Structure–Antibacterial Activity Relationships of Imidazolium-Type Ionic Liquid Monomers, Poly(ionic liquids) and Poly(ionic liquid) Membranes: Effect of Alkyl Chain Length and Cations

2016 ◽  
Vol 8 (20) ◽  
pp. 12684-12692 ◽  
Author(s):  
Zhiqiang Zheng ◽  
Qiming Xu ◽  
Jiangna Guo ◽  
Jing Qin ◽  
Hailei Mao ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Ionic Liquid ◽  
Ionic Liquids ◽  
Chain Length ◽  
Alkyl Chain ◽  
Alkyl Chain Length ◽  
Liquid Membranes ◽  
Poly Ionic Liquid

Phosphonium-based poly(Ionic liquid) membranes: The effect of cation alkyl chain length on light gas separation properties and Ionic conductivity

2016 ◽  
Vol 498 ◽  
pp. 408-413 ◽  
Author(s):  
Matthew G. Cowan ◽  
Miyuki Masuda ◽  
William M. McDanel ◽  
Yuki Kohno ◽  
Douglas L. Gin ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Ionic Conductivity ◽  
Chain Length ◽  
Gas Separation ◽  
Alkyl Chain ◽  
Alkyl Chain Length ◽  
Liquid Membranes ◽  
Poly Ionic Liquid

The effect of alkyl chain length on the structure and thermodynamics of protic–aprotic ionic liquid mixtures: a molecular dynamics study

2018 ◽  
Vol 20 (15) ◽  
pp. 9938-9949 ◽  
Author(s):  
Borja Docampo-Álvarez ◽  
Víctor Gómez-González ◽  
Trinidad Méndez-Morales ◽  
Julio R. Rodríguez ◽  
Oscar Cabeza ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Ionic Liquid ◽  
Ionic Liquids ◽  
Chain Length ◽  
Alkyl Chain ◽  
Molecular Complexes ◽  
Liquid Mixtures ◽  
Alkyl Chain Length ◽  
Ideal Behavior

Mixtures of protic and aprotic ionic liquids exhibit non-ideal behavior with increasing alkyl chain length, caused by the formation of molecular complexes.

In silico and in vitro studies of Imidazolium ionic liquids as effective antibacterial agents against multidrug resistant Escherichia coli strains

2020 ◽  
Vol 16 ◽  
Author(s):  
Diana Hodyna ◽  
Vasyl Kovalishyn ◽  
Ivan Semenyuta ◽  
Volodymyr Blagodatny ◽  
Sergiy Rogalsky ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Antibacterial Activity ◽  
Ionic Liquids ◽  
Chain Length ◽  
Active Site ◽  
Alkyl Chain ◽  
Multidrug Resistant ◽  
Alkyl Chain Length ◽  
E Coli

Background: Escherichia coli especially its multiresistant strains as the common foodborne pathogens cause blood stream infections, nosocomial pneumonia, infections of the skin and soft tissues. Therefore, the search for new effective biologically active compounds has been rapidly increasing in recent few decades. In this paper, we describe Quantitative Structure-Activity Relationships (QSAR) studies, molecular docking and in vitro antibacterial activity evaluation of series imidazolium-based ionic liquids (ILs) against E. coli spp. Methods: 2D fragment-based, classification and regression QSAR models were created using machine learning methods and types of descriptors via the OCHEM server. Biological testing of series of synthesized imidazolium ILs with predicted activity was performed by disc diffusion method. The most typical structures of symmetric and asymmetric ILs with high anti-E.coli activity (1e, 1h) were docked into the active site of enoylacyl carrier protein reductase (ENR) in E. coli. Results: Symmetric imidazolium ILs with C8 alkyl chain length demonstrated the highest antibacterial activity in comparison to the high antibacterial potential of asymmetric ILs with C12 alkyl chain length against drug-sensitive and drug-resistant E. coli strains including hemolytic E. coli. It should be noted that symmetric ILs with C6 or C9 alkyl chain length have the slightly lower activity against certain E. coli strains. The key role in the binding of compounds (1e, 1h) in the E. coli ENR active site associated with the NAD molecule and the amino acid residue Tyr146. Conclusion: The highly active symmetric and asymmetric imidazolium ILs can be considered as promising drug-candidates effective against E. coli spp. pathogens including multidrug resistant strains.

Spectroscopic Study on Imidazolium-Based Ionic Liquids: Effect of Alkyl Chain Length and Anion

2012 ◽  
Vol 116 (11) ◽  
pp. 3512-3518 ◽  
Author(s):  
Enrico Binetti ◽  
Annamaria Panniello ◽  
Leonardo Triggiani ◽  
Raffaele Tommasi ◽  
Angela Agostiano ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Spectroscopic Study ◽  
Chain Length ◽  
Alkyl Chain ◽  
Alkyl Chain Length
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