Self-Assembling Nano-Globular Peptide from Human Lactoferrin Acts as a Systemic Enhancer of Bone Regeneration: A Novel Peptide for Orthopedic Application

2021 ◽  
Author(s):  
Subhashis Pal ◽  
Mohd Sayeed ◽  
Amit Kumar ◽  
Devesh P. Verma ◽  
Munesh K. Harioudh ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Human Lactoferrin ◽  
Self Assembling

scholarly journals A biomimetic self-assembling peptide promotes bone regeneration in vivo: A rat cranial defect study

Bone ◽  
2019 ◽  
Vol 127 ◽  
pp. 602-611 ◽  
Author(s):  
Sushmita Saha ◽  
Xuebin B. Yang ◽  
Nagitha Wijayathunga ◽  
Sarah Harris ◽  
Georg A. Feichtinger ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Self Assembling ◽  
Cranial Defect

scholarly journals Design, characterization and evaluation of β-hairpin peptide hydrogels as a support for osteoblast cell growth and bovine lactoferrin delivery

RSC Advances ◽  
2020 ◽  
Vol 10 (31) ◽  
pp. 18222-18230
Author(s):  
Luis M. De Leon-Rodriguez ◽  
Young-Eun Park ◽  
Dorit Naot ◽  
David S. Musson ◽  
Jillian Cornish ◽  
...  
Keyword(s):  
Cell Growth ◽  
Bone Regeneration ◽  
Cell Number ◽  
Bovine Lactoferrin ◽  
Osteoblast Cell ◽  
Self Assembling ◽  
Peptide Hydrogels

Self-assembling peptide H4LMAX-RGDS hydrogels, designed to enhance bone regeneration, are cytocompatible and capable of delivering the bone anabolic factor lactoferrin to increase osteoblast cell number.

scholarly journals Functionalized D-form self-assembling peptide hydrogels for bone regeneration

2016 ◽  
pp. 1379 ◽  
Author(s):  
Bin He ◽  
Yunsheng Ou ◽  
Ao Zhou ◽  
Yong Zhu ◽  
Shuo Chen ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Self Assembling ◽  
Peptide Hydrogels

Self-assembling Peptides: From Bio-inspired Materials to Bone Regeneration

2008 ◽  
Vol 87 (7) ◽  
pp. 606-616 ◽  
Author(s):  
C. E. Semino
Keyword(s):  
Bone Regeneration ◽  
Nerve Repair ◽  
Three Dimensional ◽  
3D Culture ◽  
Functional Differentiation ◽  
Therapeutic Drug ◽  
Functional Requirements ◽  
Self Assembling

In recent years, the development of new biomaterials with specifications for tissue and organ functional requirements—such as proper biological, structural, and biomechanical properties as well as designed control for biodegradation and therapeutic drug-release capacity—is the main aim of many academic and industrial programs. Hence, the concept of molecular self-assembly is the driving force for the development of new biomaterials that support the growth and functional differentiation of cells and tissues in a controlled manner. The discovery, properties, and development of self-assembling peptides to be used as three-dimensional (3D) scaffolds based on their similarity (in structure and mechanical features) to extracellular matrices are described. Self-assembling peptides can be used for in vitro applications for cell 3D culture as well as in vivo for tissue regeneration such as bone and optical nerve repair, as well as for drug delivery of mediators to improve therapy, as in the case of myocardial infarction. Finally, the use of self-assembling materials in combination with a bioengineering platform is proposed to assist functional bone regeneration in cases of larger bone defects, including exposed fractures due to trauma and spinal disorders dealing with high loadings, as well as replacement of big bone structures due to tumors.

Self-Assembling Peptide Nanofiber Scaffolds, Platelet-Rich Plasma, and Mesenchymal Stem Cells for Injectable Bone Regeneration With Tissue Engineering

2009 ◽  
Vol 20 (5) ◽  
pp. 1523-1530 ◽  
Author(s):  
Ryoko Yoshimi ◽  
Yoichi Yamada ◽  
Kenji Ito ◽  
Sayaka Nakamura ◽  
Akihiro Abe ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Regeneration ◽  
Platelet Rich Plasma ◽  
Self Assembling ◽  
Nanofiber Scaffolds

Effects of a novel self‐assembling peptide scaffold on bone regeneration and controlled release of two growth factors

2021 ◽  
Author(s):  
Hongchuan Tian ◽  
Ai Guo ◽  
Kai Li ◽  
Bailong Tao ◽  
Dengliang Lei ◽  
...  
Keyword(s):  
Growth Factors ◽  
Controlled Release ◽  
Bone Regeneration ◽  
Self Assembling

Efficacy of a Self-Assembling Peptide Hydrogel, SPG-178-Gel, for Bone Regeneration and Three-Dimensional Osteogenic Induction of Dental Pulp Stem Cells

2017 ◽  
Vol 23 (23-24) ◽  
pp. 1394-1402 ◽  
Author(s):  
Jun Tsukamoto ◽  
Keiko Naruse ◽  
Yusuke Nagai ◽  
Shuhei Kan ◽  
Nobuhisa Nakamura ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Regeneration ◽  
Dental Pulp ◽  
Three Dimensional ◽  
Dental Pulp Stem Cells ◽  
Self Assembling ◽  
Osteogenic Induction ◽  
Peptide Hydrogel

scholarly journals Transplantation of human-induced pluripotent stem cells carried by self-assembling peptide nanofiber hydrogel improves bone regeneration in rat calvarial bone defects

BDJ Open ◽  
2016 ◽  
Vol 2 (1) ◽  
Author(s):  
Kamichika Hayashi ◽  
Hiromi Ochiai-Shino ◽  
Takeaki Shiga ◽  
Shoko Onodera ◽  
Akiko Saito ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Regeneration ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Bone Defects ◽  
Calvarial Bone ◽  
Self Assembling ◽  
Induced Pluripotent

Self-assembling peptide and nHA/CTS composite scaffolds promote bone regeneration through increasing seed cell adhesion

2018 ◽  
Vol 93 ◽  
pp. 445-454 ◽  
Author(s):  
Zhiming Zhang ◽  
Guofeng Wu ◽  
Yanlin Cao ◽  
Chun Liu ◽  
Yanglei Jin ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Bone Regeneration ◽  
Composite Scaffolds ◽  
Self Assembling ◽  
Seed Cell
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