Catalytic Asymmetric Substitution Reaction of 3-Substituted 2-Indolylmethanols with 2-Naphthols
Keyword(s):
A catalytic asymmetric substitution of 3-substituted 2-indolylmethanols with 2-naphthols has been established under the catalysis of chiral phosphoric acid. By this approach, a series of structurally diversified triarylmethane derivatives were obtained in moderate to high yields with good enantioselectivities (up to 97% yield, 95:5 er). This approach not only enriches the chemistry of 2-indolylmethanol-inolved catalytic asymmetric substitutions, but also provides a useful method for the enantioselective synthesis of chiral triarylmethane derivatives.
2020 ◽
Vol 18
(28)
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pp. 5388-5399
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Keyword(s):
2017 ◽
Vol 15
(28)
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pp. 6033-6041
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2018 ◽
Vol 83
(20)
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pp. 12486-12495
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Keyword(s):
2016 ◽
Vol 12
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pp. 1111-1121
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