A Simple and Commercially Viable Process for Improved Yields of Metopimazine, a Dopamine D2-Receptor Antagonist

Venumanikanta Karicherla; Kumar Phani; Mohan Reddy Bodireddy; Kumar Babu Prashanth; Madhusudana Rao Gajula; Kumar Pramod

doi:10.1021/acs.oprd.7b00052

A Simple and Commercially Viable Process for Improved Yields of Metopimazine, a Dopamine D2-Receptor Antagonist

Organic Process Research & Development ◽

10.1021/acs.oprd.7b00052 ◽

2017 ◽

Vol 21 (5) ◽

pp. 720-731 ◽

Cited By ~ 6

Author(s):

Venumanikanta Karicherla ◽

Kumar Phani ◽

Mohan Reddy Bodireddy ◽

Kumar Babu Prashanth ◽

Madhusudana Rao Gajula ◽

...

Keyword(s):

Receptor Antagonist ◽

Dopamine D2 Receptor ◽

D2 Receptor ◽

Dopamine D2 ◽

Dopamine D2 Receptor Antagonist

Download Full-text

Effects of haloperidol, a dopamine D2 receptor antagonist, on feather pecking behaviour in laying hens

Applied Animal Behaviour Science ◽

10.1016/j.applanim.2003.11.009 ◽

2004 ◽

Vol 86 (1-2) ◽

pp. 77-91 ◽

Cited By ~ 38

Author(s):

J.B. Kjaer ◽

B.M. Hjarvard ◽

K.H. Jensen ◽

J. Hansen-Møller ◽

O. Naesbye Larsen

Keyword(s):

Receptor Antagonist ◽

Laying Hens ◽

Dopamine D2 Receptor ◽

D2 Receptor ◽

Feather Pecking ◽

Dopamine D2 ◽

Dopamine D2 Receptor Antagonist

Download Full-text

Open field and freezing behavior: Correlation with cortical and subcortical binding of the dopamine D2 receptor antagonist [3H]-raclopride

European Neuropsychopharmacology ◽

10.1016/s0924-977x(02)80587-9 ◽

2002 ◽

Vol 12 ◽

pp. 365

Author(s):

M. Siemiatkowski ◽

A. Plaznik ◽

W. Kostowski

Keyword(s):

Receptor Antagonist ◽

Open Field ◽

Dopamine D2 Receptor ◽

D2 Receptor ◽

Freezing Behavior ◽

Dopamine D2 ◽

Dopamine D2 Receptor Antagonist

Download Full-text

Pharmacokinetics and central nervous system effects of the novel dopamine D2 receptor antagonist JNJ-37822681

Journal of Psychopharmacology ◽

10.1177/0269881111415733 ◽

2011 ◽

Vol 26 (8) ◽

pp. 1119-1127 ◽

Cited By ~ 9

Author(s):

Erik T te Beek ◽

Matthijs Moerland ◽

Peter de Boer ◽

Luc van Nueten ◽

Marieke L de Kam ◽

...

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Receptor Antagonist ◽

Dopamine D2 Receptor ◽

D2 Receptor ◽

The Novel ◽

Dopamine D2 ◽

Dopamine D2 Receptor Antagonist

Download Full-text

1079 NG101: A Potent and Selective Dopamine D2 Receptor Antagonist as a Potential Alternative to Metoclopramide and Domperidone for the Treatment of Gastroparesis

Gastroenterology ◽

10.1016/s0016-5085(16)30794-6 ◽

2016 ◽

Vol 150 (4) ◽

pp. S214 ◽

Cited By ~ 3

Author(s):

Cyril De Colle ◽

Marieke van der Hart ◽

Jiande Chen ◽

Arash Rassoulpour ◽

Pankaj J. Pasricha

Keyword(s):

Receptor Antagonist ◽

Dopamine D2 Receptor ◽

D2 Receptor ◽

Dopamine D2 ◽

Potential Alternative ◽

Selective Dopamine ◽

Dopamine D2 Receptor Antagonist

Download Full-text

Population Pharmacokinetics of JNJ-37822681, a Selective Fast-Dissociating Dopamine D2-Receptor Antagonist, in Healthy Subjects and Subjects with Schizophrenia and Dose Selection Based on Simulated D2-Receptor Occupancy

Clinical Pharmacokinetics ◽

10.1007/s40262-013-0084-3 ◽

2013 ◽

Vol 52 (11) ◽

pp. 1005-1015 ◽

Cited By ~ 3

Author(s):

Eef Hoeben ◽

Martine Neyens ◽

Erik Mannaert ◽

Mark Schmidt ◽

An Vermeulen

Keyword(s):

Receptor Antagonist ◽

Population Pharmacokinetics ◽

Healthy Subjects ◽

Dopamine D2 Receptor ◽

D2 Receptor ◽

Receptor Occupancy ◽

Dose Selection ◽

Dopamine D2 ◽

Dopamine D2 Receptor Antagonist

Download Full-text

Differential responses to JNJ-37822681, a specific and fast dissociating dopamine D2 receptor antagonist, in cynomolgus monkey and Sprague-Dawley rat general toxicology studies: clinical observations, prolactin levels, mammary histopathology findings and

Journal of Applied Toxicology ◽

10.1002/jat.2916 ◽

2013 ◽

Vol 34 (9) ◽

pp. 974-992 ◽

Cited By ~ 3

Author(s):

Eric J. de Waal ◽

Maria Desmidt ◽

Sven Korte ◽

Marc Niehoff ◽

Kevan Chase ◽

...

Keyword(s):

Receptor Antagonist ◽

Cynomolgus Monkey ◽

Dopamine D2 Receptor ◽

D2 Receptor ◽

Sprague Dawley ◽

Dopamine D2 ◽

Clinical Observations ◽

Sprague Dawley Rat ◽

Differential Responses ◽

Dopamine D2 Receptor Antagonist

Download Full-text

CORRECTION TO “COMPARISON OF PREDICTION METHODS FOR IN VIVO CLEARANCE OF (S,S)-3-[3-(METHYLSULFONYL)PHENYL]-1-PROPYLPIPERIDINE HYDROCHLORIDE, A DOPAMINE D2 RECEPTOR ANTAGONIST, IN HUMANS”

Drug Metabolism and Disposition ◽

10.1124/dmd.32.10.1199 ◽

2004 ◽

Vol 32 (10) ◽

pp. 1199-1199

Keyword(s):

Receptor Antagonist ◽

Dopamine D2 Receptor ◽

D2 Receptor ◽

Prediction Methods ◽

Dopamine D2 ◽

Dopamine D2 Receptor Antagonist

Download Full-text

Dopamine D2 receptor antagonist sulpiride enhances dexamethasone responses in the treatment of drug-resistant and metastatic breast cancer

Acta Pharmacologica Sinica ◽

10.1038/aps.2017.24 ◽

2017 ◽

Vol 38 (9) ◽

pp. 1282-1296 ◽

Cited By ~ 12

Author(s):

Jian Li ◽

Qing-yu Yao ◽

Jun-sheng Xue ◽

Li-jie Wang ◽

Yin Yuan ◽

...

Keyword(s):

Breast Cancer ◽

Metastatic Breast Cancer ◽

Receptor Antagonist ◽

Dopamine D2 Receptor ◽

D2 Receptor ◽

Metastatic Breast ◽

Drug Resistant ◽

Dopamine D2 ◽

Dopamine D2 Receptor Antagonist

Download Full-text

SLV313 (1-(2,3-Dihydro-Benzo[1,4]Dioxin-5-yl)-4- [5-(4-Fluoro-Phenyl)-Pyridin-3-ylmethyl]-Piperazine Monohydrochloride): A Novel Dopamine D2 Receptor Antagonist and 5-HT1A Receptor Agonist Potential Antipsychotic Drug

Neuropsychopharmacology ◽

10.1038/sj.npp.1301098 ◽

2006 ◽

Vol 32 (1) ◽

pp. 78-94 ◽

Cited By ~ 44

Author(s):

Andrew C McCreary ◽

Jeffrey C Glennon ◽

Charles R Ashby ◽

Herbert Y Meltzer ◽

Zhu Li ◽

...

Keyword(s):

Receptor Antagonist ◽

Antipsychotic Drug ◽

Receptor Agonist ◽

Dopamine D2 Receptor ◽

D2 Receptor ◽

Dopamine D2 ◽

Dopamine D2 Receptor Antagonist

Download Full-text

Enhancement of antipsychotic-like properties of the dopamine D2 receptor antagonist, raclopride, by the additional treatment with the 5-HT2 receptor blocking agent, ritanserin, in the rat

European Neuropsychopharmacology ◽

10.1016/s0924-977x(96)00035-1 ◽

1996 ◽

Vol 6 (4) ◽

pp. 305-310 ◽

Cited By ~ 28

Author(s):

M-L. Wadenberg ◽

Peter Salmi ◽

Patricia Jimenez ◽

Torgny Svensson ◽

Sven Ahlenius

Keyword(s):

Receptor Antagonist ◽

Dopamine D2 Receptor ◽

D2 Receptor ◽

Blocking Agent ◽

Additional Treatment ◽

Receptor Blocking ◽

Dopamine D2 ◽

Dopamine D2 Receptor Antagonist

Download Full-text