Solid-State Hydrogen–Deuterium Exchange Mass Spectrometry: Correlation of Deuterium Uptake and Long-Term Stability of Lyophilized Monoclonal Antibody Formulations

Deuterium Uptake ◽

Long Term Stability ◽

Hydrogen Deuterium ◽

Optimizing the Formulation and Lyophilization Process for a Fragment Antigen Binding (Fab) Protein Using Solid-State Hydrogen–Deuterium Exchange Mass Spectrometry (ssHDX-MS)

Molecular Pharmaceutics ◽

10.1021/acs.molpharmaceut.9b00614 ◽

2019 ◽

Vol 16 (11) ◽

pp. 4485-4495 ◽

Cited By ~ 2

Author(s):

Lokesh Kumar ◽

Karthik Balakrishna Chandrababu ◽

Shenbaga Moorthy Balakrishnan ◽

Andrea Allmendinger ◽

Benjamin Walters ◽

...

Keyword(s):

Mass Spectrometry ◽

Solid State ◽

Deuterium Exchange ◽

Antigen Binding ◽

Hydrogen Deuterium ◽

Fragment Antigen Binding

Mapping the Binding Interface in a Noncovalent Size Variant of a Monoclonal Antibody Using Native Mass Spectrometry, Hydrogen–Deuterium Exchange Mass Spectrometry, and Computational Analysis

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2017.06.009 ◽

2017 ◽

Vol 106 (11) ◽

pp. 3222-3229 ◽

Cited By ~ 6

Author(s):

Yuetian Yan ◽

Hui Wei ◽

Sutjano Jusuf ◽

Stanley R. Krystek ◽

Jie Chen ◽

...

Keyword(s):

Mass Spectrometry ◽

Monoclonal Antibody ◽

Computational Analysis ◽

Native Mass Spectrometry ◽

Binding Interface ◽

Size Variant ◽

Hydrogen Deuterium ◽

Effects of drying method and excipient on structure and stability of protein solids using solid-state hydrogen/deuterium exchange mass spectrometry (ssHDX-MS)

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2019.118470 ◽

2019 ◽

Vol 567 ◽

pp. 118470 ◽

Cited By ~ 3

Author(s):

Nathan E. Wilson ◽

Elizabeth M. Topp ◽

Qi Tony Zhou

Keyword(s):

Mass Spectrometry ◽

Solid State ◽

Deuterium Exchange ◽

Drying Method ◽

Structure And Stability ◽

Hydrogen Deuterium ◽

Investigating the Interaction between the Neonatal Fc Receptor and Monoclonal Antibody Variants by Hydrogen/Deuterium Exchange Mass Spectrometry

Molecular & Cellular Proteomics ◽

10.1074/mcp.m114.042044 ◽

2014 ◽

Vol 14 (1) ◽

pp. 148-161 ◽

Cited By ~ 59

Author(s):

Pernille Foged Jensen ◽

Vincent Larraillet ◽

Tilman Schlothauer ◽

Hubert Kettenberger ◽

Maximiliane Hilger ◽

...

Keyword(s):

Mass Spectrometry ◽

Monoclonal Antibody ◽

Fc Receptor ◽

Deuterium Exchange ◽

Neonatal Fc Receptor ◽

Hydrogen Deuterium ◽

Correlating Excipient Effects on Conformational and Storage Stability of an IgG1 Monoclonal Antibody with Local Dynamics as Measured by Hydrogen/Deuterium-Exchange Mass Spectrometry

Journal of Pharmaceutical Sciences ◽

10.1002/jps.23543 ◽

2013 ◽

Vol 102 (7) ◽

pp. 2136-2151 ◽

Cited By ~ 76

Author(s):

Prakash Manikwar ◽

Ranajoy Majumdar ◽

John M. Hickey ◽

Santosh V. Thakkar ◽

Hardeep S. Samra ◽

...

Keyword(s):

Mass Spectrometry ◽

Monoclonal Antibody ◽

Storage Stability ◽

Local Dynamics ◽

Igg1 Monoclonal Antibody ◽

Hydrogen Deuterium ◽

And Storage

Solid-State Hydrogen–Deuterium Exchange Mass Spectrometry (ssHDX-MS) of Lyophilized Poly-d,l-Alanine

Molecular Pharmaceutics ◽

10.1021/acs.molpharmaceut.9b00162 ◽

2019 ◽

Vol 16 (7) ◽

pp. 2935-2946 ◽

Cited By ~ 6

Author(s):

Rajashekar Kammari ◽

Elizabeth M. Topp

Keyword(s):

Mass Spectrometry ◽

Solid State ◽

Deuterium Exchange ◽

Hydrogen Deuterium ◽

Effects of temperature and relative humidity in D2O on solid-state hydrogen deuterium exchange mass spectrometry (ssHDX-MS)

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2021.120263 ◽

2021 ◽

Vol 596 ◽

pp. 120263

Author(s):

Rishabh Tukra ◽

Sam Gardner ◽

Elizabeth M. Topp

Keyword(s):

Mass Spectrometry ◽

Solid State ◽

Relative Humidity ◽

Deuterium Exchange ◽

Hydrogen Deuterium ◽

Effects Of Temperature

Stability of antibody drug conjugate formulations evaluated using solid-state hydrogen-deuterium exchange mass spectrometry

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2021.03.006 ◽

2021 ◽

Author(s):

Eunbi Cho ◽

Brendan M. Mayhugh ◽

Jayasree M. Srinivasan ◽

Gregory A. Sacha ◽

Steven L. Nail ◽

...

Keyword(s):

Mass Spectrometry ◽

Solid State ◽

Deuterium Exchange ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Hydrogen Deuterium ◽

Antibody Drug

Ion Mobility Spectrometry-Hydrogen Deuterium Exchange Mass Spectrometry of Anions: Part 3. Estimating Surface Area Exposure by Deuterium Uptake

Journal of the American Society for Mass Spectrometry ◽

10.1007/s13361-015-1305-9 ◽

2015 ◽

Vol 27 (3) ◽

pp. 462-473 ◽

Cited By ~ 6

Author(s):

Mahdiar Khakinejad ◽

Samaneh Ghassabi Kondalaji ◽

Gregory C. Donohoe ◽

Stephen J. Valentine

Keyword(s):

Mass Spectrometry ◽

Surface Area ◽

Ion Mobility Spectrometry ◽

Ion Mobility ◽

Deuterium Exchange ◽

Deuterium Uptake ◽

Hydrogen Deuterium ◽

Isomerization and Oxidation in the Complementarity-Determining Regions of a Monoclonal Antibody: A Study of the Modification–Structure–Function Correlations by Hydrogen–Deuterium Exchange Mass Spectrometry

Analytical Chemistry ◽

10.1021/acs.analchem.5b02800 ◽

2016 ◽

Vol 88 (4) ◽

pp. 2041-2050 ◽

Cited By ~ 43

Author(s):

Yuetian Yan ◽

Hui Wei ◽

Ya Fu ◽

Sutjano Jusuf ◽

Ming Zeng ◽

...

Keyword(s):

Mass Spectrometry ◽

Monoclonal Antibody ◽

Structure Function ◽

Deuterium Exchange ◽

Hydrogen Deuterium ◽

Complementarity Determining Regions