In Situ Growth of Self-Assembled Protein–Polymer Nanovesicles for Enhanced Intracellular Protein Delivery

2017 ◽  
Vol 9 (3) ◽  
pp. 2023-2028 ◽  
Author(s):  
Xinyu Liu ◽  
Weiping Gao
Keyword(s):  
Protein Delivery ◽  
In Situ Growth ◽  
Intracellular Protein ◽  
Protein Polymer ◽  
Self Assembled ◽  
Intracellular Protein Delivery

Enzyme-mediated in situ formation of pH-sensitive nanogels for proteins delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (10) ◽  
pp. 8032-8042 ◽  
Author(s):  
Zhipeng Zeng ◽  
Yingqi She ◽  
Zhiping Peng ◽  
Junchao Wei ◽  
Xiaohui He
Keyword(s):  
Protein Delivery ◽  
Ph Sensitive ◽  
Crosslinking Reaction ◽  
Intracellular Protein ◽  
In Situ Formation ◽  
Intracellular Protein Delivery

pH-Sensitive (PEG-b-P(LGA-g-Tyr)) nanogels were fabricated through the enzyme-mediated crosslinking reaction and used to load FITC-BSA for intracellular protein delivery.

Self-Assembled Cationic Nanogels for Intracellular Protein Delivery

2008 ◽  
Vol 19 (4) ◽  
pp. 882-890 ◽  
Author(s):  
Hirohito Ayame ◽  
Nobuyuki Morimoto ◽  
Kazunari Akiyoshi
Keyword(s):  
Protein Delivery ◽  
Intracellular Protein ◽  
Self Assembled ◽  
Intracellular Protein Delivery

An intracellular protein delivery platform based on glutathione-responsive protein nanocapsules

2016 ◽  
Vol 52 (93) ◽  
pp. 13608-13611 ◽  
Author(s):  
Jie Li ◽  
Linlin Zhang ◽  
Yang Liu ◽  
Jing Wen ◽  
Di Wu ◽  
...  
Keyword(s):  
Protein Delivery ◽  
Intracellular Delivery ◽  
Intracellular Protein ◽  
Disulfide Crosslinking ◽  
Efficient Strategy ◽  
Protein Polymer ◽  
Delivery Platform ◽  
The Stability ◽  
Intracellular Protein Delivery ◽  
Polymer Assembly

We reported an efficient strategy for the intracellular delivery of proteins based on assembling proteins with a self-crosslinkable polymer. The disulfide-crosslinking structure enhances the stability of the protein–polymer assembly, and also allows effective dissociation of the assembly in response to glutathione.

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