Single-Chirality Near-Infrared Carbon Nanotube Sub-Cellular Imaging and FRET Probes

Nano Letters ◽  
2021 ◽  
Author(s):  
Rachel Langenbacher ◽  
Januka Budhathoki-Uprety ◽  
Prakrit V. Jena ◽  
Daniel Roxbury ◽  
Jason Streit ◽  
...  
2010 ◽  
Author(s):  
Huan-Yao Lei ◽  
Ching-An Peng ◽  
Ming-Jer Tang ◽  
Harold Szu

Nano Letters ◽  
2014 ◽  
Vol 14 (8) ◽  
pp. 4887-4894 ◽  
Author(s):  
Zachary W. Ulissi ◽  
Fatih Sen ◽  
Xun Gong ◽  
Selda Sen ◽  
Nicole Iverson ◽  
...  

2021 ◽  
Author(s):  
Payam Kelich ◽  
Sanghwa Jeong ◽  
Nicole Navarro ◽  
Jaquesta Adams ◽  
Xiaoqi Sun ◽  
...  

AbstractDNA-wrapped single walled carbon nanotube (SWNT) conjugates have remarkable optical properties leading to their use in biosensing and imaging applications. A critical limitation in the development of DNA-SWNT sensors is the current inability to predict unique DNA sequences that confer a strong analyte-specific optical response to these sensors. Here, near-infrared (nIR) fluorescence response datasets for ~100 DNA-SWNT conjugates, narrowed down by a selective evolution protocol starting from a pool of ~1010 unique DNA-SWNT candidates, are used to train machine learning (ML) models to predict new unique DNA sequences with strong optical response to neurotransmitter serotonin. First, classifier models based on convolutional neural networks (CNN) are trained on sequence features to classify DNA ligands as either high response or low response to serotonin. Second, support vector machine (SVM) regression models are trained to predict relative optical response values for DNA sequences. Finally, we demonstrate with validation experiments that integrating the predictions of ensembles of the highest quality CNN classifiers and SVM regression models leads to the best predictions of both high and low response sequences. With our ML approaches, we discovered five new DNA-SWNT sensors with higher fluorescence intensity response to serotonin than obtained previously. Overall, the explored ML approaches introduce an important new tool to predict useful DNA sequences, which can be used for discovery of new DNA-based sensors and nanobiotechnologies.


RSC Advances ◽  
2015 ◽  
Vol 5 (99) ◽  
pp. 80929-80932 ◽  
Author(s):  
Xiaofang Jia ◽  
Dan Li ◽  
Jing Li ◽  
Erkang Wang

Water-dispersed ultrasmall Ag2S nanoclusters (NCs) are prepared directly in aqueous phase via a facile microwave synthesis. The resultant Ag2S NCs with tunable emission from visible to NIR region are promising biological probes for cellular imaging.


The Analyst ◽  
2021 ◽  
Author(s):  
Jianlin Pu ◽  
Chang Liu ◽  
Bin Wang ◽  
Pei Liu ◽  
Yanzi Jin ◽  
...  

Orange red-emitting CDs were constructed from 2,3-diaminopyridine and successfully used for visual colorimetry and near-infrared cellular imaging.


2019 ◽  
Vol 35 (12) ◽  
pp. 1305-1310
Author(s):  
Hanshu WU ◽  
Xiaojun YANG ◽  
Jinxia MEN ◽  
Huibin ZHANG ◽  
Jinpei ZHOU

2020 ◽  
Vol 44 (19) ◽  
pp. 7740-7748
Author(s):  
Daize Mo ◽  
Li Lin ◽  
Pengjie Chao ◽  
Hanjian Lai ◽  
Qingwen Zhang ◽  
...  

The chlorinated dots based on chlorinated benzo[c][1,2,5]thiadiazole unit possess higher fluorescence quantum yields, larger Stokes shifts, and better photostability than the fluorinated dots.


RSC Advances ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 2258-2267 ◽  
Author(s):  
Yunfan Qiao ◽  
Rushi Zhao ◽  
Min Zhang ◽  
Hongyang Zhang ◽  
Yuerong Wang ◽  
...  

In this paper, we presented a new method for constructing near-infrared fluorescence probes and their applications in detecting glucose and hydrogen peroxide (H2O2).


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