-1,2,3,4-tetrahydropyridine Derivatives from Intramolecular Nucleophilic Addition Reaction of Tertiary Enamides

Synlett ◽  
2018 ◽  
Vol 30 (04) ◽  
pp. 483-487 ◽  
Author(s):  
Shuo Tong ◽  
Mei-Xiang Wang
Keyword(s):  
Phosphoric Acid ◽  
Asymmetric Catalysis ◽  
Nucleophilic Addition ◽  
Addition Reaction ◽  
Enantioselective Synthesis ◽  
Chiral Phosphoric Acid ◽  
Substrate Engineering ◽  
Nucleophilic Addition Reaction ◽  
Engineering Strategy ◽  
Acid Catalyzed

A general and efficient method for the synthesis of highly enantiopure 4-amino-1,2,3,4-tetradydropyridine derivatives based on chiral phosphoric acid catalyzed intramolecular nucleophilic addition of tertiary enamides to imines has been developed. We have also demonstrated a substrate engineering strategy to significantly improve the enantioselectivity of asymmetric catalysis

Catalytic Asymmetric Substitution Reaction of 3-Substituted 2-Indolylmethanols with 2-Naphthols

Synthesis ◽  
2020 ◽  
Vol 52 (23) ◽  
pp. 3684-3692
Author(s):  
Feng Gao ◽  
Yu-Chen Zhang ◽  
Feng Shi ◽  
Jin-Ping Lan ◽  
Yi-Nan Lu ◽  
...  
Keyword(s):  
Phosphoric Acid ◽  
Substitution Reaction ◽  
Enantioselective Synthesis ◽  
Chiral Phosphoric Acid ◽  
Catalytic Asymmetric ◽  
High Yields

A catalytic asymmetric substitution of 3-substituted 2-indolylmethanols with 2-naphthols has been established under the catalysis of chiral phosphoric acid. By this approach, a series of structurally diversified triarylmethane derivatives were obtained in moderate to high yields with good enantioselectivities (up to 97% yield, 95:5 er). This approach not only enriches the chemistry of 2-indolylmethanol-inolved catalytic asymmetric substitutions, but also provides a useful method for the enantioselective synthesis of chiral triarylmethane derivatives.

An organocatalytic asymmetric Friedel–Crafts reaction of 2-substituted indoles with aldehydes: enantioselective synthesis of α-hydroxyl ketones by low loading of chiral phosphoric acid

2020 ◽  
Vol 56 (16) ◽  
pp. 2499-2502 ◽  
Author(s):  
Xiong-fei Deng ◽  
Ying-wei Wang ◽  
Shi-qi Zhang ◽  
Ling Li ◽  
Guang-xun Li ◽  
...  
Keyword(s):  
Phosphoric Acid ◽  
Carbonyl Compound ◽  
Enantioselective Synthesis ◽  
Chiral Phosphoric Acid

Hydroxyl alkylation of indoles by Friedel–Crafts reaction with a carbonyl compound is a useful strategy.

Highly Diastereo- and Enantioselective Synthesis of Cyclohepta[b ]indoles by Chiral-Phosphoric-Acid-Catalyzed (4+3) Cycloaddition

2018 ◽  
Vol 130 (37) ◽  
pp. 12297-12301 ◽  
Author(s):  
Coralie Gelis ◽  
Guillaume Levitre ◽  
Jérémy Merad ◽  
Pascal Retailleau ◽  
Luc Neuville ◽  
...  
Keyword(s):  
Phosphoric Acid ◽  
Enantioselective Synthesis ◽  
Chiral Phosphoric Acid ◽  
Acid Catalyzed

Hypercrosslinking chiral Brønsted acids into porous organic polymers for efficient heterogeneous asymmetric organosynthesis

2021 ◽  
Author(s):  
Xiaoming Liu ◽  
Yuwei Zhang ◽  
Zhenwei Zhang ◽  
Si Ma ◽  
Ji Jia ◽  
...  
Keyword(s):  
Phosphoric Acid ◽  
Alkylation Reaction ◽  
High Porosity ◽  
One Pot ◽  
Chiral Phosphoric Acid ◽  
Axially Chiral ◽  
Construction Strategy ◽  
Chiral Brønsted Acids ◽  
Hypercrosslinked Polymers ◽  
Excellent Stability

Here, we certificated a construction strategy for directly immobilizing the axially chiral phosphoric acid into hypercrosslinked polymers by one-pot Friedel-Crafts alkylation reaction. They have high porosity, excellent stability and tailorable...

Enantioselective Synthesis of anti-1,2-Oxaborinan-3-enes from Aldehydes and 1,1-Di(boryl)alk-3-enes Using Ruthenium and Chiral Phosphoric Acid Catalysts

2017 ◽  
Vol 139 (31) ◽  
pp. 10903-10908 ◽  
Author(s):  
Tomoya Miura ◽  
Junki Nakahashi ◽  
Wang Zhou ◽  
Yota Shiratori ◽  
Scott G. Stewart ◽  
...  
Keyword(s):  
Phosphoric Acid ◽  
Enantioselective Synthesis ◽  
Acid Catalysts ◽  
Chiral Phosphoric Acid
Sign in / Sign up

Export Citation Format

Share Document